| 贝莱德BlackRock, Inc. |
| 0.01% | 0.01% | #276 | $7.60亿 | 310.4万股 | $6.61亿 | 391.3万股 | -80.9万股-20.68% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.02% | 0.02% | #224 | $4.86亿 | 198.4万股 | $3.48亿 | 205.8万股 | -7.5万股-3.63% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #291 | $4.81亿 | 196.5万股 | $3.28亿 | 193.8万股 | +2.7万股+1.41% | 加仓 |
| 景顺Invesco Ltd. |
| 0.03% | 0.03% | #197 | $4.09亿 | 167.2万股 | $2.19亿 | 129.8万股 | +37.4万股+28.82% | 加仓 |
| 富达投资FMR LLC |
| 0.02% | 0.01% | #247 | $3.77亿 | 153.9万股 | $2.65亿 | 156.7万股 | -2.8万股-1.78% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #267 | $2.37亿 | 96.7万股 | $1.97亿 | 116.3万股 | -19.6万股-16.84% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.01% | #246 | $2.22亿 | 90.7万股 | $7,514.6万 | 44.5万股 | +46.3万股+104.10% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | <0.01% | #285 | $1.97亿 | 80.4万股 | $4,974.4万 | 41.0万股 | +39.5万股+96.32% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.01% | 0.01% | #336 | $1.92亿 | 78.6万股 | $1.67亿 | 98.7万股 | -20.1万股-20.38% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.02% | <0.01% | #253 | $1.84亿 | 75.0万股 | $3,317.5万 | 19.6万股 | +55.4万股+282.01% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 2.49% | 3.04% | #14 | $1.71亿 | 70.0万股 | $1.86亿 | 110.0万股 | -40.0万股-36.36% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.12% | 0.04% | #111 | $1.66亿 | 68.0万股 | $5,518.1万 | 32.6万股 | +35.4万股+108.28% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.03% | 0.02% | #193 | $1.64亿 | 66.8万股 | $7,411.4万 | 43.8万股 | +23.0万股+52.43% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.03% | 0.04% | #207 | $1.60亿 | 65.4万股 | $1.94亿 | 114.5万股 | -49.1万股-42.90% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.08% | 0.06% | #138 | $1.60亿 | 65.3万股 | $1.03亿 | 60.7万股 | +4.6万股+7.61% | 加仓 |
| ALETHEA CAPITAL MANAGEMENT, LLC |
| 65.78% | 56.28% | #1 | $1.59亿 | 64.9万股 | $1.10亿 | 64.9万股 | -358股-0.06% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.03% | #252 | $1.57亿 | 64.3万股 | $2.23亿 | 131.7万股 | -67.4万股-51.19% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| 0.05% | <0.01% | #171 | $1.40亿 | 57.1万股 | $859.6万 | 5.1万股 | +52.0万股+1,023.30% | 加仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.2% | 0.24% | #77 | $1.32亿 | 53.9万股 | $1.37亿 | 81.3万股 | -27.3万股-33.64% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.01% | 0.01% | #259 | $1.26亿 | 51.5万股 | $7,115.8万 | 42.1万股 | +9.4万股+22.37% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | 0.01% | #268 | $1.26亿 | 51.4万股 | $5,102.5万 | 43.7万股 | +7.7万股+17.55% | 加仓 |
| 第一信托顾问FIRST TRUST ADVISORS LP |
| 0.07% | 0.07% | #150 | $1.18亿 | 48.2万股 | $9,760.6万 | 57.7万股 | -9.5万股-16.52% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.13% | 0.09% | #101 | $1.17亿 | 48.0万股 | $7,179.1万 | 42.5万股 | +5.5万股+12.96% | 加仓 |
| Assenagon资产管理Assenagon Asset Management S.A. |
| 0.14% | 0.22% | #95 | $1.11亿 | 45.5万股 | $1.46亿 | 86.6万股 | -41.1万股-47.49% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.01% | 0.01% | #320 | $1.11亿 | 45.2万股 | $1.01亿 | 59.8万股 | -14.6万股-24.34% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| 0.02% | 0.01% | #227 | $1.05亿 | 42.8万股 | $2,980.1万 | 17.6万股 | +25.2万股+142.79% | 加仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.1% | 0.07% | #122 | $1.04亿 | 42.7万股 | $7,030.6万 | 41.6万股 | +1.1万股+2.53% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| 0.1% | 0.06% | #125 | $1.04亿 | 42.6万股 | $5,667.8万 | 33.5万股 | +9.1万股+27.14% | 加仓 |
| Hood River资本管理Hood River Capital Management LLC |
| 0.71% | 0.63% | #36 | $9,856.3万 | 40.3万股 | $6,279.1万 | 37.2万股 | +3.1万股+8.39% | 加仓 |
| 安大略医疗养老基金(HOOPP)HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND |
| 0.13% | 0.03% | #103 | $9,131.6万 | 37.3万股 | $1,648.8万 | 9.8万股 | +27.6万股+282.44% | 加仓 |
| Driehaus资本管理DRIEHAUS CAPITAL MANAGEMENT LLC |
| 0.53% | 0.36% | #47 | $9,117.0万 | 37.2万股 | $4,941.6万 | 29.2万股 | +8.0万股+27.40% | 加仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.04% | 0.03% | #181 | $8,142.1万 | 33.3万股 | $5,923.9万 | 35.0万股 | -1.8万股-5.09% | 减仓 |
| 暮色资产管理EVENTIDE ASSET MANAGEMENT, LLC |
| 1.04% | 1.45% | #29 | $7,753.5万 | 31.7万股 | $8,777.7万 | 52.0万股 | -20.3万股-39.02% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.01% | 0.01% | #289 | $7,737.3万 | 31.6万股 | $6,678.3万 | 39.5万股 | -7.9万股-20.00% | 减仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 2.9% | 0.28% | #12 | $7,343.1万 | 30.0万股 | $591.6万 | 3.5万股 | +26.5万股+757.14% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.01% | #254 | $6,847.1万 | 28.0万股 | $4,988.4万 | 29.5万股 | -1.5万股-5.22% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.01% | 0.01% | #312 | $6,613.4万 | 27.0万股 | $6,785.5万 | 40.1万股 | -13.1万股-32.70% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.09% | 0.04% | #130 | $6,413.0万 | 26.2万股 | $2,777.0万 | 16.4万股 | +9.8万股+59.46% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.09% | 0.19% | #128 | $6,340.4万 | 25.9万股 | $1.25亿 | 73.8万股 | -47.9万股-64.88% | 减仓 |
| Frontier资本管理FRONTIER CAPITAL MANAGEMENT CO LLC |
| 0.58% | 0.35% | #40 | $6,224.0万 | 25.4万股 | $3,432.2万 | 20.3万股 | +5.1万股+25.22% | 加仓 |
| 萨姆林资本SAMLYN CAPITAL, LLC |
| 0.98% | — | #31 | $6,021.7万 | 24.6万股 | $0 | 0股 | +24.6万股 | 新买入 |
| 清水投资Clearbridge Investments, LLC |
| 0.05% | 0.01% | #167 | $6,010.9万 | 24.6万股 | $760.9万 | 4.5万股 | +20.1万股+445.48% | 加仓 |
| 卢米斯塞勒斯LOOMIS SAYLES & CO L P |
| 0.07% | 0.06% | #141 | $5,862.0万 | 23.9万股 | $4,337.5万 | 25.7万股 | -1.7万股-6.68% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| 0.03% | 0.02% | #208 | $5,653.1万 | 23.1万股 | $3,180.0万 | 18.8万股 | +4.3万股+22.75% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | 0.01% | #346 | $5,621.6万 | 23.0万股 | $7,123.3万 | 42.1万股 | -19.2万股-45.50% | 减仓 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| 0.03% | 0.01% | #202 | $5,517.1万 | 22.5万股 | $1,544.8万 | 9.1万股 | +13.4万股+146.61% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| 0.04% | 0.02% | #176 | $5,467.8万 | 22.3万股 | $2,387.2万 | 14.1万股 | +8.2万股+58.17% | 加仓 |
| PFM Health Sciences, LP |
| 4.61% | 4.07% | #6 | $5,375.1万 | 22.0万股 | $4,467.3万 | 26.4万股 | -4.5万股-16.92% | 减仓 |
| Tri Locum Partners LP |
| 6.6% | 1.47% | #3 | $5,368.0万 | 21.9万股 | $1,049.9万 | 6.2万股 | +15.7万股+253.06% | 加仓 |
| First Turn Management, LLC |
| 5.72% | 3.56% | #4 | $5,346.1万 | 21.8万股 | $3,190.6万 | 18.9万股 | +3.0万股+15.70% | 加仓 |
