| Venrock Adviser, LLC |
| 34.18% | 26.68% | #1 | $1.13B | 8.5M | $714.9M | 8.5M | 00.00% | Unchanged |
| BlackRock, Inc. |
| 0.01% | 0.01% | #142 | $730.9M | 5.5M | $343.9M | 4.1M | +1.4M+34.79% | Add |
| HBK INVESTMENTS L P |
| 3.7% | — | #16 | $378.3M | 2.9M | $0 | 0 | +2.9M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #157 | $341.4M | 2.6M | $210.6M | 2.5M | +70,024+2.80% | Add |
| FMR LLC |
| 0.01% | 0.04% | #128 | $330.9M | 2.5M | $779.6M | 9.3M | -6.8M-73.08% | Reduce |
| STATE STREET CORP |
| 0.01% | 0.01% | #152 | $305.0M | 2.3M | $182.1M | 2.2M | +134,779+6.23% | Add |
| BALYASNY ASSET MANAGEMENT L.P. |
| 0.36% | 0.05% | #57 | $287.4M | 2.2M | $36.9M | 438,654 | +1.7M+393.58% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.34% | 1.19% | #32 | $231.0M | 1.7M | $161.7M | 1.9M | -180,699-9.41% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.02% | 0.01% | #118 | $224.8M | 1.7M | $54.9M | 652,590 | +1.0M+159.48% | Add |
| GLAZER CAPITAL, LLC |
| 5.42% | — | #10 | $217.8M | 1.6M | $0 | 0 | +1.6M | New Buy |
| Paradigm Biocapital Advisors LP |
| 3.92% | 2.32% | #15 | $209.2M | 1.6M | $113.5M | 1.3M | +228,142+16.92% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.01% | <0.01% | #150 | $202.9M | 1.5M | $33.4M | 396,330 | +1.1M+285.73% | Add |
| MILLENNIUM MANAGEMENT LLC |
| 0.07% | <0.01% | #87 | $199.3M | 1.5M | $7.8M | 92,592 | +1.4M+1,521.63% | Add |
| Pentwater Capital Management LP |
| 1.16% | — | #35 | $189.1M | 1.4M | $0 | 0 | +1.4M | New Buy |
| MORGAN STANLEY |
| 0.01% | <0.01% | #145 | $188.7M | 1.4M | $18.5M | 464,963 | +956,718+205.76% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #149 | $174.6M | 1.3M | $102.5M | 1.2M | +97,579+8.02% | Add |
| PERCEPTIVE ADVISORS LLC |
| 2.61% | 2.53% | #21 | $173.6M | 1.3M | $129.7M | 1.5M | -232,271-15.08% | Reduce |
| Jupiter Topco LLC |
| 0.06% | — | #90 | $158.4M | 1.2M | $0 | 0 | +1.2M | New Buy |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #147 | $149.5M | 1.1M | $75.8M | 900,871 | +225,268+25.01% | Add |
| Affinity Asset Advisors, LLC |
| 5.92% | 5.59% | #8 | $131.0M | 987,000 | $108.2M | 1.3M | -297,926-23.19% | Reduce |
| MERCER GLOBAL ADVISORS INC /ADV |
| 0.16% | 0.1% | #71 | $124.9M | 941,283 | $70.0M | 831,428 | +109,855+13.21% | Add |
| First Light Asset Management, LLC |
| 7.5% | 4.35% | #5 | $123.5M | 930,289 | $48.5M | 576,684 | +353,605+61.32% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.07% | 0.6% | #89 | $101.2M | 762,183 | $867.0M | 10.3M | -9.5M-92.60% | Reduce |
| Kryger Capital LLC |
| 5.62% | — | #9 | $98.6M | 742,555 | $0 | 0 | +742,555 | New Buy |
| Qube Research & Technologies Ltd |
| 0.08% | — | #82 | $87.6M | 659,678 | $0 | 0 | +659,678 | New Buy |
| First Trust Capital Management L.P. |
| 4.8% | — | #12 | $83.0M | 625,182 | $0 | 0 | +625,182 | New Buy |
| Remedium Capital Partners, LLC |
| 17.24% | 17.47% | #3 | $77.9M | 586,691 | $49.1M | 583,591 | +3,100+0.53% | Add |
| SOROS FUND MANAGEMENT LLC |
| 0.92% | — | #38 | $74.9M | 564,500 | $0 | 0 | +564,500 | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.07% | #134 | $74.9M | 564,326 | $368.3M | 4.4M | -3.8M-87.10% | Reduce |
| ALLIANCEBERNSTEIN L.P. |
| 0.02% | 0.02% | #116 | $65.2M | 775,058 | $74.7M | 990,297 | -215,239-21.73% | Reduce |
| Woodline Partners LP |
| 0.19% | 0.08% | #66 | $61.7M | 464,622 | $22.0M | 261,120 | +203,502+77.93% | Add |
| WHITEBOX ADVISORS LLC |
| 0.78% | — | #40 | $59.7M | 450,001 | $0 | 0 | +450,001 | New Buy |
| NORTHERN TRUST CORP |
| 0.01% | <0.01% | #159 | $59.1M | 445,154 | $32.9M | 390,879 | +54,275+13.89% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #156 | $58.9M | 443,658 | $35.4M | 420,684 | +22,974+5.46% | Add |
| AQR Arbitrage LLC |
| 0.81% | — | #39 | $57.1M | 429,900 | $0 | 0 | +429,900 | New Buy |
| Magnetar Financial LLC |
| 0.48% | — | #49 | $53.0M | 399,123 | $0 | 0 | +399,123 | New Buy |
| Man Group plc |
| 0.08% | 0.01% | #81 | $52.7M | 397,000 | $3.5M | 41,815 | +355,185+849.42% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #137 | $52.2M | 393,180 | $31.1M | 368,961 | +24,219+6.56% | Add |
| Opaleye Management Inc. |
| 4.69% | 4.32% | #13 | $51.8M | 390,000 | $32.8M | 390,000 | 00.00% | Unchanged |
| PICTON MAHONEY ASSET MANAGEMENT |
| 0.36% | — | #58 | $48.4M | 365,000 | $0 | 0 | +365,000 | New Buy |
| TIG Advisors, LLC |
| 2.14% | — | #23 | $48.3M | 364,250 | $0 | 0 | +364,250 | New Buy |
| FRANKLIN RESOURCES INC |
| 0.01% | 0.01% | #146 | $48.2M | 363,379 | $34.1M | 405,538 | -42,159-10.40% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | 0.01% | #197 | $47.9M | 359,250 | $87.4M | 1.1M | -751,220-67.65% | Reduce |
| Cinctive Capital Management LP |
| 1.71% | — | #26 | $46.5M | 350,165 | $0 | 0 | +350,165 | New Buy |
| LOOMIS SAYLES & CO L P |
| 0.06% | 0.04% | #94 | $45.0M | 338,664 | $30.5M | 362,781 | -24,117-6.65% | Reduce |
| Polar Asset Management Partners Inc. |
| 0.7% | — | #44 | $42.8M | 322,667 | $0 | 0 | +322,667 | New Buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.38% | 0.92% | #55 | $40.3M | 303,739 | $89.6M | 1.1M | -760,744-71.47% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #189 | $40.3M | 303,656 | $26.8M | 318,399 | -14,743-4.63% | Reduce |
| NEXPOINT ASSET MANAGEMENT, L.P. |
| 2.66% | — | #19 | $39.8M | 299,940 | $0 | 0 | +299,940 | New Buy |
| Fairmount Funds Management LLC |
| 2.62% | 1.82% | #20 | $39.6M | 298,647 | $25.1M | 298,647 | 00.00% | Unchanged |
