| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 22.22% | 20.85% | #1 | $2.13B | 17.2M | $1.77B | 17.2M | 00.00% | Unchanged |
| Paradigm Biocapital Advisors LP |
| 13.7% | 11.15% | #3 | $731.7M | 5.9M | $545.5M | 5.3M | +600,000+11.27% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #126 | $689.8M | 5.6M | $494.3M | 4.8M | +760,834+15.77% | Add |
| HBK INVESTMENTS L P |
| 4.2% | — | #13 | $430.2M | 3.5M | $0 | 0 | +3.5M | New Buy |
| FIL Ltd |
| 0.26% | <0.01% | #48 | $363.9M | 2.9M | $6,659 | 65 | +2.9M+4,532,986.15% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #117 | $319.8M | 2.6M | $256.2M | 2.5M | +88,375+3.53% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #144 | $303.7M | 2.5M | $248.8M | 2.4M | +30,630+1.26% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #135 | $258.2M | 2.1M | $208.6M | 2.0M | +55,213+2.71% | Add |
| Deep Track Capital, LP |
| 3.21% | 2.3% | #14 | $220.2M | 1.8M | $141.0M | 1.4M | +406,998+29.57% | Add |
| GLAZER CAPITAL, LLC |
| 5.44% | — | #8 | $218.6M | 1.8M | $0 | 0 | +1.8M | New Buy |
| GOLDMAN SACHS GROUP INC |
| 0.02% | 0.01% | #105 | $202.6M | 1.6M | $55.0M | 537,158 | +1.1M+205.47% | Add |
| PERCEPTIVE ADVISORS LLC |
| 2.93% | 3.16% | #15 | $195.2M | 1.6M | $161.9M | 1.6M | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.23% | — | #50 | $181.6M | 1.5M | $0 | 0 | +1.5M | New Buy |
| FMR LLC |
| 0.01% | 0.05% | #136 | $175.1M | 1.4M | $950.2M | 9.3M | -7.9M-84.72% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #128 | $173.8M | 1.4M | $133.0M | 1.3M | +109,246+8.42% | Add |
| BARCLAYS PLC |
| 0.03% | <0.01% | #94 | $156.6M | 1.3M | $3.2M | 30,844 | +1.2M+4,011.87% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 1.34% | 2.75% | #22 | $153.9M | 1.2M | $259.6M | 2.5M | -1.3M-50.81% | Reduce |
| Pentwater Capital Management LP |
| 0.89% | — | #31 | $145.1M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Bellevue Group AG |
| 2.74% | 2.57% | #16 | $130.1M | 1.1M | $107.9M | 1.1M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #139 | $108.3M | 876,830 | $22.2M | 216,516 | +660,314+304.97% | Add |
| First Trust Capital Management L.P. |
| 5.97% | — | #7 | $103.4M | 836,918 | $0 | 0 | +836,918 | New Buy |
| MILLENNIUM MANAGEMENT LLC |
| 0.03% | <0.01% | #92 | $94.1M | 761,592 | $1.8M | 18,057 | +743,535+4,117.71% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #160 | $84.1M | 681,225 | $23.8M | 275,110 | +406,115+147.62% | Add |
| NEXPOINT ASSET MANAGEMENT, L.P. |
| 5.1% | — | #10 | $76.3M | 617,820 | $0 | 0 | +617,820 | New Buy |
| AQR Arbitrage LLC |
| 1.06% | — | #28 | $74.3M | 601,633 | $0 | 0 | +601,633 | New Buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.24% | — | #49 | $72.3M | 585,583 | $0 | 0 | +585,583 | New Buy |
| NORGES BANK |
| 0.01% | <0.01% | #140 | $69.2M | 560,041 | $9.3M | 131,618 | +428,423+325.50% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #137 | $62.8M | 508,124 | $44.0M | 429,373 | +78,751+18.34% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #134 | $58.1M | 470,221 | $46.2M | 450,801 | +19,420+4.31% | Add |
| Verition Fund Management LLC |
| 0.06% | — | #76 | $48.2M | 390,521 | $0 | 0 | +390,521 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #124 | $47.2M | 382,382 | $37.3M | 364,167 | +18,215+5.00% | Add |
| ExodusPoint Capital Management, LP |
| 0.29% | — | #45 | $45.1M | 364,712 | $0 | 0 | +364,712 | New Buy |
| Allianz Asset Management GmbH |
| 0.04% | <0.01% | #86 | $44.2M | 359,200 | $686,415 | 6,700 | +352,500+5,261.19% | Add |
| Absolute Gestao de Investimentos Ltda. |
| 4.35% | — | #12 | $43.2M | 350,000 | $0 | 0 | +350,000 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | 0.02% | #187 | $40.8M | 327,692 | $298.7M | 3.1M | -2.8M-89.39% | Reduce |
| Polar Asset Management Partners Inc. |
| 0.65% | — | #34 | $39.6M | 320,529 | $0 | 0 | +320,529 | New Buy |
| SOROS FUND MANAGEMENT LLC |
| 0.45% | — | #37 | $37.1M | 300,017 | $0 | 0 | +300,017 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #180 | $36.0M | 291,317 | $3.8M | 36,753 | +254,564+692.63% | Add |
| Kryger Capital LLC |
| 2.02% | — | #19 | $35.4M | 286,712 | $0 | 0 | +286,712 | New Buy |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.05% | 0.01% | #81 | $34.7M | 280,900 | $9.1M | 89,000 | +191,900+215.62% | Add |
| WHITEBOX ADVISORS LLC |
| 0.44% | — | #38 | $34.0M | 275,001 | $0 | 0 | +275,001 | New Buy |
| Affinity Asset Advisors, LLC |
| 1.54% | 1.59% | #21 | $34.0M | 275,000 | $30.7M | 300,000 | -25,000-8.33% | Reduce |
| Cinctive Capital Management LP |
| 1.09% | — | #26 | $29.7M | 240,806 | $0 | 0 | +240,806 | New Buy |
| ODDO BHF ASSET MANAGEMENT SAS |
| 1.31% | — | #24 | $28.1M | 227,386 | $0 | 0 | +227,386 | New Buy |
| OMERS ADMINISTRATION Corp |
| 0.17% | — | #53 | $27.8M | 225,500 | $0 | 0 | +225,500 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | 0.05% | #158 | $26.8M | 217,213 | $253.1M | 2.5M | -2.3M-91.21% | Reduce |
| Slotnik Capital, LLC |
| 6.7% | — | #5 | $25.9M | 210,000 | $0 | 0 | +210,000 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.01% | #103 | $25.8M | 208,978 | $10.5M | 102,118 | +106,860+104.64% | Add |
| TUDOR INVESTMENT CORP ET AL |
| 0.04% | <0.01% | #88 | $25.4M | 206,068 | $425,168 | 4,150 | +201,918+4,865.49% | Add |
| Sagefield Capital LP |
| 1.8% | — | #20 | $24.3M | 196,481 | $0 | 0 | +196,481 | New Buy |
