| Stonepine Capital Management, LLC |
| 65.32% | 0.3% | #1 | $427.4M | 102.0M | $738,977 | 51.0M | +51.0M+100.00% | Add |
| HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #3 | $253,727 | 62,188 | $264,513 | 61,372 | +816+1.33% | Add |
| Regal Partners Ltd |
| 0.01% | 0.01% | #2 | $168,178 | 40,138 | $172,593 | 40,138 | 00.00% | Unchanged |
| PNC FINANCIAL SERVICES GROUP, INC. |
| <0.01% | <0.01% | #4 | $83,800 | 20,000 | $68,800 | 16,000 | +4,000+25.00% | Add |
| UBS Group AG |
| <0.01% | <0.01% | #6 | $6,314 | 1,507 | $12,900 | 3,000 | -1,493-49.77% | Reduce |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #5 | $5,489 | 1,310 | $0 | 0 | +1,310 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #7 | $817 | 195 | $519 | 121 | +74+61.16% | Add |
