| FMR LLC |
| 0.05% | 0.05% | #62 | $1.21B | 20.9M | $958.4M | 16.5M | +4.4M+26.44% | Add |
| Jupiter Topco LLC |
| 0.43% | — | #36 | $1.04B | 18.0M | $0 | 0 | +18.0M | New Buy |
| T. Rowe Price Investment Management, Inc. |
| 0.47% | 0.49% | #32 | $709.6M | 12.2M | $704.6M | 12.1M | +81,433+0.67% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #120 | $701.5M | 12.1M | $637.6M | 11.0M | +1.1M+9.99% | Add |
| RA CAPITAL MANAGEMENT, L.P. |
| 5.8% | 7.07% | #7 | $667.0M | 11.5M | $666.8M | 11.5M | 00.00% | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.06% | #55 | $407.0M | 7.0M | $326.3M | 5.6M | +1.4M+24.70% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #93 | $383.3M | 6.6M | $364.9M | 6.3M | +314,006+5.00% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #135 | $369.0M | 6.3M | $364.2M | 6.3M | +81,978+1.31% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #127 | $311.1M | 5.4M | $258.0M | 4.4M | +911,179+20.52% | Add |
| Deep Track Capital, LP |
| 3.64% | 4.08% | #8 | $250.0M | 4.3M | $249.9M | 4.3M | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #119 | $201.1M | 3.5M | $186.1M | 3.2M | +258,080+8.06% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #94 | $173.8M | 3.0M | $56.7M | 976,429 | +2.0M+206.12% | Add |
| Kynam Capital Management, LP |
| 9.39% | 10.48% | #3 | $169.9M | 2.9M | $169.8M | 2.9M | 00.00% | Unchanged |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.47% | 0.89% | #31 | $143.7M | 2.5M | $211.9M | 3.6M | -1.2M-32.19% | Reduce |
| Caligan Partners LP |
| 5.99% | 7.97% | #6 | $127.2M | 2.2M | $119.7M | 2.1M | +127,917+6.21% | Add |
| Paradigm Biocapital Advisors LP |
| 2.32% | 5.69% | #18 | $123.7M | 2.1M | $278.5M | 4.8M | -2.7M-55.61% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | <0.01% | #126 | $120.8M | 2.1M | $44.0M | 757,773 | +1.3M+174.29% | Add |
| Bellevue Group AG |
| 2.41% | 1.65% | #16 | $114.6M | 2.0M | $69.2M | 1.2M | +781,238+65.61% | Add |
| D. E. Shaw & Co., Inc. |
| 0.05% | 0.1% | #61 | $110.6M | 1.9M | $166.5M | 2.9M | -963,446-33.62% | Reduce |
| Caption Management, LLC |
| 0.46% | 0.24% | #33 | $98.6M | 1.7M | $40.9M | 703,200 | +993,700+141.31% | Add |
| MAVERICK CAPITAL LTD |
| 0.83% | 0.92% | #27 | $93.8M | 1.6M | $80.1M | 1.4M | +235,504+17.09% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #117 | $85.1M | 1.5M | $81.6M | 1.4M | +60,864+4.34% | Add |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 26.92% | 28.51% | #1 | $82.9M | 1.4M | $79.8M | 1.4M | +53,045+3.87% | Add |
| EVENTIDE ASSET MANAGEMENT, LLC |
| 1.07% | 1.32% | #23 | $80.2M | 1.4M | $79.8M | 1.4M | +5,927+0.43% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #149 | $80.0M | 1.4M | $75.6M | 1.3M | +75,724+5.82% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #129 | $74.4M | 1.3M | $66.5M | 1.1M | +135,703+11.86% | Add |
| NORGES BANK |
| 0.01% | <0.01% | #144 | $72.4M | 1.2M | $34.0M | 899,842 | +345,963+38.45% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #181 | $71.2M | 1.2M | $55.4M | 1.0M | +219,032+21.72% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.01% | <0.01% | #109 | $69.4M | 1.2M | $21.8M | 375,772 | +818,982+217.95% | Add |
| Polar Capital Holdings Plc |
| 0.16% | 0.29% | #46 | $68.9M | 1.2M | $82.9M | 1.4M | -239,845-16.82% | Reduce |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.89% | 0.54% | #25 | $66.8M | 1.1M | $42.0M | 723,319 | +425,444+58.82% | Add |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #178 | $62.7M | 1.1M | $70.7M | 1.2M | -138,045-11.34% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #113 | $54.1M | 930,642 | $48.9M | 842,273 | +88,369+10.49% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.07% | 0.03% | #54 | $51.2M | 880,000 | $20.3M | 350,000 | +530,000+151.43% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | 0.01% | #175 | $50.4M | 867,301 | $61.7M | 1.1M | -193,676-18.25% | Reduce |
| Saturn V Capital Management LP |
| 7.11% | 8.68% | #4 | $49.6M | 852,914 | $47.9M | 824,532 | +28,382+3.44% | Add |
| Capital Research Global Investors |
| 0.01% | 0.01% | #150 | $48.6M | 836,761 | $53.0M | 912,688 | -75,927-8.32% | Reduce |
| Novo Holdings A/S |
| 2.71% | 4.05% | #14 | $46.5M | 800,000 | $50.0M | 860,000 | -60,000-6.98% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #199 | $46.4M | 797,718 | $28.3M | 784,483 | +13,235+1.69% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.01% | #90 | $45.5M | 782,184 | $20.7M | 355,854 | +426,330+119.80% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #157 | $45.1M | 776,511 | $77.7M | 1.3M | -560,879-41.94% | Reduce |
| Clearbridge Investments, LLC |
| 0.04% | 0.01% | #79 | $43.7M | 751,999 | $7.5M | 128,377 | +623,622+485.77% | Add |
| Pictet Asset Management Holding SA |
| 0.04% | 0.04% | #75 | $40.4M | 694,719 | $40.7M | 700,311 | -5,592-0.80% | Reduce |
| Eversept Partners, LP |
| 1.9% | 2.83% | #20 | $36.6M | 629,952 | $53.7M | 924,193 | -294,241-31.84% | Reduce |
| FEDERATED HERMES, INC. |
| 0.05% | 0.05% | #65 | $34.9M | 601,161 | $32.9M | 566,828 | +34,333+6.06% | Add |
| ALGERT GLOBAL LLC |
| 0.36% | 0.32% | #39 | $30.0M | 515,343 | $21.2M | 363,984 | +151,359+41.58% | Add |
| Bank of New York Mellon Corp |
| <0.01% | 0.01% | #165 | $29.2M | 502,135 | $27.6M | 474,526 | +27,609+5.82% | Add |
| BROWN ADVISORY INC |
| 0.04% | 0.05% | #71 | $28.3M | 487,017 | $29.7M | 511,701 | -24,684-4.82% | Reduce |
| JENNISON ASSOCIATES LLC |
| 0.02% | 0.07% | #96 | $27.7M | 476,216 | $98.7M | 1.7M | -1.2M-71.95% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #158 | $27.7M | 476,004 | $27.5M | 473,363 | +2,641+0.56% | Add |
