| FMR LLC |
| 0.07% | 0.06% | #80 | $1.64B | 4.4M | $1.13B | 4.4M | +44,210+1.01% | Add |
| BlackRock, Inc. |
| 0.02% | 0.02% | #133 | $1.55B | 4.2M | $1.02B | 3.9M | +240,976+6.12% | Add |
| Avoro Capital Advisors LLC |
| 9.64% | 7.34% | #4 | $1.07B | 2.9M | $746.3M | 2.9M | 00.00% | Unchanged |
| VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.02% | #123 | $585.3M | 1.6M | $376.3M | 1.5M | +118,178+8.11% | Add |
| STATE STREET CORP |
| 0.01% | 0.01% | #154 | $502.2M | 1.4M | $339.5M | 1.3M | +36,724+2.79% | Add |
| VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #186 | $461.1M | 1.2M | $301.0M | 1.2M | +75,243+6.46% | Add |
| Soleus Capital Management, L.P. |
| 12.03% | 12.06% | #2 | $349.1M | 939,254 | $297.9M | 1.2M | -213,833-18.54% | Reduce |
| Capital World Investors |
| 0.03% | 0.03% | #113 | $289.1M | 777,843 | $213.0M | 824,720 | -46,877-5.68% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #159 | $259.8M | 698,993 | $166.4M | 643,975 | +55,018+8.54% | Add |
| PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.03% | 0.01% | #126 | $255.5M | 687,400 | $125.3M | 485,074 | +202,326+41.71% | Add |
| Hood River Capital Management LLC |
| 1.79% | 1.61% | #13 | $246.6M | 663,375 | $160.1M | 619,586 | +43,789+7.07% | Add |
| Redmile Group, LLC |
| 15.77% | 11.52% | #1 | $234.9M | 632,005 | $174.0M | 673,505 | -41,500-6.16% | Reduce |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.64% | 0.35% | #24 | $211.9M | 570,153 | $105.2M | 407,178 | +162,975+40.03% | Add |
| Frazier Life Sciences Management, L.P. |
| 3.9% | 3.2% | #9 | $178.9M | 481,307 | $124.3M | 481,307 | 00.00% | Unchanged |
| DIMENSIONAL FUND ADVISORS LP |
| 0.03% | 0.03% | #115 | $176.9M | 476,038 | $121.1M | 468,990 | +7,048+1.50% | Add |
| FIRST TRUST ADVISORS LP |
| 0.07% | 0.06% | #81 | $120.8M | 324,900 | $90.5M | 350,521 | -25,621-7.31% | Reduce |
| Invesco Ltd. |
| 0.01% | 0.01% | #194 | $120.7M | 324,755 | $64.9M | 251,373 | +73,382+29.19% | Add |
| GOLDMAN SACHS GROUP INC |
| 0.01% | 0.01% | #190 | $111.1M | 298,841 | $55.5M | 214,949 | +83,892+39.03% | Add |
| NORTHERN TRUST CORP |
| 0.01% | 0.01% | #171 | $105.5M | 283,784 | $65.2M | 252,463 | +31,321+12.41% | Add |
| FRANKLIN RESOURCES INC |
| 0.02% | 0.01% | #137 | $97.3M | 261,917 | $46.3M | 179,265 | +82,652+46.11% | Add |
| NORGES BANK |
| 0.01% | 0.01% | #193 | $96.3M | 259,030 | $49.3M | 273,209 | -14,179-5.19% | Reduce |
| Jupiter Topco LLC |
| 0.04% | — | #105 | $95.4M | 256,665 | $0 | 0 | +256,665 | New Buy |
| BANK OF AMERICA CORP /DE/ |
| 0.01% | <0.01% | #227 | $95.3M | 256,431 | $67.3M | 260,647 | -4,216-1.62% | Reduce |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #170 | $94.7M | 254,828 | $62.5M | 241,986 | +12,842+5.31% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #249 | $87.5M | 235,491 | $41.4M | 234,578 | +913+0.39% | Add |
| VESTOR CAPITAL, LLC |
| 4.91% | <0.01% | #8 | $78.2M | 700,914 | $52,000 | 200 | +700,714+350,357.00% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.01% | #151 | $70.4M | 189,528 | $46.3M | 179,161 | +10,367+5.79% | Add |
| PRINCIPAL FINANCIAL GROUP INC |
| 0.03% | 0.02% | #117 | $63.0M | 169,550 | $41.9M | 162,070 | +7,480+4.62% | Add |
| Bank of New York Mellon Corp |
| 0.01% | 0.01% | #185 | $60.8M | 163,610 | $38.6M | 149,307 | +14,303+9.58% | Add |
| UBS Group AG |
| 0.01% | 0.01% | #210 | $60.2M | 162,016 | $41.2M | 159,625 | +2,391+1.50% | Add |
| RAYMOND JAMES FINANCIAL INC |
| 0.02% | 0.01% | #147 | $59.0M | 158,675 | $39.5M | 156,064 | +2,611+1.67% | Add |
| Woodline Partners LP |
| 0.17% | 0.15% | #53 | $56.0M | 150,616 | $38.9M | 150,616 | 00.00% | Unchanged |
| Nuveen, LLC |
| 0.01% | 0.01% | #166 | $54.5M | 146,520 | $37.0M | 143,368 | +3,152+2.20% | Add |
| Caption Management, LLC |
| 0.23% | 0.29% | #46 | $48.5M | 130,600 | $49.1M | 190,000 | -59,400-31.26% | Reduce |
| BRAIDWELL LP |
| 1.77% | 1.57% | #14 | $47.9M | 128,975 | $47.1M | 182,425 | -53,450-29.30% | Reduce |
| VOYA INVESTMENT MANAGEMENT LLC |
| 0.04% | 0.03% | #104 | $46.3M | 124,442 | $28.0M | 108,397 | +16,045+14.80% | Add |
| TimesSquare Capital Management, LLC |
| 0.61% | 0.49% | #27 | $41.5M | 111,545 | $29.0M | 112,342 | -797-0.71% | Reduce |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #271 | $40.8M | 109,799 | $42.6M | 164,842 | -55,043-33.39% | Reduce |
| Pictet Asset Management Holding SA |
| 0.04% | 0.03% | #108 | $40.1M | 107,798 | $28.6M | 110,665 | -2,867-2.59% | Reduce |
| PUBLIC SECTOR PENSION INVESTMENT BOARD |
| 0.1% | 0.07% | #71 | $39.2M | 105,515 | $23.8M | 92,286 | +13,229+14.33% | Add |
| 1832 Asset Management L.P. |
| 0.02% | 0.01% | #139 | $36.9M | 99,300 | $11.0M | 42,600 | +56,700+133.10% | Add |
| WESTFIELD CAPITAL MANAGEMENT CO LP |
| 0.12% | — | #62 | $36.7M | 98,707 | $0 | 0 | +98,707 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| 0.02% | 0.01% | #145 | $34.3M | 92,234 | $24.0M | 93,031 | -797-0.86% | Reduce |
| Handelsbanken Fonder AB |
| 0.1% | 0.08% | #72 | $33.6M | 90,407 | $23.6M | 91,400 | -993-1.09% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #303 | $33.5M | 87,342 | $24.5M | 99,105 | -11,763-11.87% | Reduce |
| Nantahala Capital Management, LLC |
| 1.05% | — | #18 | $31.6M | 85,000 | $0 | 0 | +85,000 | New Buy |
| ORBIMED ADVISORS LLC |
| 0.58% | 0.35% | #30 | $30.9M | 83,200 | $17.8M | 69,100 | +14,100+20.41% | Add |
| S SQUARED TECHNOLOGY, LLC |
| 8.94% | 8.43% | #5 | $28.8M | 77,545 | $22.3M | 86,215 | -8,670-10.06% | Reduce |
| Bellevue Group AG |
| 0.61% | 2.96% | #29 | $28.8M | 77,530 | $124.5M | 481,785 | -404,255-83.91% | Reduce |
| Biondo Investment Advisors, LLC |
| 3.23% | 2.39% | #10 | $26.4M | 70,945 | $18.6M | 72,045 | -1,100-1.53% | Reduce |
