| Opaleye Management Inc. |
| 1.89% | 1.85% | #3 | $20.9M | 2.9M | $14.1M | 2.6M | +333,517+13.02% | Add |
| Solas Capital Management, LLC |
| 7.45% | 6.08% | #1 | $13.9M | 1.9M | $10.6M | 1.9M | 00.00% | Unchanged |
| AWM Investment Company, Inc. |
| 1.05% | 1.02% | #4 | $12.1M | 1.7M | $9.2M | 1.7M | 00.00% | Unchanged |
| Cable Car Capital, LP |
| 2.47% | 2.52% | #2 | $7.6M | 1.4M | $7.6M | 1.4M | 00.00% | Unchanged |
| Ikarian Capital, LLC |
| 0.64% | 0.47% | #5 | $6.0M | 836,259 | $5.8M | 1.1M | -220,000-20.83% | Reduce |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.51% | 0.49% | #6 | $3.9M | 545,816 | $3.1M | 567,616 | -21,800-3.84% | Reduce |
| Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #12 | $2.6M | 365,000 | $2.0M | 365,000 | 00.00% | Unchanged |
| Aristides Capital LLC |
| 0.31% | 0.26% | #7 | $1.6M | 218,510 | $1.2M | 218,510 | 00.00% | Unchanged |
| BOOTHBAY FUND MANAGEMENT, LLC |
| 0.02% | 0.02% | #10 | $1.4M | 189,148 | $1.4M | 256,393 | -67,245-26.23% | Reduce |
| CANTOR FITZGERALD, L. P. |
| 0.01% | 0.02% | #11 | $786,388 | 108,918 | $1.0M | 188,631 | -79,713-42.26% | Reduce |
| CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #16 | $704,282 | 97,546 | $491,844 | 89,589 | +7,957+8.88% | Add |
| VILLERE ST DENIS J & CO LLC |
| 0.06% | 0.04% | #9 | $513,760 | 71,158 | $390,657 | 71,158 | 00.00% | Unchanged |
| TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #14 | $444,723 | 61,596 | $338,162 | 61,596 | 00.00% | Unchanged |
| ACT CAPITAL MANAGEMENT, LLC |
| 0.24% | 0.22% | #8 | $371,830 | 51,500 | $282,735 | 51,500 | 00.00% | Unchanged |
| BERKSHIRE ASSET MANAGEMENT LLC/PA |
| 0.01% | — | #13 | $143,129 | 19,824 | $0 | 0 | +19,824 | New Buy |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #15 | $135,967 | 18,832 | $87,214 | 15,886 | +2,946+18.54% | Add |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #21 | $86,582 | 11,992 | $65,836 | 11,992 | 00.00% | Unchanged |
| RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #19 | $72,200 | 10,000 | $54,900 | 10,000 | 00.00% | Unchanged |
| NATIONAL BANK OF CANADA /FI/ |
| <0.01% | <0.01% | #17 | $37,717 | 5,292 | $28,298 | 5,292 | 00.00% | Unchanged |
| UBS Group AG |
| <0.01% | <0.01% | #23 | $10,512 | 1,456 | $2,405 | 438 | +1,018+232.42% | Add |
| Allworth Financial LP |
| <0.01% | <0.01% | #18 | $5,415 | 750 | $4,118 | 750 | 00.00% | Unchanged |
| JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #24 | $1,625 | 250 | $508 | 100 | +150+150.00% | Add |
| MORGAN STANLEY |
| <0.01% | <0.01% | #26 | $1,444 | 200 | $5,468 | 840 | -640-76.19% | Reduce |
| Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #20 | $1,444 | 200 | $1,098 | 200 | 00.00% | Unchanged |
| ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #25 | $1,000 | 122 | $4,000 | 679 | -557-82.03% | Reduce |
| HARBOUR INVESTMENTS, INC. |
| <0.01% | <0.01% | #22 | $336 | 47 | $25 | 4 | +43+1,075.00% | Add |
