| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.44% | 0.77% | #3 | $1,318.9万 | 1,232.6万股 | $2,099.0万 | 559.7万股 | +672.9万股+120.21% | 加仓 |
| Redmile Group, LLC |
| 0.83% | 3.84% | #2 | $1,233.4万 | 1,152.7万股 | $5,801.4万 | 1,547.1万股 | -394.4万股-25.49% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.29% | 1.22% | #4 | $1,218.7万 | 1,139.0万股 | $4,271.3万 | 1,139.0万股 | 00.00% | 持仓不变 |
| Prosight Management, LP |
| 1.44% | 5.1% | #1 | $837.2万 | 782.5万股 | $3,112.5万 | 830.0万股 | -47.5万股-5.73% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #55 | $751.2万 | 702.0万股 | $2,344.0万 | 625.1万股 | +76.9万股+12.31% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | 0.02% | #15 | $393.3万 | 367.6万股 | $1,278.2万 | 340.9万股 | +26.7万股+7.83% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #50 | $326.5万 | 305.1万股 | $1,467.6万 | 366.9万股 | -61.8万股-16.84% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | 0.01% | #22 | $326.3万 | 305.0万股 | $1,220.3万 | 325.4万股 | -20.5万股-6.29% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #41 | $219.7万 | 205.3万股 | $149.9万 | 40.0万股 | +165.4万股+413.69% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #49 | $204.8万 | 191.4万股 | $619.9万 | 165.3万股 | +26.1万股+15.81% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #63 | $180.4万 | 168.6万股 | $587.5万 | 156.7万股 | +11.9万股+7.61% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #58 | $154.7万 | 144.6万股 | $451.4万 | 120.4万股 | +24.2万股+20.09% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #57 | $137.8万 | 128.8万股 | $496.9万 | 132.5万股 | -3.7万股-2.78% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #67 | $96.0万 | 89.7万股 | $387.5万 | 103.3万股 | -13.6万股-13.18% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $82.8万 | 77.3万股 | $250.5万 | 66.8万股 | +10.5万股+15.78% | 加仓 |
| Blue Owl Capital Holdings LP |
| 0.11% | 0.7% | #6 | $78.5万 | 73.4万股 | $258.9万 | 73.4万股 | 00.00% | 持仓不变 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #35 | $77.0万 | 71.9万股 | $91.2万 | 24.3万股 | +47.6万股+195.80% | 加仓 |
| Opaleye Management Inc. |
| 0.07% | — | #7 | $74.9万 | 70.0万股 | $0 | 0股 | +70.0万股 | 新买入 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #42 | $70.4万 | 65.8万股 | $89.1万 | 23.8万股 | +42.0万股+176.95% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #37 | $69.9万 | 65.3万股 | $322.7万 | 86.0万股 | -20.8万股-24.13% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #59 | $63.6万 | 59.4万股 | $207.1万 | 55.2万股 | +4.2万股+7.57% | 加仓 |
| PLATINUM INVESTMENT MANAGEMENT LTD |
| 0.15% | 0.94% | #5 | $62.2万 | 58.2万股 | $371.5万 | 99.1万股 | -40.9万股-41.30% | 减仓 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| <0.01% | 0.01% | #21 | $61.3万 | 57.3万股 | $259.2万 | 69.1万股 | -11.8万股-17.14% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #60 | $55.7万 | 52.0万股 | $172.1万 | 45.9万股 | +6.1万股+13.38% | 加仓 |
| 施罗德投资管理SCHRODER INVESTMENT MANAGEMENT GROUP |
| <0.01% | <0.01% | #38 | $43.1万 | 41.9万股 | $152.4万 | 41.9万股 | 00.00% | 持仓不变 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #31 | $38.5万 | 36.0万股 | $168.0万 | 44.9万股 | -8.9万股-19.79% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #64 | $32.9万 | 30.7万股 | $98.5万 | 26.3万股 | +4.4万股+16.88% | 加仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #44 | $30.7万 | 28.7万股 | $95.6万 | 25.5万股 | +3.2万股+12.43% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #66 | $26.9万 | 25.2万股 | $75.8万 | 20.2万股 | +4.9万股+24.42% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #68 | $25.1万 | 23.4万股 | $86.6万 | 23.1万股 | +3,291股+1.42% | 加仓 |
| Florida Trust 财富管理Florida Trust Wealth Management Co |
| 0.01% | 0.02% | #14 | $24.7万 | 23.0万股 | $56.4万 | 15.0万股 | +8.0万股+53.18% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #73 | $24.0万 | 22.4万股 | $84.1万 | 22.4万股 | -303股-0.14% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #65 | $18.9万 | 17.7万股 | $54.8万 | 14.6万股 | +3.0万股+20.81% | 加仓 |
| 威斯康星州投资委员会STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #36 | $17.1万 | 16.0万股 | $47.6万 | 12.7万股 | +3.3万股+26.32% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #86 | $15.7万 | 15.3万股 | $178.0万 | 48.9万股 | -33.7万股-68.81% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | — | #28 | $15.1万 | 14.1万股 | $0 | 0股 | +14.1万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #20 | $15.0万 | 14.0万股 | $6.5万 | 1.7万股 | +12.3万股+705.54% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #89 | $14.2万 | 13.3万股 | $64.8万 | 17.3万股 | -4.0万股-23.11% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #56 | $12.6万 | 11.7万股 | $39.0万 | 10.4万股 | +1.3万股+12.79% | 加仓 |
| Focus Partners财富Focus Partners Wealth |
| <0.01% | — | #54 | $12.0万 | 11.2万股 | $0 | 0股 | +11.2万股 | 新买入 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #24 | $11.3万 | 10.6万股 | $0 | 0股 | +10.6万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #70 | $10.8万 | 10.8万股 | $14.8万 | 4.2万股 | +6.7万股+159.19% | 加仓 |
| Wilmington Savings Fund Society, FSB |
| <0.01% | 0.01% | #19 | $10.7万 | 10.0万股 | $37.5万 | 10.0万股 | 00.00% | 持仓不变 |
| Revolve Wealth Partners, LLC |
| 0.01% | — | #12 | $10.7万 | 10.0万股 | $0 | 0股 | +10.0万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #79 | $10.1万 | 9.4万股 | $17.4万 | 4.6万股 | +4.8万股+103.44% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #75 | $8.9万 | 8.3万股 | $30.1万 | 8.0万股 | +3,239股+4.04% | 加仓 |
| DAFNA Capital Management LLC |
| 0.02% | 0.06% | #9 | $8.2万 | 7.7万股 | $27.0万 | 7.2万股 | +5,000股+6.94% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #87 | $8.0万 | 7.5万股 | $26.3万 | 7.0万股 | +4,813股+6.87% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #90 | $6.6万 | 6.1万股 | $58.0万 | 15.5万股 | -9.3万股-60.41% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #84 | $6.0万 | 5.7万股 | $33.3万 | 8.9万股 | -3.2万股-36.45% | 减仓 |
