| 5AM Venture Management, LLC |
| 2.33% | 1.65% | #1 | $6.7M | 9.7M | $6.0M | 9.7M | 00.00% | Unchanged |
| Versant Venture Management, LLC |
| 0.86% | 0.87% | #2 | $1.4M | 2.0M | $1.2M | 2.0M | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 0.01% | 0.01% | #5 | $1.1M | 1.6M | $968,144 | 1.6M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #12 | $529,370 | 763,882 | $470,141 | 764,457 | -575-0.08% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.06% | 0.07% | #3 | $470,701 | 678,928 | $417,269 | 678,928 | 00.00% | Unchanged |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.04% | 0.04% | #4 | $161,605 | 233,095 | $143,260 | 233,095 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #19 | $161,452 | 232,874 | $175,855 | 286,131 | -53,257-18.61% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #14 | $151,232 | 218,055 | $170,447 | 277,256 | -59,201-21.35% | Reduce |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #8 | $137,637 | 198,524 | $158,690 | 258,200 | -59,676-23.11% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #13 | $85,969 | 124,000 | $60,784 | 98,900 | +25,100+25.38% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #10 | $72,231 | 104,229 | $64,101 | 104,229 | 00.00% | Unchanged |
| STATE STREET CORP |
| <0.01% | <0.01% | #21 | $51,186 | 73,830 | $46,295 | 75,326 | -1,496-1.99% | Reduce |
| UBS Group AG |
| <0.01% | <0.01% | #15 | $51,143 | 73,800 | $28,143 | 45,762 | +28,038+61.27% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #16 | $39,052 | 56,327 | $12,379 | 20,142 | +36,185+179.65% | Add |
| Qube Research & Technologies Ltd |
| <0.01% | — | #9 | $29,869 | 43,082 | $0 | 0 | +43,082 | New Buy |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #11 | $18,702 | 26,976 | $1,413 | 2,300 | +24,676+1,072.87% | Add |
| XTX Topco Ltd |
| <0.01% | <0.01% | #6 | $14,554 | 20,993 | $25,149 | 40,919 | -19,926-48.70% | Reduce |
| Engineers Gate Manager LP |
| <0.01% | <0.01% | #7 | $14,001 | 20,194 | $12,411 | 20,194 | 00.00% | Unchanged |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #17 | $3,182 | 4,589 | $4,428 | 7,205 | -2,616-36.31% | Reduce |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #22 | $3,158 | 4,557 | $2,803 | 4,557 | 00.00% | Unchanged |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #18 | $2,125 | 3,065 | $0 | 0 | +3,065 | New Buy |
| MORGAN STANLEY |
| <0.01% | <0.01% | #33 | $1,711 | 2,469 | $19,461 | 4,952 | -2,483-50.14% | Reduce |
| BARCLAYS PLC |
| <0.01% | <0.01% | #34 | $455 | 655 | $11,117 | 18,089 | -17,434-96.38% | Reduce |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #25 | $413 | 600 | $364 | 600 | 00.00% | Unchanged |
| NATIONAL BANK OF CANADA /FI/ |
| <0.01% | <0.01% | #27 | $275 | 400 | $242 | 400 | 00.00% | Unchanged |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #41 | $44 | 66 | $39 | 66 | 00.00% | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) |
| <0.01% | <0.01% | #35 | $36 | 52 | $32 | 52 | 00.00% | Unchanged |
| TD Waterhouse Canada Inc. |
| <0.01% | <0.01% | #31 | $35 | 52 | $51 | 79 | -27-34.18% | Reduce |
| Federation des caisses Desjardins du Quebec |
| <0.01% | <0.01% | #30 | $35 | 51 | $31 | 51 | 00.00% | Unchanged |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #36 | $27 | 39 | $24 | 39 | 00.00% | Unchanged |
| Optiver Holding B.V. |
| <0.01% | <0.01% | #40 | $14 | 20 | $12 | 20 | 00.00% | Unchanged |
| CoreCap Advisors, LLC |
| <0.01% | <0.01% | #28 | $6 | 8 | $5 | 8 | 00.00% | Unchanged |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | — | #41 | $5 | 8 | $0 | 0 | +8 | New Buy |
| GILPIN WEALTH MANAGEMENT, LLC |
| <0.01% | — | #20 | $3 | 4 | $0 | 0 | +4 | New Buy |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #39 | $2 | 2 | $0 | 0 | +2 | New Buy |
| Plante Moran Financial Advisors, LLC |
| <0.01% | <0.01% | #31 | $2 | 3 | $2 | 3 | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | — | #43 | $1 | 1 | $0 | 0 | +1 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | — | #43 | $1 | 1 | $0 | 0 | +1 | New Buy |
| HARBOUR INVESTMENTS, INC. |
| <0.01% | <0.01% | #38 | $1 | 1 | $1 | 1 | 00.00% | Unchanged |
| IFP Advisors, Inc |
| <0.01% | <0.01% | #37 | $1 | 1 | $1 | 2 | -1-50.00% | Reduce |
| NFSG Corp |
| <0.01% | <0.01% | #29 | $1 | 1 | $1 | 1 | 00.00% | Unchanged |
| Leo H. Evart, Inc. |
| <0.01% | <0.01% | #23 | $1 | 1 | $1 | 1 | 00.00% | Unchanged |
| PFS Partners, LLC |
| <0.01% | <0.01% | #26 | $1 | 1 | $1 | 1 | 00.00% | Unchanged |
| MCGUIRE CAPITAL ADVISORS INC |
| <0.01% | <0.01% | #24 | $1 | 2 | $1 | 2 | 00.00% | Unchanged |
