| BlackRock, Inc. |
| 0.02% | 0.02% | #112 | $1.26B | 10.3M | $1.03B | 9.8M | +528,468+5.40% | Add |
| FARALLON CAPITAL MANAGEMENT, L.L.C. |
| 3.59% | 3.81% | #8 | $778.2M | 6.3M | $669.2M | 6.3M | 00.00% | Unchanged |
| RTW INVESTMENTS, LP |
| 5.3% | 5.31% | #4 | $620.4M | 5.1M | $533.2M | 5.1M | +2,122+0.04% | Add |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | — | #106 | $444.9M | 3.6M | $0 | 0 | +3.6M | New Buy |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.07% | 0.07% | #66 | $418.8M | 3.4M | $379.4M | 3.6M | -182,863-5.08% | Reduce |
| UBS Group AG |
| 0.05% | 0.08% | #74 | $416.7M | 3.4M | $545.7M | 5.2M | -1.8M-34.35% | Reduce |
| STATE STREET CORP |
| 0.01% | 0.01% | #132 | $407.2M | 3.3M | $328.5M | 3.1M | +204,805+6.57% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | — | #166 | $349.8M | 2.9M | $0 | 0 | +2.9M | New Buy |
| JOHNSON & JOHNSON |
| 37.59% | 39.57% | #1 | $300.2M | 2.4M | $258.1M | 2.4M | 00.00% | Unchanged |
| Invesco Ltd. |
| 0.02% | 0.03% | #100 | $286.9M | 2.3M | $228.2M | 2.2M | +175,997+8.13% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #94 | $263.5M | 2.1M | $175.5M | 1.7M | +484,165+29.07% | Add |
| Jupiter Topco LLC |
| 0.11% | — | #54 | $261.0M | 2.1M | $0 | 0 | +2.1M | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #135 | $213.5M | 1.7M | $176.0M | 1.7M | +71,838+4.30% | Add |
| Woodline Partners LP |
| 0.54% | 0.56% | #25 | $173.3M | 1.4M | $149.1M | 1.4M | 00.00% | Unchanged |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #142 | $162.4M | 1.3M | $136.5M | 1.3M | +29,064+2.24% | Add |
| JENNISON ASSOCIATES LLC |
| 0.08% | 0.08% | #62 | $141.2M | 1.2M | $113.0M | 1.1M | +79,670+7.43% | Add |
| PERCEPTIVE ADVISORS LLC |
| 1.81% | 2.54% | #13 | $120.4M | 981,879 | $129.7M | 1.2M | -249,000-20.23% | Reduce |
| ADAR1 Capital Management, LLC |
| 5.43% | 6.17% | #3 | $117.8M | 960,863 | $104.8M | 994,119 | -33,256-3.35% | Reduce |
| MORGAN STANLEY |
| 0.01% | <0.01% | #185 | $111.1M | 905,992 | $51.0M | 768,359 | +137,633+17.91% | Add |
| Alyeska Investment Group, L.P. |
| 0.28% | 0.18% | #40 | $109.0M | 889,298 | $62.5M | 593,197 | +296,101+49.92% | Add |
| Hood River Capital Management LLC |
| 0.78% | 0.88% | #22 | $108.2M | 882,738 | $87.4M | 829,285 | +53,453+6.45% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #154 | $99.6M | 812,852 | $82.1M | 778,945 | +33,907+4.35% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.52% | 0.56% | #26 | $89.6M | 731,053 | $76.0M | 720,928 | +10,125+1.40% | Add |
| Clearbridge Investments, LLC |
| 0.07% | 0.06% | #64 | $88.9M | 725,335 | $65.5M | 621,820 | +103,515+16.65% | Add |
| FMR LLC |
| <0.01% | <0.01% | #215 | $82.4M | 672,186 | $69.8M | 661,997 | +10,189+1.54% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #148 | $81.7M | 666,105 | $62.0M | 587,968 | +78,137+13.29% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.03% | 0.03% | #85 | $73.4M | 598,600 | $56.6M | 537,320 | +61,280+11.40% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #147 | $71.6M | 583,774 | $58.3M | 552,956 | +30,818+5.57% | Add |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.06% | 0.05% | #70 | $70.1M | 571,618 | $47.9M | 454,383 | +117,235+25.80% | Add |
| Pictet Asset Management Holding SA |
| 0.07% | 0.06% | #67 | $69.6M | 567,990 | $61.2M | 581,083 | -13,093-2.25% | Reduce |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #130 | $63.7M | 520,032 | $14.5M | 137,871 | +382,161+277.19% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | — | #133 | $53.7M | 437,747 | $0 | 0 | +437,747 | New Buy |
| LORD, ABBETT & CO. LLC |
| 0.14% | 0.06% | #50 | $48.9M | 398,994 | $17.2M | 163,459 | +235,535+144.09% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.02% | 0.02% | #99 | $47.2M | 385,262 | $38.8M | 367,822 | +17,440+4.74% | Add |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #170 | $43.9M | 358,300 | $36.0M | 341,465 | +16,835+4.93% | Add |
| Caption Management, LLC |
| 0.2% | 0.08% | #44 | $43.7M | 356,800 | $14.4M | 136,600 | +220,200+161.20% | Add |
| Neuberger Berman Group LLC |
| 0.02% | 0.01% | #96 | $37.1M | 302,427 | $14.9M | 141,441 | +160,986+113.82% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #117 | $37.0M | 301,472 | $20.5M | 194,530 | +106,942+54.97% | Add |
| 683 Capital Management, LLC |
| 1.75% | 2.04% | #14 | $35.5M | 290,000 | $39.0M | 370,100 | -80,100-21.64% | Reduce |
| Nuveen, LLC |
| 0.01% | <0.01% | #157 | $34.8M | 284,085 | $13.5M | 127,914 | +156,171+122.09% | Add |
| Stephens Investment Management Group LLC |
| 0.37% | — | #32 | $34.5M | 281,832 | $0 | 0 | +281,832 | New Buy |
| BNP Paribas Asset Management Holding S.A. |
| 0.03% | — | #86 | $31.9M | 259,972 | $0 | 0 | +259,972 | New Buy |
| Eagle Health Investments LP |
| 5.05% | 3.31% | #5 | $30.4M | 248,322 | $18.9M | 179,322 | +69,000+38.48% | Add |
| NEXTBio Capital Management LP |
| 12.37% | 11.24% | #2 | $26.9M | 219,333 | $24.2M | 229,619 | -10,286-4.48% | Reduce |
| SEGALL BRYANT & HAMILL, LLC |
| 0.31% | 0.32% | #33 | $26.3M | 214,724 | $22.4M | 212,714 | +2,010+0.94% | Add |
| SEB Asset Management AB |
| 0.1% | 0.1% | #56 | $25.7M | 209,963 | $24.5M | 232,416 | -22,453-9.66% | Reduce |
| Duquesne Family Office LLC |
| 0.49% | 0.5% | #28 | $25.6M | 208,900 | $16.8M | 159,700 | +49,200+30.81% | Add |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.07% | 0.07% | #68 | $25.5M | 207,688 | $22.2M | 210,280 | -2,592-1.23% | Reduce |
| CITIGROUP INC |
| 0.01% | 0.01% | #161 | $24.4M | 198,668 | $16.7M | 158,711 | +39,957+25.18% | Add |
| ORBIMED ADVISORS LLC |
| 0.44% | 0.09% | #30 | $23.5M | 192,100 | $4.4M | 42,100 | +150,000+356.29% | Add |
