| Merck & Co., Inc. |
| 0.71% | — | #1 | $3.8M | 1.2M | $0 | 0 | +1.2M | New Buy |
| Ikarian Capital, LLC |
| 0.02% | 0.02% | #2 | $231,564 | 74,698 | $277,876 | 74,698 | 00.00% | Unchanged |
| Rathbones Group PLC |
| <0.01% | <0.01% | #10 | $141,741 | 45,723 | $170,089 | 45,723 | 00.00% | Unchanged |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #15 | $113,410 | 36,584 | $66,116 | 17,773 | +18,811+105.84% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #12 | $104,780 | 33,800 | $145,917 | 39,225 | -5,425-13.83% | Reduce |
| Annis Gardner Whiting Capital Advisors, LLC |
| 0.01% | 0.02% | #3 | $93,000 | 30,000 | $111,600 | 30,000 | 00.00% | Unchanged |
| J. Safra Sarasin Holding AG |
| <0.01% | — | #6 | $70,999 | 22,896 | $0 | 0 | +22,896 | New Buy |
| RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #13 | $67,723 | 21,849 | $80,564 | 21,659 | +190+0.88% | Add |
| JANE STREET GROUP, LLC |
| <0.01% | — | #17 | $63,801 | 20,581 | $0 | 0 | +20,581 | New Buy |
| BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #8 | $57,121 | 18,426 | $68,545 | 18,426 | 00.00% | Unchanged |
| Stonepine Capital Management, LLC |
| 0.01% | 0.03% | #5 | $54,442 | 17,562 | $73,332 | 19,713 | -2,151-10.91% | Reduce |
| SmartHarvest Portfolios, LLC |
| 0.01% | 0.02% | #4 | $41,726 | 13,460 | $51,366 | 13,808 | -348-2.52% | Reduce |
| XTX Topco Ltd |
| <0.01% | <0.01% | #11 | $39,987 | 12,899 | $82,037 | 22,053 | -9,154-41.51% | Reduce |
| WESBANCO BANK INC |
| <0.01% | <0.01% | #7 | $31,000 | 10,000 | $37,200 | 10,000 | 00.00% | Unchanged |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | <0.01% | #14 | $24,800 | 8,000 | $29,760 | 8,000 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | — | #19 | $19,453 | 6,275 | $0 | 0 | +6,275 | New Buy |
| GAMMA Investing LLC |
| <0.01% | <0.01% | #9 | $14,297 | 4,612 | $19,337 | 5,198 | -586-11.27% | Reduce |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #16 | $1,990 | 642 | $0 | 0 | +642 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #18 | $192 | 62 | $231 | 62 | 00.00% | Unchanged |
