| Flagship Pioneering, LLC |
| 0.59% | 0.88% | #2 | $9.1M | 1.2M | $10.3M | 1.2M | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #14 | $2.3M | 287,776 | $2.6M | 294,143 | -6,367-2.16% | Reduce |
| MARSHALL WACE, LLP |
| <0.01% | <0.01% | #6 | $1.4M | 172,245 | $1.2M | 139,539 | +32,706+23.44% | Add |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #11 | $1.1M | 133,228 | $2.0M | 226,939 | -93,711-41.29% | Reduce |
| Vontobel Holding Ltd. |
| <0.01% | <0.01% | #4 | $970,273 | 122,975 | $1.2M | 138,468 | -15,493-11.19% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #21 | $875,790 | 111,000 | $904,970 | 102,026 | +8,974+8.80% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #16 | $631,301 | 79,974 | $664,108 | 74,835 | +5,139+6.87% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #13 | $426,092 | 54,004 | $527,765 | 59,500 | -5,496-9.24% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #10 | $384,125 | 48,685 | $351,633 | 39,643 | +9,042+22.81% | Add |
| STATE STREET CORP |
| <0.01% | <0.01% | #24 | $267,479 | 33,901 | $300,702 | 33,901 | 00.00% | Unchanged |
| Lion Point Capital, LP |
| 1.19% | 1.67% | #1 | $249,087 | 31,570 | $280,026 | 31,570 | 00.00% | Unchanged |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #17 | $244,977 | 31,049 | $280,558 | 31,630 | -581-1.84% | Reduce |
| AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #9 | $223,390 | 28,313 | $552,743 | 62,316 | -34,003-54.57% | Reduce |
| XTX Topco Ltd |
| <0.01% | — | #5 | $163,575 | 20,732 | $0 | 0 | +20,732 | New Buy |
| GOLDMAN SACHS GROUP INC |
| <0.01% | — | #22 | $120,157 | 15,229 | $0 | 0 | +15,229 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #20 | $116,496 | 14,765 | $130,966 | 14,765 | 00.00% | Unchanged |
| Invesco Ltd. |
| <0.01% | <0.01% | #23 | $102,365 | 12,974 | $129,032 | 14,547 | -1,573-10.81% | Reduce |
| MORGAN STANLEY |
| <0.01% | <0.01% | #26 | $95,769 | 12,138 | $352,746 | 18,334 | -6,196-33.80% | Reduce |
| SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #19 | $36,278 | 4,598 | $27,230 | 3,070 | +1,528+49.77% | Add |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #7 | $32,996 | 4,182 | $30,885 | 3,482 | +700+20.10% | Add |
| Integrated Wealth Concepts LLC |
| <0.01% | — | #8 | $31,560 | 4,000 | $0 | 0 | +4,000 | New Buy |
| GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #15 | $29,303 | 3,714 | $7,309 | 824 | +2,890+350.73% | Add |
| JPMORGAN CHASE & CO |
| <0.01% | — | #27 | $28,325 | 3,636 | $0 | 0 | +3,636 | New Buy |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #25 | $15,583 | 1,975 | $17,518 | 1,975 | 00.00% | Unchanged |
| FMR LLC |
| <0.01% | <0.01% | #30 | $12,056 | 1,528 | $15,540 | 1,752 | -224-12.79% | Reduce |
| Rachor Investment Advisory Services, LLC |
| 0.01% | 0.01% | #3 | $11,654 | 1,477 | $13,101 | 1,477 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #31 | $3,818 | 484 | $62,357 | 7,030 | -6,546-93.12% | Reduce |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #12 | $2,493 | 316 | $7,043 | 794 | -478-60.20% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #29 | $1,665 | 211 | $1,872 | 211 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | <0.01% | #33 | $1,318 | 167 | $57,717 | 6,507 | -6,340-97.43% | Reduce |
| Continuum Advisory, LLC |
| <0.01% | — | #18 | $371 | 47 | $0 | 0 | +47 | New Buy |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #32 | $292 | 37 | $0 | 0 | +37 | New Buy |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #36 | $79 | 10 | $89 | 10 | 00.00% | Unchanged |
| OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #35 | $63 | 8 | $70 | 8 | 00.00% | Unchanged |
| Larson Financial Group LLC |
| <0.01% | — | #28 | $39 | 5 | $0 | 0 | +5 | New Buy |
| WHITTIER TRUST CO OF NEVADA INC |
| <0.01% | — | #34 | $8 | 1 | $0 | 0 | +1 | New Buy |
