| Opaleye Management Inc. |
| 3.36% | 5.22% | #2 | $37.1M | 500,000 | $39.6M | 500,000 | 00.00% | Unchanged |
| GREAT POINT PARTNERS LLC |
| 3.84% | 5% | #1 | $20.3M | 274,363 | $21.7M | 274,363 | 00.00% | Unchanged |
| Phoenix Financial Ltd. |
| 0.07% | 0.16% | #8 | $10.8M | 146,147 | $16.7M | 210,849 | -64,702-30.69% | Reduce |
| Trails Edge Capital Partners, LP |
| 1.64% | 1.55% | #3 | $10.3M | 139,445 | $6.8M | 85,496 | +53,949+63.10% | Add |
| Affinity Asset Advisors, LLC |
| 0.28% | 0.14% | #5 | $6.3M | 84,900 | $2.8M | 35,000 | +49,900+142.57% | Add |
| Squadron Capital Management LLC |
| 1.2% | 0.9% | #4 | $3.9M | 52,000 | $2.5M | 31,000 | +21,000+67.74% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #15 | $2.4M | 32,556 | $2.9M | 37,145 | -4,589-12.35% | Reduce |
| GILDER GAGNON HOWE & CO LLC |
| 0.02% | — | #11 | $1.7M | 22,500 | $0 | 0 | +22,500 | New Buy |
| Stonepine Capital Management, LLC |
| 0.16% | 0.88% | #6 | $1.1M | 14,469 | $2.2M | 27,778 | -13,309-47.91% | Reduce |
| Yelin Lapidot Holdings Management Ltd. |
| 0.15% | 0.29% | #7 | $769,870 | 10,384 | $1.4M | 17,753 | -7,369-41.51% | Reduce |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #20 | $619,588 | 8,357 | $566,581 | 7,152 | +1,205+16.85% | Add |
| MENORA MIVTACHIM HOLDINGS LTD. |
| <0.01% | <0.01% | #13 | $564,280 | 7,611 | $602,943 | 7,611 | 00.00% | Unchanged |
| HRT FINANCIAL LP |
| <0.01% | <0.01% | #14 | $463,820 | 6,256 | $254,000 | 3,215 | +3,041+94.59% | Add |
| NAVELLIER & ASSOCIATES INC |
| 0.03% | — | #9 | $428,900 | 5,785 | $0 | 0 | +5,785 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #21 | $341,563 | 4,607 | $127,240 | 4,365 | +242+5.54% | Add |
| LPL Financial LLC |
| <0.01% | <0.01% | #19 | $289,443 | 3,904 | $274,814 | 3,469 | +435+12.54% | Add |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #18 | $247,776 | 3,342 | $0 | 0 | +3,342 | New Buy |
| XTX Topco Ltd |
| <0.01% | 0.01% | #12 | $220,492 | 2,974 | $634,552 | 8,010 | -5,036-62.87% | Reduce |
| TWO SIGMA SECURITIES, LLC |
| 0.02% | — | #10 | $200,771 | 2,708 | $0 | 0 | +2,708 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #24 | $70,655 | 953 | $75,497 | 953 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #22 | $30,842 | 416 | $54,978 | 694 | -278-40.06% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #16 | $7,414 | 100 | $0 | 0 | +100 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #17 | $5,338 | 72 | $5,704 | 72 | 00.00% | Unchanged |
| Allworth Financial LP |
| <0.01% | <0.01% | #23 | $371 | 5 | $397 | 5 | 00.00% | Unchanged |
