| Stonepine Capital Management, LLC |
| 2.19% | 0.82% | #1 | $14.3M | 14.3M | $2.0M | 3.7M | +10.6M+284.07% | Add |
| Bleichroeder LP |
| 0.36% | 0.36% | #2 | $2.0M | 3.8M | $2.1M | 3.8M | 00.00% | Unchanged |
| Cable Car Capital, LP |
| 0.24% | 0.24% | #4 | $729,734 | 1.3M | $729,734 | 1.3M | 00.00% | Unchanged |
| CM Management, LLC |
| 0.18% | 0.07% | #5 | $287,155 | 550,000 | $82,095 | 150,000 | +400,000+266.67% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #16 | $263,291 | 504,292 | $1,403 | 845 | +503,447+59,579.53% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #21 | $179,486 | 343,842 | $204,756 | 374,326 | -30,484-8.14% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #17 | $153,036 | 293,097 | $92,133 | 168,327 | +124,770+74.12% | Add |
| M28 Capital Management LP |
| 0.32% | 0.29% | #3 | $148,741 | 284,889 | $155,920 | 284,889 | 00.00% | Unchanged |
| FLPUTNAM INVESTMENT MANAGEMENT CO |
| <0.01% | — | #9 | $128,306 | 245,750 | $0 | 0 | +245,750 | New Buy |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.01% | 0.17% | #6 | $98,996 | 98,996 | $1.1M | 2.0M | -1.9M-95.04% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #15 | $74,123 | 141,972 | $200,717 | 366,740 | -224,768-61.29% | Reduce |
| XTX Topco Ltd |
| <0.01% | — | #11 | $56,470 | 108,160 | $0 | 0 | +108,160 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #20 | $50,054 | 95,870 | $5,742 | 10,492 | +85,378+813.74% | Add |
| MAVERICK CAPITAL LTD |
| <0.01% | <0.01% | #13 | $49,554 | 49,554 | $6,194 | 49,554 | 00.00% | Unchanged |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #18 | $32,189 | 61,664 | $33,730 | 61,664 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #27 | $27,846 | 53,334 | $29,272 | 53,484 | -150-0.28% | Reduce |
| Focused Wealth Management, Inc |
| <0.01% | 0.01% | #8 | $26,131 | 50,049 | $60,064 | 109,746 | -59,697-54.40% | Reduce |
| GSA CAPITAL PARTNERS LLP |
| <0.01% | — | #10 | $11,883 | 22,760 | $0 | 0 | +22,760 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #28 | $10,990 | 21,049 | $11,520 | 21,049 | 00.00% | Unchanged |
| FRANKLIN STREET ADVISORS INC /NC |
| <0.01% | <0.01% | #12 | $10,442 | 20,000 | $10,946 | 20,000 | 00.00% | Unchanged |
| LPL Financial LLC |
| <0.01% | <0.01% | #23 | $7,819 | 14,977 | $13,123 | 23,977 | -9,000-37.54% | Reduce |
| Dauntless Investment Group, LLC |
| <0.01% | 0.24% | #7 | $5,222 | 10,001 | $362,299 | 658,725 | -648,724-98.48% | Reduce |
| BARCLAYS PLC |
| <0.01% | — | #25 | $3,641 | 6,973 | $0 | 0 | +6,973 | New Buy |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #19 | $1,356 | 2,597 | $1,421 | 2,597 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #24 | $785 | 1,510 | $33 | 60 | +1,450+2,416.67% | Add |
| Axiom Investment Management LLC |
| <0.01% | — | #14 | $574 | 1,100 | $0 | 0 | +1,100 | New Buy |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #29 | $235 | 450 | $246 | 450 | 00.00% | Unchanged |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #31 | $120 | 120 | $67 | 120 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #33 | $108 | 108 | $55 | 108 | 00.00% | Unchanged |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #34 | $29 | 55 | $30 | 55 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #35 | $24 | 46 | $39 | 71 | -25-35.21% | Reduce |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #30 | $8 | 15 | $10 | 19 | -4-21.05% | Reduce |
| Blue Trust, Inc. |
| <0.01% | <0.01% | #32 | $2 | 4 | $2 | 4 | 00.00% | Unchanged |
| VIMA LLC |
| <0.01% | — | #22 | $2 | 3 | $0 | 0 | +3 | New Buy |
| MPWM ADVISORY SOLUTIONS, LLC |
| <0.01% | <0.01% | #26 | $1 | 2 | $1 | 2 | 00.00% | Unchanged |
