| ARCH Venture Management, LLC |
| 4.14% | 9.62% | #2 | $45.5M | 3.2M | $65.1M | 3.2M | 00.00% | Unchanged |
| GSK plc |
| 3.53% | 5.06% | #3 | $21.3M | 1.5M | $30.3M | 1.5M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $11.1M | 786,774 | $14.4M | 718,155 | +68,619+9.55% | Add |
| Orland Properties Ltd |
| 5.25% | 5.67% | #1 | $10.6M | 754,698 | $15.1M | 754,698 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #50 | $10.2M | 724,342 | $3.8M | 191,820 | +532,522+277.62% | Add |
| Decheng Capital LLC |
| 1.33% | 2.1% | #6 | $9.7M | 692,050 | $13.9M | 692,050 | 00.00% | Unchanged |
| Almitas Capital LLC |
| 1.9% | 2.62% | #4 | $8.2M | 581,407 | $11.6M | 577,807 | +3,600+0.62% | Add |
| Foresite Capital Management V, LLC |
| 1.85% | 3.53% | #5 | $6.7M | 476,386 | $9.6M | 477,078 | -692-0.15% | Reduce |
| Alphabet Inc. |
| 0.14% | 0.15% | #12 | $5.9M | 293,256 | $5.9M | 293,256 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $5.2M | 367,473 | $9.2M | 458,905 | -91,432-19.92% | Reduce |
| Opaleye Management Inc. |
| 0.44% | 0.21% | #9 | $4.8M | 344,025 | $1.6M | 79,097 | +264,928+334.94% | Add |
| venBio Partners LLC |
| 0.91% | 2.41% | #7 | $4.7M | 337,697 | $6.8M | 337,697 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #42 | $4.4M | 310,636 | $3.4M | 166,980 | +143,656+86.03% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #54 | $2.6M | 185,322 | $1.5M | 72,522 | +112,800+155.54% | Add |
| HSG Holding Ltd |
| 0.18% | <0.01% | #11 | $2.1M | 152,299 | $73,104 | 152,299 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #21 | $1.8M | 130,190 | $2.3M | 116,411 | +13,779+11.84% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $1.7M | 118,500 | $607,417 | 30,280 | +88,220+291.35% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #24 | $1.6M | 110,531 | $1.1M | 55,110 | +55,421+100.56% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #45 | $1.5M | 107,570 | $1.7M | 85,971 | +21,599+25.12% | Add |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #25 | $1.5M | 106,300 | $3.0M | 148,516 | -42,216-28.43% | Reduce |
| Velan Capital Investment Management LP |
| 0.9% | 1.28% | #8 | $1.5M | 105,000 | $2.0M | 102,000 | +3,000+2.94% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #40 | $1.3M | 93,095 | $1.7M | 86,925 | +6,170+7.10% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #58 | $1.3M | 91,891 | $461,681 | 23,015 | +68,876+299.27% | Add |
| MIC Capital Management UK LLP |
| 0.31% | 0.5% | #10 | $1.2M | 87,028 | $1.7M | 87,028 | 00.00% | Unchanged |
| GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #52 | $1.2M | 86,779 | $2.3M | 114,491 | -27,712-24.20% | Reduce |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #47 | $957,066 | 68,315 | $958,999 | 47,888 | +20,427+42.66% | Add |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #26 | $839,459 | 59,748 | $0 | 0 | +59,748 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $753,010 | 53,595 | $7.9M | 393,462 | -339,867-86.38% | Reduce |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #31 | $743,624 | 52,927 | $232,395 | 11,585 | +41,342+356.86% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #60 | $646,455 | 46,011 | $1.3M | 63,893 | -17,882-27.99% | Reduce |
| Squarepoint Ops LLC |
| <0.01% | <0.01% | #29 | $594,624 | 42,322 | $387,038 | 19,294 | +23,028+119.35% | Add |
| Ikarian Capital, LLC |
| 0.06% | 0.07% | #14 | $577,188 | 41,081 | $824,084 | 41,081 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #64 | $563,405 | 40,100 | $6.2M | 310,198 | -270,098-87.07% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #69 | $520,553 | 37,050 | $601,204 | 37,020 | +30+0.08% | Add |
| HRT FINANCIAL LP |
| <0.01% | — | #28 | $513,879 | 36,575 | $0 | 0 | +36,575 | New Buy |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #65 | $430,731 | 30,657 | $264,000 | 13,128 | +17,529+133.52% | Add |
| CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #43 | $413,225 | 29,411 | $589,985 | 29,411 | 00.00% | Unchanged |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | — | #15 | $368,461 | 26,225 | $0 | 0 | +26,225 | New Buy |
| Point72 Asset Management, L.P. |
| <0.01% | <0.01% | #36 | $366,424 | 26,080 | $427,118 | 21,292 | +4,788+22.49% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #62 | $365,048 | 25,982 | $638,188 | 31,814 | -5,832-18.33% | Reduce |
| Bank of New York Mellon Corp |
| <0.01% | — | #59 | $346,656 | 24,673 | $0 | 0 | +24,673 | New Buy |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #49 | $344,787 | 24,540 | $320,378 | 15,971 | +8,569+53.65% | Add |
| Jump Financial, LLC |
| <0.01% | 0.01% | #22 | $308,482 | 21,956 | $403,667 | 20,123 | +1,833+9.11% | Add |
| Clearstead Advisors, LLC |
| <0.01% | 0.01% | #20 | $280,410 | 19,958 | $800,715 | 39,916 | -19,958-50.00% | Reduce |
| EntryPoint Capital, LLC |
| 0.07% | — | #13 | $272,710 | 19,410 | $0 | 0 | +19,410 | New Buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #16 | $252,900 | 18,000 | $361,080 | 18,000 | 00.00% | Unchanged |
| Susquehanna Portfolio Strategies, LLC |
| <0.01% | 0.01% | #17 | $251,144 | 17,875 | $417,248 | 20,800 | -2,925-14.06% | Reduce |
| Allspring Global Investments Holdings, LLC |
| <0.01% | — | #38 | $226,837 | 16,145 | $0 | 0 | +16,145 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | — | #48 | $217,234 | 15,462 | $0 | 0 | +15,462 | New Buy |
| Invesco Ltd. |
| <0.01% | — | #75 | $195,492 | 13,914 | $0 | 0 | +13,914 | New Buy |
