| ARCH Venture Management, LLC |
| 0.61% | — | #1 | $6.7M | 2.7M | $0 | 0 | +2.7M | New Buy |
| FMR LLC |
| <0.01% | <0.01% | #23 | $6.5M | 2.6M | $3.0M | 2.7M | -114,400-4.24% | Reduce |
| TANG CAPITAL MANAGEMENT LLC |
| 0.29% | — | #2 | $6.4M | 2.6M | $0 | 0 | +2.6M | New Buy |
| ADAR1 Capital Management, LLC |
| 0.23% | — | #3 | $4.9M | 2.0M | $0 | 0 | +2.0M | New Buy |
| Cormorant Asset Management, LP |
| 0.13% | — | #5 | $2.5M | 1.0M | $0 | 0 | +1.0M | New Buy |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #28 | $1.5M | 614,923 | $656,911 | 597,192 | +17,731+2.97% | Add |
| WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #24 | $1.4M | 556,233 | $611,856 | 556,233 | 00.00% | Unchanged |
| MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #21 | $1.2M | 478,639 | $109,862 | 99,875 | +378,764+379.24% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #16 | $1.2M | 471,570 | $438,900 | 399,000 | +72,570+18.19% | Add |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #15 | $750,000 | 300,000 | $330,000 | 300,000 | 00.00% | Unchanged |
| Affinity Asset Advisors, LLC |
| 0.03% | — | #8 | $625,000 | 250,000 | $0 | 0 | +250,000 | New Buy |
| RBF Capital, LLC |
| 0.02% | 0.01% | #9 | $500,000 | 200,000 | $220,000 | 200,000 | 00.00% | Unchanged |
| Ensign Peak Advisors, Inc |
| <0.01% | <0.01% | #18 | $399,588 | 159,835 | $206,250 | 187,500 | -27,665-14.75% | Reduce |
| Stonepine Capital Management, LLC |
| 0.06% | 0.26% | #7 | $386,488 | 154,595 | $657,450 | 597,682 | -443,087-74.13% | Reduce |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #20 | $366,892 | 146,757 | $12,000 | 12,610 | +134,147+1,063.81% | Add |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #26 | $362,623 | 145,049 | $1.5M | 1.3M | -1.2M-89.19% | Reduce |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #12 | $320,000 | 128,000 | $55,550 | 50,500 | +77,500+153.47% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #30 | $291,839 | 116,736 | $140,333 | 127,576 | -10,840-8.50% | Reduce |
| HRT FINANCIAL LP |
| <0.01% | — | #19 | $290,720 | 116,288 | $0 | 0 | +116,288 | New Buy |
| BlackRock, Inc. |
| <0.01% | <0.01% | #33 | $221,239 | 88,495 | $77,743 | 70,675 | +17,820+25.21% | Add |
| PRELUDE CAPITAL MANAGEMENT, LLC |
| 0.01% | — | #10 | $209,995 | 83,998 | $0 | 0 | +83,998 | New Buy |
| Rangeley Capital, LLC |
| 0.18% | — | #4 | $185,000 | 74,000 | $0 | 0 | +74,000 | New Buy |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | 0.01% | #11 | $180,882 | 72,353 | $107,000 | 96,824 | -24,471-25.27% | Reduce |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #27 | $162,840 | 65,136 | $71,650 | 65,136 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | — | #31 | $160,807 | 64,323 | $0 | 0 | +64,323 | New Buy |
| SUPERSTRING CAPITAL MANAGEMENT LP |
| 0.09% | — | #6 | $138,390 | 55,356 | $0 | 0 | +55,356 | New Buy |
| NORTHERN TRUST CORP |
| <0.01% | — | #32 | $87,060 | 34,824 | $0 | 0 | +34,824 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #17 | $83,403 | 33,361 | $38,138 | 34,671 | -1,310-3.78% | Reduce |
| Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #25 | $50,518 | 20,207 | $19,241 | 17,492 | +2,715+15.52% | Add |
| China Universal Asset Management Co., Ltd. |
| <0.01% | — | #14 | $42,250 | 16,900 | $0 | 0 | +16,900 | New Buy |
| STATE STREET CORP |
| <0.01% | <0.01% | #35 | $39,905 | 15,962 | $17,558 | 15,962 | 00.00% | Unchanged |
| MORGAN STANLEY |
| <0.01% | <0.01% | #34 | $32,500 | 13,000 | $19,066 | 15,501 | -2,501-16.13% | Reduce |
| Caitong International Asset Management Co., Ltd |
| <0.01% | <0.01% | #13 | $26,108 | 10,443 | $3 | 3 | +10,440+348,000.00% | Add |
| Pure Financial Advisors, LLC |
| <0.01% | <0.01% | #22 | $25,250 | 10,100 | $11,110 | 10,100 | 00.00% | Unchanged |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #29 | $870 | 348 | $2,608 | 2,371 | -2,023-85.32% | Reduce |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #37 | $440 | 176 | $196 | 178 | -2-1.12% | Reduce |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #40 | $439 | 179 | $183 | 169 | +10+5.92% | Add |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #38 | $125 | 50 | $0 | 0 | +50 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #41 | $5 | 2 | $2 | 2 | 00.00% | Unchanged |
| Financial Management Professionals, Inc. |
| <0.01% | — | #36 | $5 | 2 | $0 | 0 | +2 | New Buy |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #39 | $5 | 2 | $1 | 1 | +1+100.00% | Add |
