| Woodline Partners LP |
| 0.02% | 0.02% | #4 | $5.5M | 3.7M | $5.9M | 3.7M | +578+0.02% | Add |
| Stonepine Capital Management, LLC |
| 0.2% | 0.55% | #1 | $1.3M | 862,996 | $1.4M | 850,000 | +12,996+1.53% | Add |
| Maven Securities LTD |
| 0.02% | 0.04% | #3 | $1.2M | 809,317 | $1.9M | 1.2M | -366,218-31.15% | Reduce |
| BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #5 | $870,894 | 580,596 | $941,522 | 584,796 | -4,200-0.72% | Reduce |
| Opaleye Management Inc. |
| 0.05% | — | #2 | $562,806 | 375,204 | $0 | 0 | +375,204 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #13 | $82,514 | 55,009 | $96,214 | 59,760 | -4,751-7.95% | Reduce |
| XTX Topco Ltd |
| <0.01% | <0.01% | #6 | $56,654 | 37,769 | $60,620 | 37,652 | +117+0.31% | Add |
| CHOREO, LLC |
| <0.01% | — | #7 | $49,883 | 33,255 | $0 | 0 | +33,255 | New Buy |
| Quantinno Capital Management LP |
| <0.01% | — | #8 | $49,882 | 33,255 | $0 | 0 | +33,255 | New Buy |
| Cerity Partners LLC |
| <0.01% | <0.01% | #12 | $19,218 | 12,812 | $20,627 | 12,812 | 00.00% | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #16 | $18,135 | 12,090 | $19,464 | 12,090 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #11 | $16,800 | 11,200 | $0 | 0 | +11,200 | New Buy |
| JANE STREET GROUP, LLC |
| <0.01% | — | #15 | $15,453 | 10,302 | $0 | 0 | +10,302 | New Buy |
| Steward Partners Investment Advisory, LLC |
| <0.01% | — | #9 | $9,000 | 6,000 | $0 | 0 | +6,000 | New Buy |
| EFG International AG |
| <0.01% | <0.01% | #10 | $1,385 | 923 | $1,486 | 923 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #18 | $228 | 152 | $244 | 152 | 00.00% | Unchanged |
| Continuum Advisory, LLC |
| <0.01% | — | #14 | $75 | 50 | $0 | 0 | +50 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #19 | $15 | 10 | $0 | 0 | +10 | New Buy |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #17 | $4 | 3 | $0 | 0 | +3 | New Buy |
