| FMR LLC |
| 0.03% | 0.03% | #81 | $704.6M | 7.6M | $507.4M | 5.7M | +1.9M+32.62% | Add |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.21% | 0.27% | #31 | $351.0M | 3.8M | $337.2M | 3.8M | -21,680-0.57% | Reduce |
| DODGE & COX |
| 0.18% | 0.18% | #35 | $342.2M | 3.7M | $326.8M | 3.7M | +800+0.02% | Add |
| FLOSSBACH VON STORCH SE |
| 0.94% | 1.53% | #12 | $207.1M | 2.2M | $327.1M | 3.7M | -1.5M-39.51% | Reduce |
| T. Rowe Price Investment Management, Inc. |
| 0.13% | 0.36% | #39 | $192.2M | 2.1M | $520.5M | 5.9M | -3.8M-64.73% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #166 | $172.6M | 1.9M | $147.4M | 1.7M | +196,813+11.87% | Add |
| Temasek Holdings (Private) Ltd |
| 0.38% | 0.44% | #21 | $140.1M | 1.5M | $133.9M | 1.5M | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.06% | 0.07% | #60 | $122.8M | 1.3M | $148.3M | 1.7M | -332,442-20.12% | Reduce |
| Logos Global Management LP |
| 4.07% | — | #3 | $94.4M | 1.0M | $0 | 0 | +1.0M | New Buy |
| CITADEL ADVISORS LLC |
| 0.01% | 0.02% | #122 | $87.4M | 939,195 | $136.9M | 1.5M | -601,487-39.04% | Reduce |
| GSK plc |
| 13.75% | 13.2% | #1 | $82.8M | 889,824 | $79.1M | 889,824 | 00.00% | Unchanged |
| Squarepoint Ops LLC |
| 0.08% | 0.01% | #50 | $76.2M | 819,304 | $10.9M | 122,949 | +696,355+566.38% | Add |
| FIRST TRUST ADVISORS LP |
| 0.04% | 0.05% | #70 | $73.6M | 791,469 | $74.7M | 839,991 | -48,522-5.78% | Reduce |
| Davern Capital Partners, LP |
| 11.97% | 7.44% | #2 | $70.2M | 754,550 | $27.1M | 305,055 | +449,495+147.35% | Add |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| 0.01% | 0.01% | #114 | $69.2M | 744,200 | $69.7M | 783,995 | -39,795-5.08% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.02% | 0.02% | #92 | $63.1M | 677,708 | $59.6M | 670,514 | +7,194+1.07% | Add |
| Long Focus Capital Management, LLC |
| 1.49% | 1.46% | #9 | $58.1M | 624,000 | $55.5M | 624,000 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | 0.01% | #147 | $57.1M | 613,716 | $67.9M | 763,661 | -149,945-19.64% | Reduce |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #143 | $56.1M | 602,403 | $8.6M | 96,829 | +505,574+522.13% | Add |
| BAILLIE GIFFORD & CO |
| 0.05% | 0.08% | #65 | $55.1M | 592,380 | $78.4M | 882,572 | -290,192-32.88% | Reduce |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.03% | 0.03% | #83 | $50.2M | 539,787 | $42.4M | 476,923 | +62,864+13.18% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #120 | $50.2M | 539,593 | $34.2M | 384,626 | +154,967+40.29% | Add |
| Candriam S.C.A. |
| 0.21% | 0.29% | #30 | $46.3M | 497,530 | $57.6M | 604,916 | -107,386-17.75% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #168 | $45.8M | 492,092 | $59.5M | 603,016 | -110,924-18.39% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #162 | $45.2M | 486,205 | $80.3M | 903,029 | -416,824-46.16% | Reduce |
| CITIGROUP INC |
| 0.01% | 0.02% | #106 | $45.1M | 484,784 | $36.5M | 410,166 | +74,618+18.19% | Add |
| D. E. Shaw & Co., Inc. |
| 0.02% | 0.01% | #90 | $44.9M | 482,421 | $23.5M | 264,768 | +217,653+82.21% | Add |
| DekaBank Deutsche Girozentrale |
| 0.07% | 0.07% | #55 | $44.8M | 481,397 | $42.1M | 481,397 | 00.00% | Unchanged |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.06% | 0.01% | #63 | $44.7M | 480,763 | $10.6M | 119,155 | +361,608+303.48% | Add |
| TANG CAPITAL MANAGEMENT LLC |
| 1.99% | 2.12% | #6 | $43.7M | 470,000 | $41.8M | 470,000 | 00.00% | Unchanged |
| Assenagon Asset Management S.A. |
| 0.05% | — | #66 | $39.4M | 423,263 | $0 | 0 | +423,263 | New Buy |
| LBP AM SA |
| 0.36% | 0.47% | #22 | $36.1M | 388,498 | $34.2M | 385,109 | +3,389+0.88% | Add |
| MARSHALL WACE, LLP |
| 0.03% | 0.02% | #84 | $35.6M | 382,147 | $22.5M | 254,446 | +127,701+50.19% | Add |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main |
| 0.03% | 0.03% | #86 | $35.3M | 379,081 | $34.4M | 387,214 | -8,133-2.10% | Reduce |
| DEUTSCHE BANK AG\ |
| 0.01% | 0.01% | #121 | $35.1M | 377,432 | $34.8M | 391,689 | -14,257-3.64% | Reduce |
| SG Americas Securities, LLC |
| 0.02% | 0.03% | #100 | $32.3M | 347,131 | $24.0M | 270,245 | +76,886+28.45% | Add |
| Point72 Asset Management, L.P. |
| 0.03% | — | #79 | $30.4M | 327,184 | $0 | 0 | +327,184 | New Buy |
| Legal & General Group Plc |
| 0.01% | 0.01% | #135 | $29.8M | 320,287 | $31.0M | 350,008 | -29,721-8.49% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| 0.02% | 0.01% | #93 | $27.4M | 294,814 | $14.8M | 166,179 | +128,635+77.41% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | 0.01% | #171 | $26.8M | 288,090 | $56.9M | 640,357 | -352,267-55.01% | Reduce |
| CANADA PENSION PLAN INVESTMENT BOARD |
| 0.01% | 0.02% | #108 | $25.8M | 276,860 | $27.0M | 303,508 | -26,648-8.78% | Reduce |
| Walleye Trading LLC |
| 0.03% | 0.04% | #82 | $25.6M | 274,590 | $23.3M | 262,131 | +12,459+4.75% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #159 | $25.2M | 271,251 | $22.6M | 254,328 | +16,923+6.65% | Add |
| Hudson Bay Capital Management LP |
| 0.07% | 0.08% | #56 | $24.2M | 260,000 | $24.4M | 275,000 | -15,000-5.45% | Reduce |
| CenterBook Partners LP |
| 1.15% | 0.82% | #11 | $23.4M | 251,083 | $15.2M | 171,166 | +79,917+46.69% | Add |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.03% | 0.04% | #78 | $23.2M | 249,399 | $23.1M | 259,733 | -10,334-3.98% | Reduce |
| SEB Asset Management AB |
| 0.09% | 0.08% | #49 | $22.8M | 245,068 | $17.8M | 200,108 | +44,960+22.47% | Add |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC |
| 0.1% | 0.11% | #46 | $22.7M | 243,422 | $27.4M | 307,864 | -64,442-20.93% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #165 | $19.7M | 211,762 | $20.8M | 234,439 | -22,677-9.67% | Reduce |
| Pictet Asset Management Holding SA |
| 0.02% | 0.01% | #98 | $17.5M | 185,803 | $11.2M | 131,798 | +54,005+40.98% | Add |