| RTW投资RTW INVESTMENTS, LP |
| 0.35% | 0.35% | #3 | $4,123.4万 | 955.6万股 | $3,530.1万 | 830.6万股 | +125.0万股+15.05% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.33% | 0.42% | #4 | $2,173.9万 | 503.8万股 | $2,141.1万 | 503.8万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #39 | $1,083.2万 | 251.0万股 | $270.2万 | 63.6万股 | +187.5万股+294.89% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $872.9万 | 202.3万股 | $936.8万 | 220.4万股 | -18.1万股-8.23% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $435.0万 | 100.8万股 | $206.4万 | 48.5万股 | +52.2万股+107.61% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #13 | $431.5万 | 100.0万股 | $425.0万 | 100.0万股 | 00.00% | 持仓不变 |
| Propel Bio Management, LLC |
| 2.02% | 2.41% | #1 | $386.9万 | 89.7万股 | $383.1万 | 89.7万股 | 00.00% | 持仓不变 |
| 瑞银资产管理(美洲)UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
| <0.01% | — | #27 | $277.1万 | 64.2万股 | $0 | 0股 | +64.2万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #46 | $222.7万 | 51.6万股 | $72.0万 | 16.9万股 | +34.7万股+204.62% | 加仓 |
| RICE HALL JAMES & ASSOCIATES, LLC |
| 0.09% | <0.01% | #8 | $183.0万 | 42.4万股 | $8.1万 | 1.9万股 | +40.5万股+2,131.46% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #35 | $150.8万 | 35.0万股 | $112.8万 | 26.5万股 | +8.4万股+31.66% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #38 | $148.3万 | 34.4万股 | $50.3万 | 11.8万股 | +22.5万股+190.55% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #37 | $140.6万 | 32.6万股 | $21.4万 | 5.0万股 | +27.5万股+547.53% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #33 | $126.1万 | 29.2万股 | $100.0万 | 23.5万股 | +5.7万股+24.25% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #50 | $118.7万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
| Knott David M Jr |
| 0.58% | 0.65% | #2 | $109.5万 | 25.4万股 | $107.8万 | 25.4万股 | 00.00% | 持仓不变 |
| Flat Footed LLC |
| 0.08% | — | #9 | $108.5万 | 25.1万股 | $0 | 0股 | +25.1万股 | 新买入 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.01% | 0.01% | #11 | $94.7万 | 21.9万股 | $93.2万 | 21.9万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #45 | $77.5万 | 18.0万股 | $66.0万 | 15.5万股 | +2.4万股+15.69% | 加仓 |
| DAFNA Capital Management LLC |
| 0.1% | 0.12% | #6 | $54.7万 | 12.7万股 | $53.9万 | 12.7万股 | 00.00% | 持仓不变 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #26 | $38.8万 | 9.0万股 | $30.1万 | 7.1万股 | +1.9万股+26.94% | 加仓 |
| IFP顾问IFP Advisors, Inc |
| 0.01% | 0.01% | #16 | $38.7万 | 9.0万股 | $42.0万 | 9.9万股 | -9,279股-9.38% | 减仓 |
| Daytona Street Capital LLC |
| 0.28% | 0.18% | #5 | $37.9万 | 9.6万股 | $23.5万 | 5.3万股 | +4.4万股+83.27% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #47 | $37.2万 | 8.6万股 | $0 | 0股 | +8.6万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #53 | $37.1万 | 8.6万股 | $33.7万 | 7.9万股 | +6,706股+8.47% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #19 | $34.8万 | 8.1万股 | $30.0万 | 7.1万股 | +1.0万股+14.16% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #57 | $28.4万 | 6.6万股 | $41.4万 | 9.8万股 | -3.2万股-32.52% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | — | #49 | $22.5万 | 5.2万股 | $0 | 0股 | +5.2万股 | 新买入 |
| Holos Integrated Wealth LLC |
| 0.1% | 0.11% | #7 | $20.4万 | 5.2万股 | $22.0万 | 5.2万股 | 00.00% | 持仓不变 |
| NewEdge顾问NewEdge Advisors, LLC |
| <0.01% | <0.01% | #25 | $19.0万 | 4.4万股 | $18.7万 | 4.4万股 | 00.00% | 持仓不变 |
| Y截距(香港)Y-Intercept (Hong Kong) Ltd |
| <0.01% | — | #21 | $18.8万 | 4.3万股 | $0 | 0股 | +4.3万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #52 | $17.1万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #23 | $16.7万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #56 | $15.7万 | 3.6万股 | $0 | 0股 | +3.6万股 | 新买入 |
| HighTower顾问HighTower Advisors, LLC |
| <0.01% | <0.01% | #40 | $15.3万 | 3.5万股 | $7.8万 | 1.8万股 | +1.7万股+93.57% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.01% | 0.09% | #18 | $14.4万 | 3.3万股 | $171.1万 | 40.3万股 | -36.9万股-91.70% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #60 | $14.1万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #42 | $13.8万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $12.6万 | 2.9万股 | $2.6万 | 1.0万股 | +1.9万股+182.48% | 加仓 |
| Algert全球ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #24 | $12.3万 | 2.8万股 | $6.2万 | 1.5万股 | +1.4万股+94.36% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #64 | $11.5万 | 2.7万股 | $30.2万 | 7.1万股 | -4.4万股-62.30% | 减仓 |
| Meramec Financial Planners, LLC |
| 0.04% | 0.05% | #10 | $11.5万 | 3.0万股 | $13.1万 | 3.0万股 | 00.00% | 持仓不变 |
| AXQ CAPITAL, LP |
| 0.01% | — | #12 | $11.0万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #66 | $10.7万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| 大都会人寿投资管理MetLife Investment Management, LLC |
| <0.01% | — | #28 | $10.4万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #69 | $10.3万 | 2.4万股 | $22.4万 | 5.3万股 | -2.9万股-54.85% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #70 | $9.9万 | 2.1万股 | $1.7万 | 4,258股 | +1.7万股+390.37% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #44 | $9.7万 | 2.3万股 | $25.5万 | 6.0万股 | -3.8万股-62.46% | 减仓 |
| 加拿大养老金计划投资委员会(CPPIB)CANADA PENSION PLAN INVESTMENT BOARD |
| <0.01% | <0.01% | #51 | $9.1万 | 2.1万股 | $4.8万 | 1.1万股 | +9,800股+86.73% | 加仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #41 | $8.8万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
