| Ikarian Capital, LLC |
| 0.05% | 0.2% | #2 | $46.1万 | 28.8万股 | $250.7万 | 23.8万股 | +5.0万股+20.98% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | — | #11 | $44.4万 | 27.7万股 | $0 | 0股 | +27.7万股 | 新买入 |
| Sofinnova Investments, Inc. |
| 0.02% | 0.09% | #5 | $35.6万 | 22.3万股 | $237.8万 | 22.3万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #13 | $27.4万 | 17.1万股 | $64.7万 | 6.1万股 | +11.1万股+182.82% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #20 | $25.1万 | 15.7万股 | $0 | 0股 | +15.7万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | — | #16 | $14.1万 | 8.8万股 | $0 | 0股 | +8.8万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | 0.01% | #8 | $13.5万 | 8.5万股 | $74.4万 | 7.0万股 | +1.5万股+21.65% | 加仓 |
| Squadron Capital Management LLC |
| 0.03% | 1.04% | #4 | $10.3万 | 6.4万股 | $283.0万 | 26.5万股 | -20.1万股-75.67% | 减仓 |
| Verdad Advisers, LP |
| 0.09% | 0.52% | #1 | $9.7万 | 6.0万股 | $45.9万 | 4.3万股 | +1.7万股+40.73% | 加仓 |
| PFIZER INC |
| 0.04% | 0.64% | #3 | $7.3万 | 4.4万股 | $153.5万 | 15.3万股 | -10.9万股-71.08% | 减仓 |
| Affinity Asset Advisors, LLC |
| <0.01% | 0.13% | #6 | $6.7万 | 4.2万股 | $258.3万 | 24.2万股 | -20.0万股-82.65% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #24 | $6.0万 | 3.7万股 | $29.7万 | 2.8万股 | +9,555股+34.38% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #14 | $5.8万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | — | #21 | $5.2万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $4.8万 | 3.0万股 | $32.7万 | 3.1万股 | -1,187股-3.82% | 减仓 |
| CARDIFF PARK ADVISORS, LLC |
| <0.01% | 0.02% | #7 | $3.5万 | 2.2万股 | $23.3万 | 2.2万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #17 | $3.0万 | 1.9万股 | $19.9万 | 1.9万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #19 | $2.6万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | — | #18 | $2.0万 | 1.3万股 | $0 | 0股 | +1.3万股 | 新买入 |
| Virtu Financial LLC |
| <0.01% | — | #12 | $1.8万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| DIADEMA PARTNERS LP |
| <0.01% | — | #9 | $1.2万 | 7,742股 | $0 | 0股 | +7,742股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #23 | $9,162 | 5,726股 | $6.0万 | 5,626股 | +100股+1.78% | 加仓 |
| Persistent Asset Partners Ltd |
| <0.01% | — | #10 | $3,170 | 1,981股 | $0 | 0股 | +1,981股 | 新买入 |
| Tower Research Capital LLC (TRC) |
| <0.01% | — | #15 | $2,781 | 1,738股 | $0 | 0股 | +1,738股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #26 | $951 | 594股 | $3,610 | 338股 | +256股+75.74% | 加仓 |
| 西北互惠财富管理NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | — | #27 | $133 | 83股 | $0 | 0股 | +83股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #29 | $107 | 61股 | $587 | 61股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #29 | $106 | 66股 | $0 | 0股 | +66股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #28 | $51 | 32股 | $342 | 32股 | 00.00% | 持仓不变 |
| SBI Securities Co., Ltd. |
| <0.01% | — | #25 | $32 | 20股 | $0 | 0股 | +20股 | 新买入 |
