| Essex Woodlands Management, Inc. |
| 2.28% | 1.91% | #1 | $5.8M | 7.7M | $4.8M | 7.7M | 00.00% | Unchanged |
| Nantahala Capital Management, LLC |
| 0.15% | 0.13% | #6 | $4.4M | 5.9M | $3.7M | 5.9M | 00.00% | Unchanged |
| Stonepine Capital Management, LLC |
| 0.31% | 0.65% | #3 | $2.0M | 2.7M | $1.6M | 2.6M | +45,175+1.73% | Add |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.17% | 0.14% | #5 | $1.6M | 2.1M | $1.4M | 2.3M | -122,111-5.40% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #22 | $1.2M | 1.6M | $955,187 | 1.5M | +27,594+1.79% | Add |
| DAFNA Capital Management LLC |
| 0.21% | 0.2% | #4 | $1.1M | 1.4M | $893,438 | 1.4M | 00.00% | Unchanged |
| PERKINS CAPITAL MANAGEMENT INC |
| 0.81% | 0.83% | #2 | $1.0M | 1.4M | $879,363 | 1.4M | -43,286-3.05% | Reduce |
| Sio Capital Management, LLC |
| 0.08% | 0.06% | #7 | $477,225 | 636,300 | $394,506 | 636,300 | 00.00% | Unchanged |
| WealthTrust Axiom LLC |
| 0.08% | 0.06% | #8 | $343,300 | 457,734 | $233,701 | 376,938 | +80,796+21.43% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #24 | $291,952 | 389,223 | $282,164 | 455,059 | -65,836-14.47% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #31 | $280,887 | 374,516 | $288,805 | 465,814 | -91,298-19.60% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #21 | $159,854 | 213,138 | $131,230 | 211,662 | +1,476+0.70% | Add |
| UP STRATEGIC WEALTH INVESTMENT ADVISORS LLC |
| 0.05% | 0.07% | #9 | $91,398 | 99,888 | $109,877 | 99,888 | 00.00% | Unchanged |
| Embree Financial Group |
| 0.01% | 0.01% | #12 | $68,180 | 90,906 | $73,271 | 118,178 | -27,272-23.08% | Reduce |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #29 | $56,093 | 74,790 | $108,127 | 174,398 | -99,608-57.12% | Reduce |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #26 | $50,775 | 67,700 | $30,814 | 49,700 | +18,000+36.22% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #35 | $47,537 | 63,383 | $39,297 | 63,383 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #19 | $43,575 | 58,100 | $32,612 | 52,600 | +5,500+10.46% | Add |
| PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #23 | $40,209 | 53,612 | $33,239 | 53,612 | 00.00% | Unchanged |
| Destiny Wealth Partners, LLC |
| 0.01% | <0.01% | #13 | $38,320 | 52,500 | $32,550 | 52,500 | 00.00% | Unchanged |
| Ducere Wealth Management LLC |
| 0.01% | 0.01% | #10 | $38,250 | 51,000 | $23,600 | 20,000 | +31,000+155.00% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | — | #33 | $36,933 | 49,245 | $0 | 0 | +49,245 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #32 | $25,100 | 33,466 | $656,905 | 1.1M | -1.0M-96.84% | Reduce |
| XTX Topco Ltd |
| <0.01% | <0.01% | #15 | $22,169 | 29,558 | $9,407 | 15,173 | +14,385+94.81% | Add |
| TD Waterhouse Canada Inc. |
| <0.01% | — | #20 | $16,560 | 23,000 | $0 | 0 | +23,000 | New Buy |
| PRIMORIS WEALTH ADVISORS, LLC |
| 0.01% | — | #11 | $15,225 | 20,300 | $0 | 0 | +20,300 | New Buy |
| GREAT VALLEY ADVISOR GROUP, INC. |
| <0.01% | <0.01% | #17 | $14,702 | 19,602 | $12,153 | 19,703 | -101-0.51% | Reduce |
| J.W. COLE ADVISORS, INC. |
| <0.01% | — | #18 | $12,188 | 16,250 | $0 | 0 | +16,250 | New Buy |
| Atom Investors LP |
| <0.01% | — | #14 | $11,605 | 15,473 | $0 | 0 | +15,473 | New Buy |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #25 | $11,121 | 14,828 | $0 | 0 | +14,828 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #16 | $10,209 | 13,612 | $548 | 884 | +12,728+1,439.82% | Add |
| HighTower Advisors, LLC |
| <0.01% | <0.01% | #27 | $8,400 | 11,200 | $6,944 | 11,200 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #36 | $7,787 | 10,383 | $0 | 0 | +10,383 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #34 | $3,453 | 4,604 | $2,854 | 4,604 | 00.00% | Unchanged |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #38 | $3,150 | 4,200 | $2,604 | 4,200 | 00.00% | Unchanged |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #28 | $1,493 | 1,991 | $1,234 | 1,991 | 00.00% | Unchanged |
| CITIGROUP INC |
| <0.01% | <0.01% | #39 | $1,331 | 1,774 | $465,000 | 750,000 | -748,226-99.76% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #37 | $957 | 1,276 | $88 | 143 | +1,133+792.31% | Add |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #30 | $226 | 301 | $187 | 301 | 00.00% | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #41 | $158 | 210 | $133 | 214 | -4-1.87% | Reduce |
| BARCLAYS PLC |
| <0.01% | — | #42 | $156 | 208 | $0 | 0 | +208 | New Buy |
| OSAIC HOLDINGS, INC. |
| <0.01% | — | #40 | $75 | 100 | $0 | 0 | +100 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #43 | $28 | 37 | $3,306 | 2,219 | -2,182-98.33% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #43 | $28 | 39 | $22 | 39 | 00.00% | Unchanged |
