| CITADEL ADVISORS LLC |
| 0.01% | <0.01% | #8 | $123.3M | 7.7M | $178,377 | 19,886 | +7.7M+38,649.81% | Add |
| ADAR1 Capital Management, LLC |
| 0.68% | 0.01% | #3 | $14.8M | 926,352 | $184,199 | 20,535 | +905,817+4,411.09% | Add |
| FMR LLC |
| <0.01% | <0.01% | #16 | $12.7M | 794,720 | $7.1M | 793,451 | +1,269+0.16% | Add |
| VIKING GLOBAL INVESTORS LP |
| 0.02% | 0.01% | #7 | $8.4M | 524,347 | $4.7M | 524,347 | 00.00% | Unchanged |
| TPG GP A, LLC |
| 0.12% | 0.09% | #5 | $6.1M | 378,551 | $3.4M | 378,551 | 00.00% | Unchanged |
| Pivotal bioVenture Partners Investment Advisor LLC |
| 1.56% | 0.96% | #2 | $4.8M | 300,579 | $2.7M | 300,579 | 00.00% | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #10 | $3.2M | 199,907 | $1.4M | 156,527 | +43,380+27.71% | Add |
| Nantahala Capital Management, LLC |
| 0.1% | 0.1% | #6 | $3.0M | 188,422 | $2.7M | 300,635 | -112,213-37.33% | Reduce |
| VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $2.8M | 172,497 | $1.0M | 112,040 | +60,457+53.96% | Add |
| Almitas Capital LLC |
| 0.45% | 0.39% | #4 | $1.9M | 120,682 | $1.7M | 191,206 | -70,524-36.88% | Reduce |
| Rangeley Capital, LLC |
| 1.6% | 0.26% | #1 | $1.7M | 104,850 | $270,266 | 30,130 | +74,720+247.99% | Add |
| Mariner, LLC |
| <0.01% | <0.01% | #14 | $809,056 | 50,566 | $453,577 | 50,566 | 00.00% | Unchanged |
| JANE STREET GROUP, LLC |
| <0.01% | — | #21 | $758,768 | 47,423 | $0 | 0 | +47,423 | New Buy |
| GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #25 | $512,865 | 32,047 | $317,821 | 35,425 | -3,378-9.54% | Reduce |
| BlackRock, Inc. |
| <0.01% | <0.01% | #29 | $485,312 | 30,332 | $156,849 | 17,486 | +12,846+73.46% | Add |
| HRT FINANCIAL LP |
| <0.01% | — | #15 | $410,512 | 25,657 | $0 | 0 | +25,657 | New Buy |
| XTX Topco Ltd |
| <0.01% | <0.01% | #9 | $343,952 | 21,497 | $100,697 | 11,226 | +10,271+91.49% | Add |
| VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #22 | $269,120 | 16,820 | $121,517 | 13,547 | +3,273+24.16% | Add |
| TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #18 | $265,904 | 16,619 | $0 | 0 | +16,619 | New Buy |
| STATE STREET CORP |
| <0.01% | — | #30 | $207,936 | 12,996 | $0 | 0 | +12,996 | New Buy |
| Quadrature Capital Ltd |
| <0.01% | — | #12 | $207,920 | 12,995 | $0 | 0 | +12,995 | New Buy |
| DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #24 | $180,480 | 11,280 | $101,182 | 11,280 | 00.00% | Unchanged |
| Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #28 | $23,072 | 1,442 | $12,935 | 1,442 | 00.00% | Unchanged |
| MERCER GLOBAL ADVISORS INC /ADV |
| <0.01% | — | #26 | $20,000 | 1,250 | $0 | 0 | +1,250 | New Buy |
| Hartford Financial Management Inc. |
| <0.01% | <0.01% | #11 | $12,992 | 812 | $7,284 | 812 | 00.00% | Unchanged |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #19 | $8,096 | 506 | $4,700 | 524 | -18-3.44% | Reduce |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #13 | $6,944 | 434 | $0 | 0 | +434 | New Buy |
| UBS Group AG |
| <0.01% | <0.01% | #33 | $2,336 | 146 | $70,989 | 7,914 | -7,768-98.16% | Reduce |
| Truvestments Capital LLC |
| <0.01% | — | #17 | $2,064 | 129 | $0 | 0 | +129 | New Buy |
| MORGAN STANLEY |
| <0.01% | — | #34 | $2,000 | 125 | $0 | 0 | +125 | New Buy |
| BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #31 | $1,920 | 120 | $1,076 | 120 | 00.00% | Unchanged |
| Fortitude Family Office, LLC |
| <0.01% | <0.01% | #20 | $848 | 53 | $475 | 53 | 00.00% | Unchanged |
| WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #35 | $592 | 37 | $332 | 37 | 00.00% | Unchanged |
| EverSource Wealth Advisors, LLC |
| <0.01% | — | #27 | $496 | 31 | $0 | 0 | +31 | New Buy |
| JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #38 | $145 | 9 | $20,076 | 2,497 | -2,488-99.64% | Reduce |
| Allworth Financial LP |
| <0.01% | <0.01% | #32 | $96 | 6 | $54 | 6 | 00.00% | Unchanged |
| BARCLAYS PLC |
| <0.01% | — | #37 | $48 | 3 | $0 | 0 | +3 | New Buy |
| DANSKE BANK A/S |
| <0.01% | <0.01% | #36 | $16 | 1 | $9 | 1 | 00.00% | Unchanged |
