| AASCENDIS PHARMA A/S SPONSORED ADRASND |
| 23.83% | 24.92% | $2.74B | 10.3M | $2.35B | 10.3M | 00.00% | Unchanged |
| PPARABILIS MEDICINES INCPBLS |
| 6.88% | — | $791.9M | 28.9M | $0 | 0 | +28.9M | New Buy |
 RHYTHM PHARMACEUTICALS INCRYTM |
| 6.43% | 6.14% | $740.2M | 6.7M | $579.8M | 6.7M | 00.00% | Unchanged |
 VAXCYTE INCPCVX |
| 5.8% | 7.07% | $667.0M | 11.5M | $666.8M | 11.5M | 00.00% | Unchanged |
| SSIONNA THERAPEUTICS INCSION |
| 3.79% | 4.21% | $435.7M | 9.9M | $397.1M | 9.9M | 00.00% | Unchanged |
| TTYRA BIOSCIENCES INCTYRA |
| 3.39% | 4.95% | $389.6M | 12.2M | $467.2M | 12.2M | 00.00% | Unchanged |
 EDGEWISE THERAPEUTICS INCEWTX |
| 2.96% | 3.48% | $341.0M | 8.4M | $328.5M | 10.4M | -2.0M-19.52% | Reduce |
| NNEWAMSTERDAM PHARMA COMPANYNAMS |
| 2.81% | 3.24% | $323.7M | 9.6M | $305.7M | 9.6M | 00.00% | Unchanged |
| HHEMAB THERAPEUTICS HLDGS INCCOAG |
| 2.49% | — | $286.8M | 7.8M | $0 | 0 | +7.8M | New Buy |
| SSEPTERNA INCSEPN |
| 2.04% | 1.78% | $234.3M | 7.0M | $168.1M | 7.0M | 00.00% | Unchanged |
| BBICARA THERAPEUTICS INCBCAX |
| 1.87% | 1.53% | $215.4M | 7.3M | $144.3M | 7.3M | 00.00% | Unchanged |
 MINERALYS THERAPEUTICS INCMLYS |
| 1.8% | 2.21% | $207.6M | 7.7M | $208.4M | 7.7M | 00.00% | Unchanged |
 GH RESEARCH PLC ORDINARY SHARESGHRS |
| 1.78% | 1.14% | $205.3M | 7.6M | $107.9M | 7.7M | -39,884-0.52% | Reduce |
 DISC MEDICINE INCIRON |
| 1.56% | 1.66% | $179.2M | 2.5M | $156.7M | 2.5M | 00.00% | Unchanged |
| SSPYGLASS PHARMA INCSGP |
| 1.55% | 2.2% | $178.6M | 8.0M | $207.8M | 8.0M | 00.00% | Unchanged |
| AARTIVA BIOTHERAPEUTICS INCARTV |
| 1.51% | 0.67% | $174.2M | 18.0M | $63.5M | 9.9M | +8.1M+82.23% | Add |
 JANUX THERAPEUTICS INCJANX |
| 1.49% | 1.65% | $171.9M | 11.2M | $155.5M | 11.2M | 00.00% | Unchanged |
 TAYSHA GENE THERAPIES INCTSHA |
| 1.39% | 1.12% | $160.4M | 23.6M | $105.3M | 23.6M | 00.00% | Unchanged |
 BIOCRYST PHARMACEUTICALS INCBCRX |
| 1.38% | 1.6% | $158.3M | 15.8M | $150.7M | 15.8M | 00.00% | Unchanged |
 WAVE LIFE SCIENCES LTDWVE |
| 1.36% | 2.07% | $156.7M | 27.0M | $195.6M | 27.0M | 00.00% | Unchanged |
| NNUVALENT INCNUVL |
| 1.34% | 2.75% | $153.9M | 1.2M | $259.6M | 2.5M | -1.3M-50.81% | Reduce |
 ABIVAX SAABVX |
| 1.31% | — | $150.9M | 1.1M | $0 | 0 | +1.1M | New Buy |
| OORUKA THERAPEUTICS INC COMORKA |
| 1.29% | — | $148.0M | 1.6M | $0 | 0 | +1.6M | New Buy |
| CCLIMB BIO INC COMCLYM |
| 1.28% | 0.82% | $147.4M | 11.3M | $77.4M | 11.3M | 00.00% | Unchanged |
 SOLID BIOSCIENCES INCSLDB |
| 1.04% | 0.71% | $120.2M | 12.0M | $67.2M | 9.3M | +2.7M+28.87% | Add |
| ZZAI LAB LIMITED ADS EACH REP 10 ORD SHSZLAB |
| 0.95% | 1.14% | $109.1M | 5.7M | $107.4M | 5.7M | +36,271+0.64% | Add |
| AARS PHARMACEUTICALS INCSPRY |
| 0.76% | 0.92% | $87.0M | 10.9M | $87.2M | 10.9M | 00.00% | Unchanged |
| XXENCOR INCXNCR |
| 0.74% | 0.63% | $84.9M | 5.3M | $59.1M | 4.9M | +377,037+7.70% | Add |
 JADE BIOSCIENCES INCJBIO |
| 0.71% | 0.55% | $81.6M | 3.7M | $51.6M | 3.7M | 00.00% | Unchanged |
| IINTELLIA THERAPEUTICS INCNTLA |
| 0.67% | — | $76.6M | 4.5M | $0 | 0 | +4.5M | New Buy |
| LLB PHARMACEUTICALS INCLBRX |
| 0.62% | 0.58% | $71.7M | 2.2M | $54.5M | 2.2M | 00.00% | Unchanged |
| DDEFINIUM THERAPEUTICS INCDFTX |
| 0.61% | — | $70.6M | 1.5M | $0 | 0 | +1.5M | New Buy |
| AACLARIS THERAPEUTICS INC COMACRS |
| 0.58% | 0.27% | $67.3M | 12.7M | $25.5M | 6.8M | +5.9M+86.99% | Add |
 4D MOLECULAR THERAPEUTICS INFDMT |
| 0.58% | 0.5% | $67.2M | 5.0M | $47.0M | 5.0M | 00.00% | Unchanged |
| SSANA BIOTECHNOLOGY INCSANA |
| 0.57% | — | $65.4M | 18.8M | $0 | 0 | +18.8M | New Buy |
| DDAMORA THERAPEUTICS INCDMRA |
| 0.54% | 0.66% | $62.4M | 2.4M | $62.1M | 2.4M | +392+0.02% | Add |
| MMONOPAR THERAPEUTICS INCMNPR |
| 0.54% | 0.39% | $61.8M | 667,207 | $36.6M | 667,207 | 00.00% | Unchanged |
| AACUMEN PHARMACEUTICALS INCABOS |
| 0.49% | 0.52% | $56.1M | 21.0M | $49.5M | 21.0M | 00.00% | Unchanged |
| GGERON CORPGERN |
| 0.48% | 1.01% | $54.8M | 42.8M | $95.0M | 63.8M | -21.0M-32.87% | Reduce |
 REZOLUTE INCRZLT |
| 0.43% | 0.3% | $49.1M | 9.4M | $28.0M | 9.2M | +265,039+2.89% | Add |
| EEVOMMUNE INCEVMN |
| 0.4% | 0.85% | $46.4M | 3.5M | $80.3M | 3.5M | 00.00% | Unchanged |
| VVOR BIOPHARMA INCVOR |
| 0.38% | 1.02% | $44.2M | 2.4M | $96.4M | 5.4M | -3.0M-55.56% | Reduce |
| CCENTURY THERAPEUTICS INC COMIPSC |
| 0.38% | 0.43% | $43.5M | 17.8M | $40.1M | 17.8M | 00.00% | Unchanged |
| AAKTIS ONCOLOGY INCAKTS |
| 0.37% | 0.28% | $42.4M | 1.3M | $26.9M | 1.5M | -188,679-12.55% | Reduce |
| BBIOAGE LABS INCBIOA |
| 0.36% | 0.31% | $41.0M | 1.7M | $28.9M | 1.7M | +21,000+1.27% | Add |
| CC4 THERAPEUTICS INC COM STKCCCC |
| 0.32% | 0.22% | $37.4M | 8.0M | $21.0M | 8.0M | 00.00% | Unchanged |
| MMIRUM PHARMACEUTICALS INCMIRM |
| 0.32% | 0.31% | $37.3M | 318,554 | $29.4M | 318,554 | 00.00% | Unchanged |
| CCAPRICOR THERAPEUTICS INC COM NEWCAPR |
| 0.32% | 0.49% | $36.3M | 1.5M | $45.8M | 1.5M | 00.00% | Unchanged |
| PPEPGEN INCPEPG |
| 0.31% | 0.38% | $36.1M | 20.1M | $35.5M | 20.1M | 00.00% | Unchanged |
| PPRELUDE THERAPEUTICS INC COMPRLD |
| 0.3% | — | $34.5M | 6.5M | $0 | 0 | +6.5M | New Buy |
