| Frazier Life Sciences Management, L.P. |
| 19.58% | 18.25% | #1 | $899.1M | 7.7M | $709.4M | 7.7M | 00.00% | Unchanged |
| Jupiter Topco LLC |
| 0.28% | — | #48 | $691.7M | 5.9M | $0 | 0 | +5.9M | New Buy |
| BlackRock, Inc. |
| 0.01% | 0.01% | #162 | $513.9M | 4.4M | $355.3M | 3.8M | +543,533+14.13% | Add |
| FMR LLC |
| 0.02% | 0.01% | #128 | $429.7M | 3.7M | $181.6M | 2.0M | +1.7M+86.75% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #115 | $310.9M | 2.7M | $158.7M | 1.7M | +938,186+54.63% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | 0.01% | #141 | $278.3M | 2.4M | $132.3M | 1.4M | +944,936+65.98% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #182 | $263.9M | 2.3M | $223.1M | 2.4M | -160,667-6.65% | Reduce |
| STATE STREET CORP |
| 0.01% | 0.01% | #163 | $254.1M | 2.2M | $179.6M | 1.9M | +226,408+11.64% | Add |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.49% | 0.1% | #36 | $164.5M | 1.4M | $31.0M | 335,669 | +1.1M+318.49% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #156 | $163.2M | 1.4M | $116.4M | 1.3M | +133,905+10.63% | Add |
| Invesco Ltd. |
| 0.01% | <0.01% | #140 | $159.7M | 1.4M | $26.4M | 285,236 | +1.1M+378.23% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #119 | $153.4M | 1.3M | $123.3M | 1.3M | -24,822-1.86% | Reduce |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 1.95% | 2.15% | #18 | $146.2M | 1.2M | $130.1M | 1.4M | -160,482-11.39% | Reduce |
| TANG CAPITAL MANAGEMENT LLC |
| 6.57% | 5.8% | #4 | $144.7M | 1.2M | $114.2M | 1.2M | 00.00% | Unchanged |
| Capital World Investors |
| 0.02% | 0.01% | #131 | $135.0M | 1.2M | $66.9M | 724,415 | +429,065+59.23% | Add |
| FRANKLIN RESOURCES INC |
| 0.03% | 0.01% | #118 | $135.0M | 1.2M | $66.0M | 714,804 | +437,966+61.27% | Add |
| Novo Holdings A/S |
| 7.67% | 9.92% | #3 | $131.7M | 1.1M | $122.4M | 1.3M | -200,000-15.09% | Reduce |
| TCG Crossover Management, LLC |
| 2.99% | 2.81% | #12 | $124.3M | 1.1M | $98.1M | 1.1M | 00.00% | Unchanged |
| BVF INC/IL |
| 3.16% | 4.66% | #11 | $123.6M | 1.1M | $146.4M | 1.6M | -528,700-33.36% | Reduce |
| Polar Capital Holdings Plc |
| 0.23% | 0.09% | #55 | $99.0M | 845,524 | $26.2M | 283,484 | +562,040+198.26% | Add |
| Rock Springs Capital Management LP |
| 4.56% | 4.42% | #7 | $93.4M | 798,145 | $74.9M | 811,294 | -13,149-1.62% | Reduce |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.13% | 0.06% | #76 | $88.0M | 752,044 | $37.4M | 405,321 | +346,723+85.54% | Add |
| AMERIPRISE FINANCIAL INC |
| 0.02% | <0.01% | #130 | $85.1M | 726,694 | $20.3M | 219,255 | +507,439+231.44% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.06% | 0.06% | #97 | $80.8M | 690,318 | $71.6M | 774,841 | -84,523-10.91% | Reduce |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #139 | $78.4M | 669,974 | $54.0M | 584,523 | +85,451+14.62% | Add |
| Clearbridge Investments, LLC |
| 0.06% | 0.05% | #94 | $74.9M | 639,734 | $62.1M | 671,870 | -32,136-4.78% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.04% | #112 | $71.0M | 606,427 | $84.2M | 911,419 | -304,992-33.46% | Reduce |
| Woodline Partners LP |
| 0.21% | 0.2% | #57 | $66.5M | 567,894 | $52.5M | 567,894 | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #196 | $65.8M | 561,724 | $66.7M | 722,177 | -160,453-22.22% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #184 | $64.4M | 549,874 | $61.2M | 662,306 | -112,432-16.98% | Reduce |
| LORD, ABBETT & CO. LLC |
| 0.18% | 0.19% | #62 | $63.3M | 540,977 | $57.0M | 617,064 | -76,087-12.33% | Reduce |
| Pictet Asset Management Holding SA |
| 0.06% | 0.04% | #96 | $61.6M | 526,443 | $39.1M | 423,511 | +102,932+24.30% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.07% | 0.06% | #87 | $57.3M | 489,170 | $49.8M | 539,031 | -49,861-9.25% | Reduce |
| EMERALD ADVISERS, LLC |
| 1.29% | 1.16% | #23 | $54.8M | 468,295 | $36.7M | 397,263 | +71,032+17.88% | Add |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #177 | $52.9M | 452,036 | $36.5M | 394,920 | +57,116+14.46% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #168 | $52.6M | 449,429 | $39.5M | 427,090 | +22,339+5.23% | Add |
| BAKER BROS. ADVISORS LP |
| 0.26% | 0.24% | #49 | $52.2M | 445,975 | $41.2M | 445,975 | 00.00% | Unchanged |
| LOOMIS SAYLES & CO L P |
| 0.07% | 0.06% | #93 | $51.9M | 443,636 | $43.9M | 475,324 | -31,688-6.67% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.07% | 0.08% | #88 | $51.8M | 442,185 | $53.8M | 582,085 | -139,900-24.03% | Reduce |
| FEDERATED HERMES, INC. |
| 0.07% | 0.08% | #86 | $51.1M | 436,635 | $46.8M | 506,211 | -69,576-13.74% | Reduce |
| NEXT CENTURY GROWTH INVESTORS LLC |
| 2.61% | 2.63% | #15 | $49.2M | 420,213 | $35.6M | 385,539 | +34,674+8.99% | Add |
| Connor, Clark & Lunn Investment Management Ltd. |
| 0.09% | 0.1% | #84 | $49.2M | 420,063 | $44.3M | 479,476 | -59,413-12.39% | Reduce |
| BOONE CAPITAL MANAGEMENT LLC |
| 11.38% | 11.92% | #2 | $48.7M | 415,641 | $38.9M | 421,236 | -5,595-1.33% | Reduce |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | 0.01% | #133 | $45.0M | 384,570 | $26.5M | 286,406 | +98,164+34.27% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #181 | $44.5M | 379,760 | $45.7M | 494,994 | -115,234-23.28% | Reduce |
| Candriam S.C.A. |
| 0.2% | 0.23% | #59 | $44.0M | 376,143 | $45.0M | 569,590 | -193,447-33.96% | Reduce |
| TimesSquare Capital Management, LLC |
| 0.63% | 0.59% | #31 | $43.0M | 367,281 | $34.8M | 376,473 | -9,192-2.44% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #223 | $41.1M | 351,404 | $49.1M | 670,149 | -318,745-47.56% | Reduce |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.06% | 0.05% | #99 | $41.0M | 350,000 | $34.6M | 375,000 | -25,000-6.67% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #154 | $40.8M | 348,230 | $30.8M | 333,327 | +14,903+4.47% | Add |
