| GREAT POINT PARTNERS LLC |
| 0.73% | 1.59% | #3 | $3.8M | 944,292 | $6.9M | 7.6M | -6.6M-87.50% | Reduce |
| Squadron Capital Management LLC |
| 0.96% | 2.56% | #2 | $3.1M | 756,884 | $7.0M | 7.6M | -6.9M-90.05% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #13 | $2.2M | 543,478 | $0 | 0 | +543,478 | New Buy |
| Propel Bio Management, LLC |
| 1.16% | — | #1 | $2.2M | 543,478 | $0 | 0 | +543,478 | New Buy |
| Woodline Partners LP |
| <0.01% | — | #12 | $1.6M | 387,520 | $0 | 0 | +387,520 | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $1.2M | 296,747 | $1.4M | 1.6M | -1.3M-81.03% | Reduce |
| Avidity Partners Management LP |
| 0.17% | 0.39% | #5 | $1.1M | 260,206 | $1.9M | 2.1M | -1.8M-87.50% | Reduce |
| KINGDON CAPITAL MANAGEMENT, L.L.C. |
| 0.1% | 0.2% | #8 | $1.0M | 247,811 | $1.8M | 2.0M | -1.7M-87.50% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $735,807 | 180,788 | $570,459 | 622,161 | -441,373-70.94% | Reduce |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 0.14% | 0.53% | #6 | $612,743 | 150,551 | $1.9M | 2.1M | -1.9M-92.79% | Reduce |
| DAFNA Capital Management LLC |
| 0.11% | 0.23% | #7 | $552,983 | 135,868 | $996,630 | 1.1M | -951,088-87.50% | Reduce |
| Empery Asset Management, LP |
| 0.6% | 2.04% | #4 | $514,656 | 126,451 | $1.7M | 1.8M | -1.7M-93.16% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #16 | $474,843 | 116,669 | $670,000 | 731,952 | -615,283-84.06% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #25 | $334,169 | 82,093 | $446,036 | 486,368 | -404,275-83.12% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #17 | $311,457 | 76,525 | $205,972 | 224,640 | -148,115-65.93% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #22 | $235,938 | 57,970 | $207,000 | 225,736 | -167,766-74.32% | Reduce |
| ADAR1 Capital Management, LLC |
| 0.01% | — | #11 | $201,005 | 49,387 | $0 | 0 | +49,387 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #30 | $168,995 | 41,522 | $304,589 | 332,194 | -290,672-87.50% | Reduce |
| Velan Capital Investment Management LP |
| 0.1% | — | #9 | $162,800 | 40,000 | $0 | 0 | +40,000 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #26 | $91,107 | 22,385 | $87,635 | 95,577 | -73,192-76.58% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #14 | $63,305 | 15,554 | $114,096 | 124,437 | -108,883-87.50% | Reduce |
| Empowered Funds, LLC |
| <0.01% | <0.01% | #18 | $62,931 | 15,462 | $113,418 | 123,697 | -108,235-87.50% | Reduce |
| WEALTH EFFECTS LLC |
| 0.02% | 0.03% | #10 | $56,467 | 13,874 | $80,229 | 87,500 | -73,626-84.14% | Reduce |
| XTX Topco Ltd |
| <0.01% | <0.01% | #15 | $52,743 | 12,959 | $47,939 | 52,284 | -39,325-75.21% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #28 | $45,678 | 11,223 | $4 | 4 | +11,219+280,475.00% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #27 | $40,781 | 10,020 | $0 | 0 | +10,020 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #34 | $16,658 | 4,093 | $12,089 | 15,700 | -11,607-73.93% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #31 | $3,810 | 936 | $6,866 | 7,488 | -6,552-87.50% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #21 | $2,646 | 650 | $0 | 0 | +650 | New Buy |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #37 | $2,000 | 602 | $1,000 | 820 | -218-26.59% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #33 | $1,591 | 391 | $3,667 | 4,000 | -3,609-90.23% | Reduce |
| US BANCORP \DE\ |
| <0.01% | <0.01% | #32 | $1,575 | 387 | $2,843 | 3,100 | -2,713-87.52% | Reduce |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | <0.01% | #36 | $1,262 | 310 | $2,280 | 2,487 | -2,177-87.54% | Reduce |
| BARCLAYS PLC |
| <0.01% | — | #38 | $1,184 | 291 | $0 | 0 | +291 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #35 | $679 | 167 | $1,586 | 1,730 | -1,563-90.35% | Reduce |
| HighMark Wealth Management LLC |
| <0.01% | <0.01% | #20 | $537 | 132 | $977 | 1,066 | -934-87.62% | Reduce |
| Cornerstone Planning Group LLC |
| <0.01% | — | #24 | $146 | 37 | $0 | 0 | +37 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #29 | $118 | 29 | $213 | 232 | -203-87.50% | Reduce |
| Bogart Wealth, LLC |
| <0.01% | — | #39 | $4 | 1 | $0 | 0 | +1 | New Buy |
