| Stonepine Capital Management, LLC |
| 0.35% | 0.39% | #1 | $2.3M | 1.6M | $981,850 | 663,412 | +961,150+144.88% | Add |
| Alyeska Investment Group, L.P. |
| <0.01% | <0.01% | #4 | $1.3M | 944,319 | $1.4M | 944,319 | 00.00% | Unchanged |
| FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #7 | $1.3M | 914,531 | $1.4M | 914,531 | 00.00% | Unchanged |
| 683 Capital Management, LLC |
| 0.05% | 0.06% | #3 | $1.0M | 724,637 | $1.1M | 724,637 | 00.00% | Unchanged |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #15 | $126,544 | 88,865 | $0 | 0 | +88,865 | New Buy |
| BIOS Capital Management, LP |
| 0.27% | 0.47% | #2 | $114,149 | 80,957 | $248,351 | 167,805 | -86,848-51.76% | Reduce |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #13 | $102,298 | 72,550 | $127,635 | 86,239 | -13,689-15.87% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | — | #12 | $88,908 | 63,055 | $0 | 0 | +63,055 | New Buy |
| OPPENHEIMER & CO INC |
| <0.01% | <0.01% | #6 | $88,889 | 63,042 | $35,569 | 24,033 | +39,009+162.31% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #11 | $62,044 | 43,570 | $0 | 0 | +43,570 | New Buy |
| CAPTRUST FINANCIAL ADVISORS |
| <0.01% | <0.01% | #9 | $46,946 | 33,295 | $49,277 | 33,295 | 00.00% | Unchanged |
| Texas Capital Bank Wealth Management Services Inc |
| <0.01% | <0.01% | #5 | $34,412 | 24,406 | $35,150 | 23,750 | +656+2.76% | Add |
| NORTHERN TRUST CORP |
| <0.01% | <0.01% | #14 | $30,645 | 21,734 | $30,251 | 20,440 | +1,294+6.33% | Add |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #10 | $17,061 | 12,100 | $0 | 0 | +12,100 | New Buy |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #8 | $5,271 | 3,738 | $1,872 | 1,265 | +2,473+195.49% | Add |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | <0.01% | #16 | $3,927 | 2,785 | $4,122 | 2,785 | 00.00% | Unchanged |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #17 | $1,044 | 768 | $1,083 | 768 | 00.00% | Unchanged |
| BlackRock, Inc. |
| <0.01% | <0.01% | #20 | $118 | 84 | $124 | 84 | 00.00% | Unchanged |
| Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #18 | $117 | 83 | $123 | 83 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #19 | $39 | 28 | $0 | 0 | +28 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #21 | $1 | 1 | $710 | 480 | -479-99.79% | Reduce |
