| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 5.77% | 6.44% | #5 | $11.51亿 | 214.3万股 | $11.21亿 | 214.2万股 | +1,430股+0.07% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 9.14% | 10.38% | #2 | $10.71亿 | 199.4万股 | $10.44亿 | 199.4万股 | 00.00% | 持仓不变 |
| 木星资产管理Jupiter Topco LLC |
| 0.42% | — | #30 | $10.40亿 | 193.6万股 | $0 | 0股 | +193.6万股 | 新买入 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 8.84% | 9.36% | #3 | $9.84亿 | 183.3万股 | $9.52亿 | 181.8万股 | +1.5万股+0.83% | 加仓 |
| 保尔森公司PAULSON & CO. INC. |
| 27.94% | 23.42% | #1 | $7.20亿 | 134.0万股 | $7.29亿 | 139.2万股 | -5.2万股-3.75% | 减仓 |
| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #183 | $6.45亿 | 120.1万股 | $8.17亿 | 156.0万股 | -35.9万股-23.03% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #182 | $4.49亿 | 83.6万股 | $4.33亿 | 82.7万股 | +8,524股+1.03% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.08% | 0.07% | #78 | $4.43亿 | 82.6万股 | $3.64亿 | 69.5万股 | +13.1万股+18.81% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #142 | $4.20亿 | 78.2万股 | $4.40亿 | 84.1万股 | -5.9万股-7.06% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.04% | 0.05% | #104 | $3.69亿 | 68.8万股 | $3.15亿 | 60.3万股 | +8.6万股+14.20% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #195 | $2.83亿 | 52.7万股 | $3.19亿 | 61.0万股 | -8.2万股-13.53% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.01% | #143 | $2.40亿 | 44.7万股 | $1.26亿 | 24.1万股 | +20.6万股+85.74% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.03% | 0.01% | #121 | $2.16亿 | 40.2万股 | $6,165.4万 | 11.8万股 | +28.4万股+241.07% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #173 | $2.01亿 | 37.5万股 | $2.39亿 | 45.6万股 | -8.1万股-17.77% | 减仓 |
| 富达投资FMR LLC |
| 0.01% | 0.01% | #197 | $1.91亿 | 35.6万股 | $2.68亿 | 51.2万股 | -15.6万股-30.39% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.02% | 0.02% | #149 | $1.91亿 | 35.5万股 | $1.25亿 | 23.9万股 | +11.6万股+48.32% | 加仓 |
| 威廉·布莱尔投资管理WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.52% | 0.59% | #24 | $1.74亿 | 32.4万股 | $1.78亿 | 34.1万股 | -1.6万股-4.82% | 减仓 |
| 景顺Invesco Ltd. |
| 0.01% | 0.03% | #159 | $1.62亿 | 30.1万股 | $1.72亿 | 33.0万股 | -2.8万股-8.52% | 减仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 1.89% | 2.46% | #13 | $1.55亿 | 28.8万股 | $1.39亿 | 26.5万股 | +2.3万股+8.85% | 加仓 |
| LORD, ABBETT & CO. LLC |
| 0.43% | 0.41% | #29 | $1.51亿 | 28.2万股 | $1.27亿 | 24.3万股 | +3.9万股+15.97% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #168 | $1.32亿 | 24.6万股 | $1.45亿 | 27.7万股 | -3.1万股-11.21% | 减仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.31% | 0.54% | #36 | $1.31亿 | 24.4万股 | $1.51亿 | 28.9万股 | -4.5万股-15.57% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.03% | 0.01% | #126 | $1.24亿 | 23.1万股 | $5,139.6万 | 9.8万股 | +13.3万股+135.49% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | <0.01% | #169 | $1.15亿 | 21.4万股 | $3,113.5万 | 9.4万股 | +12.0万股+127.55% | 加仓 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.18% | 0.15% | #53 | $1.13亿 | 21.0万股 | $9,607.8万 | 18.4万股 | +2.7万股+14.53% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.1% | 0.1% | #70 | $1.03亿 | 19.3万股 | $9,791.4万 | 18.7万股 | +5,656股+3.02% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.01% | 0.02% | #179 | $1.01亿 | 18.7万股 | $1.72亿 | 32.8万股 | -14.1万股-42.94% | 减仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| 0.03% | 0.02% | #116 | $9,917.6万 | 18.9万股 | $7,305.3万 | 12.5万股 | +6.4万股+51.03% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.02% | #156 | $9,897.3万 | 18.4万股 | $1.13亿 | 21.7万股 | -3.2万股-14.95% | 减仓 |
| Caption管理Caption Management, LLC |
| 0.46% | 0.43% | #26 | $9,836.9万 | 18.3万股 | $7,328.6万 | 14.0万股 | +4.3万股+30.86% | 加仓 |
| 多伦多道明银行TORONTO DOMINION BANK |
| 0.11% | 0.1% | #66 | $9,742.0万 | 18.1万股 | $6,829.2万 | 13.0万股 | +5.1万股+39.07% | 加仓 |
| Rock Springs Capital Management LP |
| 4.59% | 5.28% | #7 | $9,396.6万 | 17.5万股 | $8,951.3万 | 17.1万股 | +4,000股+2.34% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.66% | 1.31% | #21 | $9,079.0万 | 16.9万股 | $1.31亿 | 25.0万股 | -8.0万股-32.23% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.04% | 0.04% | #106 | $8,713.1万 | 16.2万股 | $6,665.8万 | 12.7万股 | +3.5万股+27.43% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.19% | — | #52 | $8,211.3万 | 15.3万股 | $0 | 0股 | +15.3万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.08% | 0.16% | #75 | $7,658.5万 | 14.3万股 | $1.23亿 | 23.5万股 | -9.2万股-39.28% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | 0.01% | #255 | $7,464.1万 | 13.9万股 | $1.15亿 | 25.0万股 | -11.1万股-44.32% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | 0.01% | #243 | $7,197.1万 | 13.4万股 | $9,921.2万 | 19.0万股 | -5.5万股-29.28% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.01% | 0.01% | #171 | $6,900.9万 | 12.9万股 | $7,114.4万 | 13.6万股 | -7,388股-5.44% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.21% | 0.25% | #46 | $6,760.1万 | 12.6万股 | $6,590.4万 | 12.6万股 | 00.00% | 持仓不变 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.08% | 0.01% | #76 | $6,669.7万 | 12.4万股 | $839.3万 | 1.6万股 | +10.8万股+674.74% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.01% | 0.02% | #153 | $6,528.4万 | 12.2万股 | $6,704.6万 | 12.8万股 | -6,496股-5.07% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.02% | 0.01% | #137 | $6,362.6万 | 11.8万股 | $2,138.5万 | 4.1万股 | +7.8万股+190.05% | 加仓 |
| 清水投资Clearbridge Investments, LLC |
| 0.05% | 0.01% | #100 | $5,870.2万 | 10.9万股 | $1,279.7万 | 2.4万股 | +8.5万股+347.19% | 加仓 |
| 奥地利Erste资产管理Erste Asset Management GmbH |
| 0.45% | 0.75% | #27 | $5,811.2万 | 11.0万股 | $8,096.1万 | 16.0万股 | -5.0万股-31.21% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.04% | 0.01% | #103 | $5,469.3万 | 10.2万股 | $1,146.5万 | 2.2万股 | +8.0万股+365.07% | 加仓 |
| Fiera资本Fiera Capital Corp |
| 0.19% | 0.31% | #50 | $5,361.8万 | 10.0万股 | $9,109.0万 | 17.4万股 | -7.4万股-42.61% | 减仓 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| 0.02% | 0.04% | #130 | $5,337.2万 | 9.9万股 | $8,581.5万 | 16.4万股 | -6.5万股-39.37% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #223 | $5,289.5万 | 9.9万股 | $7,810.9万 | 14.9万股 | -5.1万股-33.98% | 减仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| 0.06% | 0.05% | #85 | $5,087.2万 | 9.5万股 | $3,932.8万 | 7.5万股 | +2.0万股+26.11% | 加仓 |
