| Nextech Invest Ltd. |
| 0.2% | 1.37% | #3 | $411.0万 | 741.9万股 | $1,943.9万 | 741.9万股 | 00.00% | 持仓不变 |
| 深轨资本Deep Track Capital, LP |
| 0.06% | 0.32% | #6 | $411.0万 | 741.9万股 | $1,943.9万 | 741.9万股 | 00.00% | 持仓不变 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.13% | 0.74% | #5 | $391.2万 | 706.3万股 | $1,824.3万 | 696.3万股 | +10.0万股+1.44% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #37 | $341.7万 | 616.9万股 | $221.8万 | 84.7万股 | +532.3万股+628.63% | 加仓 |
| Avidity Partners Management LP |
| 0.44% | 2.65% | #1 | $276.9万 | 499.8万股 | $1,309.5万 | 499.8万股 | 00.00% | 持仓不变 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #22 | $210.7万 | 380.3万股 | $996.5万 | 380.3万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #38 | $190.1万 | 343.2万股 | $899.2万 | 343.2万股 | +99股+0.00% | 加仓 |
| Octagon Capital Advisors LP |
| 0.15% | 1.52% | #4 | $168.9万 | 305.0万股 | $1,375.5万 | 525.0万股 | -220.0万股-41.90% | 减仓 |
| Blue Owl Capital Holdings LP |
| 0.24% | 3.58% | #2 | $162.5万 | 293.4万股 | $1,333.3万 | 508.9万股 | -215.5万股-42.35% | 减仓 |
| TCG Crossover 管理TCG Crossover Management, LLC |
| 0.04% | 0.2% | #8 | $148.6万 | 268.3万股 | $702.9万 | 268.3万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #35 | $101.4万 | 183.0万股 | $158.3万 | 60.4万股 | +122.7万股+203.15% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #46 | $78.3万 | 141.3万股 | $61.2万 | 23.4万股 | +118.0万股+505.30% | 加仓 |
| MPM BioImpact LLC |
| 0.04% | 2.16% | #7 | $72.0万 | 129.9万股 | $2,798.0万 | 1,067.9万股 | -938.0万股-87.84% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #19 | $57.7万 | 104.1万股 | $47.9万 | 18.3万股 | +85.8万股+469.07% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | — | #20 | $56.0万 | 101.1万股 | $0 | 0股 | +101.1万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.05% | #10 | $41.6万 | 75.1万股 | $92.0万 | 35.1万股 | +40.0万股+113.89% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #41 | $35.7万 | 64.5万股 | $114.5万 | 43.7万股 | +20.8万股+47.67% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #49 | $35.4万 | 63.9万股 | $0 | 0股 | +63.9万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #39 | $34.1万 | 61.6万股 | $27.1万 | 10.3万股 | +51.2万股+496.16% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $24.0万 | 43.4万股 | $89.4万 | 34.1万股 | +9.3万股+27.11% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | 0.01% | #28 | $21.1万 | 38.5万股 | $772.5万 | 294.8万股 | -256.4万股-86.96% | 减仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #16 | $16.3万 | 29.4万股 | $0 | 0股 | +29.4万股 | 新买入 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #30 | $14.2万 | 25.7万股 | $3.0万 | 1.1万股 | +24.6万股+2,155.38% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #47 | $12.6万 | 22.8万股 | $0 | 0股 | +22.8万股 | 新买入 |
| Pathstone控股Pathstone Holdings, LLC |
| <0.01% | <0.01% | #25 | $11.9万 | 21.5万股 | $28.9万 | 11.0万股 | +10.5万股+94.91% | 加仓 |
| Timothy G. Youngquist 2020 Irrevocable Trust |
| <0.01% | — | #13 | $11.0万 | 19.8万股 | $0 | 0股 | +19.8万股 | 新买入 |
| 格雷厄姆资本管理Graham Capital Management, L.P. |
| <0.01% | — | #17 | $9.1万 | 16.4万股 | $0 | 0股 | +16.4万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | — | #12 | $8.9万 | 16.0万股 | $0 | 0股 | +16.0万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #44 | $8.2万 | 14.7万股 | $373.2万 | 142.4万股 | -127.7万股-89.66% | 减仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #33 | $7.5万 | 13.5万股 | $0 | 0股 | +13.5万股 | 新买入 |
| HighTower顾问HighTower Advisors, LLC |
| <0.01% | <0.01% | #34 | $7.0万 | 12.6万股 | $33.1万 | 12.6万股 | -300股-0.24% | 减仓 |
| Private Advisor集团Private Advisor Group, LLC |
| <0.01% | — | #26 | $7.0万 | 12.6万股 | $0 | 0股 | +12.6万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #48 | $7.0万 | 12.6万股 | $0 | 0股 | +12.6万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #55 | $6.1万 | 10.9万股 | $0 | 0股 | +10.9万股 | 新买入 |
| 法国外贸银行(Natixis)NATIXIS |
| <0.01% | — | #27 | $5.5万 | 9.7万股 | $0 | 0股 | +9.7万股 | 新买入 |
| Clear Harbor Asset Management, LLC |
| <0.01% | 0.02% | #14 | $5.1万 | 9.3万股 | $24.3万 | 9.3万股 | 00.00% | 持仓不变 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #50 | $5.0万 | 9.1万股 | $0 | 0股 | +9.1万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #58 | $4.7万 | 8.5万股 | $0 | 0股 | +8.5万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| <0.01% | <0.01% | #29 | $4.3万 | 7.8万股 | $65.5万 | 25.0万股 | -17.2万股-68.84% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #62 | $4.3万 | 7.8万股 | $0 | 0股 | +7.8万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #52 | $3.9万 | 7.0万股 | $3.2万 | 1.2万股 | +5.8万股+477.27% | 加仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #42 | $3.9万 | 7.0万股 | $0 | 0股 | +7.0万股 | 新买入 |
| TWO SIGMA SECURITIES, LLC |
| <0.01% | <0.01% | #15 | $3.4万 | 6.1万股 | $3.3万 | 1.3万股 | +4.9万股+388.70% | 加仓 |
| Velan Capital Investment Management LP |
| 0.02% | 0.16% | #9 | $3.3万 | 6.0万股 | $26.2万 | 10.0万股 | -4.0万股-40.30% | 减仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | — | #53 | $3.3万 | 5.9万股 | $0 | 0股 | +5.9万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #70 | $3.0万 | 5.3万股 | $30.1万 | 11.5万股 | -6.1万股-53.52% | 减仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #40 | $2.9万 | 5.3万股 | $0 | 0股 | +5.3万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #68 | $2.8万 | 5.1万股 | $0 | 0股 | +5.1万股 | 新买入 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #43 | $2.4万 | 4.3万股 | $0 | 0股 | +4.3万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #71 | $2.2万 | 3.9万股 | $2.6万 | 1.0万股 | +2.8万股+270.57% | 加仓 |
