| FMR LLC |
| 0.03% | 0.03% | #113 | $582.4M | 9.6M | $629.1M | 10.8M | -1.2M-10.82% | Reduce |
| BlackRock, Inc. |
| 0.01% | 0.01% | #148 | $454.1M | 7.5M | $328.0M | 5.6M | +1.9M+33.37% | Add |
| Avoro Capital Advisors LLC |
| 3.13% | 3.31% | #8 | $348.7M | 5.8M | $336.0M | 5.8M | 00.00% | Unchanged |
| Polar Capital Holdings Plc |
| 0.65% | 0.91% | #31 | $275.9M | 4.6M | $256.2M | 4.4M | +165,244+3.75% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.55% | 1.92% | #19 | $266.7M | 4.4M | $261.2M | 4.5M | -73,096-1.63% | Reduce |
| Jupiter Topco LLC |
| 0.1% | — | #70 | $252.7M | 4.2M | $0 | 0 | +4.2M | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #119 | $196.1M | 3.2M | $77.3M | 1.3M | +1.9M+144.30% | Add |
| JPMORGAN CHASE & CO |
| 0.01% | 0.01% | #141 | $157.4M | 2.6M | $106.9M | 1.9M | +693,750+36.07% | Add |
| Capital International Investors |
| 0.03% | 0.04% | #106 | $142.5M | 2.4M | $155.5M | 2.7M | -313,088-11.71% | Reduce |
| T. Rowe Price Investment Management, Inc. |
| 0.09% | 0.04% | #78 | $130.9M | 2.2M | $55.4M | 951,955 | +1.2M+127.80% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #190 | $118.9M | 2.0M | $100.0M | 1.7M | +249,096+14.48% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.07% | 0.03% | #83 | $99.2M | 1.6M | $35.2M | 606,085 | +1.0M+171.06% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 1.02% | 1.11% | #24 | $97.5M | 1.6M | $94.0M | 1.6M | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 4.35% | 5.03% | #4 | $96.3M | 1.6M | $97.4M | 1.7M | -80,000-4.78% | Reduce |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.3% | 0.34% | #44 | $91.0M | 1.5M | $81.5M | 1.4M | +105,811+7.55% | Add |
| ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #103 | $90.8M | 1.6M | $62.9M | 1.4M | +158,979+11.33% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.03% | #137 | $87.4M | 1.4M | $167.8M | 2.9M | -1.4M-49.83% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #121 | $86.8M | 1.4M | $74.5M | 1.3M | +157,135+12.27% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.05% | #129 | $86.0M | 1.4M | $280.8M | 4.8M | -3.4M-70.48% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #172 | $82.7M | 1.4M | $63.5M | 1.1M | +277,182+25.36% | Add |
| Siren, L.L.C. |
| 1.61% | 2.13% | #18 | $79.6M | 1.3M | $76.7M | 1.3M | 00.00% | Unchanged |
| BNP Paribas Asset Management Holding S.A. |
| 0.08% | — | #80 | $77.9M | 1.3M | $0 | 0 | +1.3M | New Buy |
| Pictet Asset Management Holding SA |
| 0.07% | 0.04% | #84 | $71.6M | 1.2M | $39.2M | 679,709 | +508,014+74.74% | Add |
| BRAIDWELL LP |
| 2.53% | 2.6% | #12 | $68.3M | 1.1M | $77.8M | 1.3M | -207,000-15.47% | Reduce |
| Nuveen, LLC |
| 0.01% | <0.01% | #132 | $59.9M | 993,126 | $14.5M | 250,036 | +743,090+297.19% | Add |
| Invesco Ltd. |
| <0.01% | <0.01% | #175 | $54.5M | 903,458 | $3.4M | 59,103 | +844,355+1,428.62% | Add |
| ORBIMED ADVISORS LLC |
| 1.02% | 1.22% | #25 | $53.9M | 892,471 | $61.6M | 1.1M | -167,500-15.80% | Reduce |
| Caligan Partners LP |
| 2.53% | 5.39% | #11 | $53.7M | 889,944 | $81.0M | 1.4M | -503,083-36.11% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.02% | #115 | $53.4M | 884,319 | $39.5M | 679,314 | +205,005+30.18% | Add |
| FEDERATED HERMES, INC. |
| 0.08% | 0.09% | #81 | $53.3M | 883,737 | $56.5M | 972,237 | -88,500-9.10% | Reduce |
| Capital World Investors |
| 0.01% | 0.01% | #155 | $52.1M | 862,775 | $48.9M | 840,072 | +22,703+2.70% | Add |
| GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #178 | $46.7M | 773,625 | $44.8M | 769,875 | +3,750+0.49% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #207 | $45.2M | 749,651 | $31.6M | 543,062 | +206,589+38.04% | Add |
| Caption Management, LLC |
| 0.2% | 0.45% | #51 | $43.9M | 728,000 | $77.8M | 1.3M | -609,900-45.59% | Reduce |
| Vestal Point Capital, LP |
| 0.99% | 1.04% | #26 | $42.3M | 700,000 | $37.2M | 639,900 | +60,100+9.39% | Add |
| Alyeska Investment Group, L.P. |
| 0.11% | 0.21% | #68 | $42.1M | 697,692 | $75.6M | 1.3M | -601,777-46.31% | Reduce |
| MARSHALL WACE, LLP |
| 0.03% | — | #101 | $41.6M | 689,342 | $0 | 0 | +689,342 | New Buy |
| Rock Springs Capital Management LP |
| 2.01% | 2.62% | #15 | $41.3M | 683,907 | $44.4M | 763,020 | -79,113-10.37% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #168 | $40.5M | 671,566 | $30.7M | 527,783 | +143,783+27.24% | Add |
| PANAGORA ASSET MANAGEMENT INC |
| 0.12% | — | #66 | $40.1M | 664,031 | $0 | 0 | +664,031 | New Buy |
| First Turn Management, LLC |
| 3.88% | 5.11% | #6 | $36.2M | 600,200 | $45.8M | 786,844 | -186,644-23.72% | Reduce |
| TUDOR INVESTMENT CORP ET AL |
| 0.05% | 0.06% | #93 | $32.9M | 545,387 | $31.6M | 542,991 | +2,396+0.44% | Add |
| LOOMIS SAYLES & CO L P |
| 0.04% | 0.04% | #95 | $31.8M | 527,273 | $32.8M | 564,897 | -37,624-6.66% | Reduce |
| Octagon Capital Advisors LP |
| 2.66% | 3.15% | #10 | $29.6M | 490,000 | $28.5M | 490,000 | 00.00% | Unchanged |
| Novo Holdings A/S |
| 1.71% | 2.29% | #17 | $29.3M | 485,438 | $28.2M | 485,438 | 00.00% | Unchanged |
| Candriam S.C.A. |
| 0.13% | 0.09% | #65 | $27.9M | 462,768 | $18.7M | 417,402 | +45,366+10.87% | Add |
| TimesSquare Capital Management, LLC |
| 0.4% | 0.35% | #40 | $27.3M | 451,593 | $20.9M | 359,293 | +92,300+25.69% | Add |
| Logos Global Management LP |
| 1.17% | 1.31% | #23 | $27.2M | 450,000 | $26.2M | 450,000 | 00.00% | Unchanged |
| Trails Edge Capital Partners, LP |
| 4.22% | 8.53% | #5 | $26.6M | 440,000 | $37.2M | 640,000 | -200,000-31.25% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | <0.01% | #176 | $25.4M | 421,518 | $23.0M | 396,138 | +25,380+6.41% | Add |
