| BlackRock, Inc. |
| 0.02% | 0.02% | #132 | $1.53B | 29.2M | $1.00B | 28.3M | +921,329+3.25% | Add |
| BAKER BROS. ADVISORS LP |
| 2.63% | 2.03% | #11 | $524.6M | 10.0M | $354.0M | 10.0M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #133 | $497.3M | 9.5M | $336.3M | 9.5M | -20,294-0.21% | Reduce |
| STATE STREET CORP |
| 0.01% | 0.01% | #157 | $480.0M | 9.2M | $334.7M | 9.5M | -304,711-3.22% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #197 | $393.7M | 7.5M | $262.6M | 7.4M | +87,628+1.18% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.02% | #115 | $353.0M | 6.7M | $164.9M | 4.7M | +2.1M+44.44% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| 0.47% | 0.34% | #39 | $338.5M | 6.5M | $217.8M | 6.2M | +300,500+4.88% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #163 | $234.7M | 4.5M | $147.9M | 4.2M | +295,609+7.07% | Add |
| DIMENSIONAL FUND ADVISORS LP |
| 0.04% | 0.03% | #106 | $219.8M | 4.2M | $159.9M | 4.5M | -327,505-7.24% | Reduce |
| Deep Track Capital, LP |
| 3.05% | 2.07% | #8 | $209.6M | 4.0M | $127.0M | 3.6M | +409,677+11.41% | Add |
| AMERICAN CENTURY COMPANIES INC |
| 0.09% | 0.11% | #72 | $207.2M | 4.0M | $214.7M | 6.1M | -2.1M-34.88% | Reduce |
| Holocene Advisors, LP |
| 0.47% | 0.2% | #38 | $207.0M | 4.0M | $81.9M | 2.3M | +1.6M+70.52% | Add |
| Commodore Capital LP |
| 9.36% | 8.59% | #1 | $157.2M | 3.0M | $148.5M | 4.2M | -1.2M-28.57% | Reduce |
| WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.02% | #127 | $147.5M | 2.8M | $105.0M | 3.0M | -155,362-5.23% | Reduce |
| PRIMECAP MANAGEMENT CO/CA/ |
| 0.08% | 0.07% | #78 | $132.5M | 2.5M | $89.8M | 2.5M | -11,310-0.45% | Reduce |
| FIRST TRUST ADVISORS LP |
| 0.07% | 0.08% | #80 | $126.8M | 2.4M | $105.0M | 3.0M | -547,769-18.45% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.01% | #147 | $122.3M | 2.3M | $79.1M | 2.2M | +98,361+4.40% | Add |
| Nuveen, LLC |
| 0.03% | 0.02% | #119 | $121.8M | 2.3M | $87.0M | 2.5M | -136,372-5.54% | Reduce |
| NORGES BANK |
| 0.01% | 0.01% | #169 | $113.0M | 2.2M | $63.3M | 1.9M | +240,268+12.54% | Add |
| BVF INC/IL |
| 2.89% | 2.25% | #10 | $112.9M | 2.2M | $70.7M | 2.0M | +154,704+7.74% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #187 | $106.0M | 2.0M | $66.6M | 1.9M | +141,806+7.53% | Add |
| Bain Capital Life Sciences Investors, LLC |
| 6.04% | 1.95% | #2 | $101.5M | 1.9M | $21.6M | 610,000 | +1.3M+217.69% | Add |
| CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #167 | $99.1M | 1.9M | $82.4M | 2.3M | -439,383-18.85% | Reduce |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #170 | $96.0M | 1.8M | $60.0M | 1.7M | +134,537+7.93% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #238 | $91.8M | 1.8M | $46.5M | 1.6M | +200,383+12.92% | Add |
| RTW INVESTMENTS, LP |
| 0.75% | 0.59% | #29 | $87.6M | 1.7M | $59.1M | 1.7M | 00.00% | Unchanged |
| LOOMIS SAYLES & CO L P |
| 0.1% | 0.08% | #69 | $83.1M | 1.6M | $63.1M | 1.8M | -199,063-11.15% | Reduce |
| Affinity Asset Advisors, LLC |
| 3.26% | 2.47% | #7 | $72.0M | 1.4M | $47.7M | 1.4M | +25,000+1.85% | Add |
| ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.1% | — | #70 | $71.7M | 1.4M | $0 | 0 | +1.4M | New Buy |
| D. E. Shaw & Co., Inc. |
| 0.03% | 0.02% | #117 | $68.7M | 1.3M | $25.1M | 710,297 | +601,734+84.72% | Add |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.38% | 0.21% | #42 | $64.9M | 1.2M | $28.0M | 791,963 | +446,846+56.42% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.01% | #159 | $61.7M | 1.2M | $39.9M | 1.1M | +48,709+4.31% | Add |
| FRANKLIN RESOURCES INC |
| 0.01% | <0.01% | #162 | $61.3M | 1.2M | $6.5M | 182,535 | +987,707+541.11% | Add |
| BNP Paribas Asset Management Holding S.A. |
| 0.06% | — | #88 | $60.7M | 1.2M | $0 | 0 | +1.2M | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #277 | $59.4M | 1.1M | $46.8M | 1.3M | -189,337-14.30% | Reduce |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #185 | $57.5M | 1.1M | $36.6M | 1.0M | +60,822+5.87% | Add |
| T. Rowe Price Investment Management, Inc. |
| 0.04% | 0.02% | #110 | $57.2M | 1.1M | $31.6M | 894,276 | +196,671+21.99% | Add |
| TWO SIGMA INVESTMENTS, LP |
| 0.04% | 0.02% | #107 | $54.4M | 1.0M | $27.6M | 780,683 | +257,628+33.00% | Add |
| Soleus Capital Management, L.P. |
| 1.86% | 2.82% | #15 | $53.9M | 1.0M | $69.7M | 2.0M | -941,612-47.78% | Reduce |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.03% | 0.02% | #128 | $51.5M | 983,822 | $33.9M | 958,016 | +25,806+2.69% | Add |
| MARSHALL WACE, LLP |
| 0.04% | 0.04% | #105 | $50.8M | 969,954 | $35.3M | 999,322 | -29,368-2.94% | Reduce |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC |
| 0.88% | — | #26 | $49.8M | 950,234 | $0 | 0 | +950,234 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #267 | $48.1M | 918,303 | $42.8M | 1.2M | -292,548-24.16% | Reduce |
| VICTORY CAPITAL MANAGEMENT INC |
| 0.03% | 0.01% | #124 | $48.0M | 916,709 | $10.9M | 308,929 | +607,780+196.74% | Add |
| Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #103 | $44.0M | 838,026 | $30.2M | 942,184 | -104,158-11.05% | Reduce |
| Artisan Partners Limited Partnership |
| 0.07% | 0.06% | #83 | $43.5M | 831,006 | $39.3M | 1.1M | -280,735-25.25% | Reduce |
| PANAGORA ASSET MANAGEMENT INC |
| 0.12% | 0.12% | #64 | $40.1M | 765,543 | $33.0M | 932,942 | -167,399-17.94% | Reduce |
| Frazier Life Sciences Management, L.P. |
| 0.8% | 0.64% | #28 | $36.7M | 700,647 | $24.8M | 700,647 | 00.00% | Unchanged |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.09% | 0.07% | #71 | $35.5M | 677,405 | $24.0M | 677,405 | 00.00% | Unchanged |
| FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.32% | — | #43 | $34.6M | 659,562 | $0 | 0 | +659,562 | New Buy |
