| Samsara BioCapital, LLC |
| 0.92% | 1.15% | #1 | $11.2M | 298,496 | $11.8M | 298,496 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #10 | $10.2M | 269,874 | $8.2M | 206,288 | +63,586+30.82% | Add |
| FMR LLC |
| <0.01% | <0.01% | #19 | $9.8M | 260,391 | $10.3M | 260,391 | 00.00% | Unchanged |
| Siren, L.L.C. |
| 0.12% | 0.18% | #5 | $6.1M | 163,000 | $6.5M | 163,000 | 00.00% | Unchanged |
| BAKER BROS. ADVISORS LP |
| 0.03% | 0.03% | #7 | $5.6M | 148,314 | $5.9M | 148,314 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #26 | $3.6M | 94,463 | $4.3M | 108,922 | -14,459-13.27% | Reduce |
| Trails Edge Capital Partners, LP |
| 0.51% | 1.27% | #2 | $3.2M | 85,192 | $5.5M | 139,578 | -54,386-38.96% | Reduce |
| Aisling Capital Management LP |
| 0.4% | — | #3 | $1.9M | 50,000 | $0 | 0 | +50,000 | New Buy |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #14 | $1.5M | 39,560 | $531,007 | 13,389 | +26,171+195.47% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #27 | $1.2M | 32,470 | $1.3M | 32,886 | -416-1.26% | Reduce |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #15 | $657,143 | 17,454 | $0 | 0 | +17,454 | New Buy |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #24 | $611,398 | 16,239 | $639,557 | 16,126 | +113+0.70% | Add |
| BlackRock, Inc. |
| <0.01% | <0.01% | #40 | $554,622 | 14,731 | $499,795 | 12,602 | +2,129+16.89% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | — | #30 | $515,918 | 13,703 | $0 | 0 | +13,703 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #37 | $461,815 | 12,266 | $423,014 | 10,666 | +1,600+15.00% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #22 | $432,448 | 11,486 | $0 | 0 | +11,486 | New Buy |
| Verdad Advisers, LP |
| 0.32% | — | #4 | $338,699 | 8,996 | $0 | 0 | +8,996 | New Buy |
| Integrated Quantitative Investments LLC |
| 0.05% | — | #6 | $309,106 | 8,210 | $0 | 0 | +8,210 | New Buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | — | #34 | $302,066 | 8,023 | $0 | 0 | +8,023 | New Buy |
| Quadrature Capital Ltd |
| <0.01% | — | #11 | $237,383 | 6,305 | $0 | 0 | +6,305 | New Buy |
| Trexquant Investment LP |
| <0.01% | — | #13 | $234,936 | 6,240 | $0 | 0 | +6,240 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #32 | $230,531 | 6,123 | $715,942 | 18,052 | -11,929-66.08% | Reduce |
| Pathstone Holdings, LLC |
| <0.01% | <0.01% | #17 | $228,664 | 6,073 | $240,872 | 6,073 | 00.00% | Unchanged |
| Point72 Asset Management, L.P. |
| <0.01% | — | #23 | $223,905 | 5,947 | $0 | 0 | +5,947 | New Buy |
| HRT FINANCIAL LP |
| <0.01% | — | #20 | $223,001 | 5,923 | $0 | 0 | +5,923 | New Buy |
| CITADEL ADVISORS LLC |
| <0.01% | — | #33 | $222,361 | 5,906 | $0 | 0 | +5,906 | New Buy |
| China Universal Asset Management Co., Ltd. |
| 0.01% | — | #8 | $94,125 | 2,500 | $0 | 0 | +2,500 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #38 | $81,889 | 2,175 | $223,524 | 5,636 | -3,461-61.41% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #31 | $67,845 | 1,802 | $357 | 9 | +1,793+19,922.22% | Add |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #35 | $48,004 | 1,275 | $50,567 | 1,275 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #29 | $38,402 | 1,020 | $44,379 | 1,119 | -99-8.85% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #43 | $37,989 | 1,009 | $17,419 | 746 | +263+35.25% | Add |
| VALLEY NATIONAL ADVISERS INC |
| <0.01% | — | #9 | $36,897 | 980 | $0 | 0 | +980 | New Buy |
| Farther Finance Advisors, LLC |
| <0.01% | <0.01% | #25 | $10,655 | 283 | $11,470 | 283 | 00.00% | Unchanged |
| Strengthening Families & Communities, LLC |
| <0.01% | <0.01% | #12 | $6,513 | 173 | $6,861 | 173 | 00.00% | Unchanged |
| State of Wyoming |
| <0.01% | — | #18 | $5,535 | 147 | $0 | 0 | +147 | New Buy |
| Truvestments Capital LLC |
| <0.01% | — | #16 | $5,384 | 143 | $0 | 0 | +143 | New Buy |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #41 | $4,217 | 112 | $4,000 | 112 | 00.00% | Unchanged |
| Activest Wealth Management |
| <0.01% | <0.01% | #21 | $1,883 | 50 | $1,983 | 50 | 00.00% | Unchanged |
| CoreCap Advisors, LLC |
| <0.01% | <0.01% | #28 | $1,694 | 45 | $1,785 | 45 | 00.00% | Unchanged |
| Parallel Advisors, LLC |
| <0.01% | <0.01% | #36 | $1,431 | 38 | $1,507 | 38 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #44 | $75 | 2 | $79 | 2 | 00.00% | Unchanged |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #39 | $75 | 2 | $0 | 0 | +2 | New Buy |
| Strategic Wealth Partners, Ltd. |
| <0.01% | <0.01% | #42 | $38 | 1 | $40 | 1 | 00.00% | Unchanged |
