| Jupiter Topco LLC |
| 0.47% | — | #40 | $1.15B | 3.4M | $0 | 0 | +3.4M | New Buy |
| FMR LLC |
| 0.03% | 0.04% | #100 | $775.7M | 2.3M | $696.2M | 2.2M | +155,964+7.22% | Add |
| BlackRock, Inc. |
| 0.01% | 0.01% | #141 | $767.5M | 2.3M | $749.1M | 2.3M | -32,344-1.39% | Reduce |
| PERCEPTIVE ADVISORS LLC |
| 10.23% | 12.82% | #6 | $681.6M | 2.0M | $656.0M | 2.0M | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 2.94% | 3.24% | #17 | $587.0M | 1.8M | $564.9M | 1.8M | 00.00% | Unchanged |
| Orbis Allan Gray Ltd |
| 1.76% | 3.36% | #25 | $512.2M | 1.5M | $796.6M | 2.5M | -942,692-38.13% | Reduce |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.01% | #116 | $447.0M | 1.3M | $243.8M | 756,748 | +578,437+76.44% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #153 | $413.6M | 1.2M | $393.7M | 1.2M | +13,355+1.09% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #146 | $343.7M | 1.0M | $284.9M | 884,238 | +142,205+16.08% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.48% | 0.41% | #39 | $340.0M | 1.0M | $262.8M | 815,739 | +199,741+24.49% | Add |
| DEERFIELD MANAGEMENT COMPANY, L.P. |
| 3.36% | 3.66% | #14 | $322.5M | 963,351 | $310.4M | 963,351 | 00.00% | Unchanged |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 1.86% | 2.25% | #22 | $321.1M | 959,048 | $305.8M | 949,225 | +9,823+1.03% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #102 | $315.7M | 942,999 | $203.3M | 630,852 | +312,147+49.48% | Add |
| MORGAN STANLEY |
| 0.02% | <0.01% | #129 | $285.9M | 854,112 | $34.1M | 643,495 | +210,617+32.73% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #132 | $250.5M | 748,039 | $209.8M | 650,904 | +97,135+14.92% | Add |
| Cormorant Asset Management, LP |
| 10.88% | 14.33% | #4 | $214.3M | 640,000 | $285.3M | 885,500 | -245,500-27.72% | Reduce |
| GOLDMAN SACHS GROUP INC |
| 0.02% | 0.03% | #126 | $183.7M | 548,830 | $229.0M | 710,734 | -161,904-22.78% | Reduce |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #138 | $183.1M | 546,930 | $172.2M | 534,604 | +12,326+2.31% | Add |
| Invesco Ltd. |
| 0.01% | <0.01% | #130 | $180.0M | 537,548 | $19.8M | 61,397 | +476,151+775.53% | Add |
| Hood River Capital Management LLC |
| 1.03% | 1.16% | #32 | $142.3M | 425,167 | $115.5M | 358,618 | +66,549+18.56% | Add |
| NORGES BANK |
| 0.01% | <0.01% | #140 | $116.2M | 346,969 | $3.2M | 84,200 | +262,769+312.08% | Add |
| FRANKLIN RESOURCES INC |
| 0.02% | 0.02% | #111 | $109.5M | 327,124 | $89.0M | 276,123 | +51,001+18.47% | Add |
| Pictet Asset Management Holding SA |
| 0.09% | 0.1% | #72 | $98.0M | 291,689 | $91.4M | 286,644 | +5,045+1.76% | Add |
| Polar Capital Holdings Plc |
| 0.22% | — | #53 | $93.5M | 279,131 | $0 | 0 | +279,131 | New Buy |
| Vivo Capital, LLC |
| 8.29% | 9.08% | #8 | $90.8M | 271,116 | $109.2M | 338,895 | -67,779-20.00% | Reduce |
| Logos Global Management LP |
| 3.75% | 4.58% | #13 | $87.0M | 260,000 | $91.8M | 285,000 | -25,000-8.77% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #151 | $80.6M | 240,887 | $73.4M | 227,934 | +12,953+5.68% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.04% | 0.02% | #99 | $79.5M | 237,315 | $41.3M | 128,254 | +109,061+85.04% | Add |
| ORBIMED ADVISORS LLC |
| 1.45% | 1.1% | #26 | $77.0M | 230,100 | $55.6M | 172,500 | +57,600+33.39% | Add |
| Caption Management, LLC |
| 0.35% | 0.39% | #45 | $75.3M | 224,800 | $67.3M | 209,000 | +15,800+7.56% | Add |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #148 | $73.7M | 220,008 | $69.4M | 215,447 | +4,561+2.12% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.24% | <0.01% | #50 | $73.3M | 218,898 | $213,290 | 662 | +218,236+32,966.16% | Add |
| Verition Fund Management LLC |
| 0.09% | — | #75 | $67.3M | 201,100 | $0 | 0 | +201,100 | New Buy |
| Woodline Partners LP |
| 0.21% | 0.24% | #56 | $67.0M | 200,013 | $64.4M | 200,013 | 00.00% | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.01% | 0.01% | #185 | $66.4M | 198,394 | $46.4M | 144,117 | +54,277+37.66% | Add |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.02% | #103 | $63.1M | 188,409 | $46.1M | 143,082 | +45,327+31.68% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #131 | $63.0M | 188,161 | $54.7M | 169,902 | +18,259+10.75% | Add |
| Affinity Asset Advisors, LLC |
| 2.8% | 2.83% | #18 | $61.9M | 185,000 | $54.8M | 170,000 | +15,000+8.82% | Add |
| Soleus Capital Management, L.P. |
| 2.05% | 4.31% | #21 | $59.4M | 177,517 | $106.5M | 330,517 | -153,000-46.29% | Reduce |
| Aberdeen Group plc |
| 0.08% | 0.09% | #81 | $55.7M | 166,399 | $55.6M | 172,484 | -6,085-3.53% | Reduce |
| T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.04% | #98 | $53.7M | 160,477 | $56.5M | 175,237 | -14,760-8.42% | Reduce |
| Qube Research & Technologies Ltd |
| 0.05% | 0.05% | #93 | $51.0M | 152,475 | $41.3M | 128,228 | +24,247+18.91% | Add |
| MARSHALL WACE, LLP |
| 0.04% | 0.01% | #96 | $45.9M | 137,008 | $14.5M | 45,149 | +91,859+203.46% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #183 | $43.9M | 131,046 | $34.9M | 108,446 | +22,600+20.84% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.01% | 0.01% | #170 | $42.1M | 125,867 | $56.2M | 174,350 | -48,483-27.81% | Reduce |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.04% | 0.01% | #97 | $40.9M | 122,227 | $9.1M | 28,134 | +94,093+334.45% | Add |
| 683 Capital Management, LLC |
| 1.82% | 1.9% | #23 | $37.0M | 110,400 | $36.3M | 112,700 | -2,300-2.04% | Reduce |
| Nuveen, LLC |
| 0.01% | 0.01% | #155 | $36.2M | 108,032 | $23.2M | 72,043 | +35,989+49.95% | Add |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ |
| 0.01% | <0.01% | #137 | $36.0M | 107,409 | $2.4M | 7,388 | +100,021+1,353.83% | Add |
| Nantahala Capital Management, LLC |
| 1.11% | — | #30 | $33.5M | 100,000 | $0 | 0 | +100,000 | New Buy |
