| AIGH Capital Management LLC |
| 0.85% | — | #1 | $1,350.0万 | 25.0万股 | $0 | 0股 | +25.0万股 | 新买入 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.2% | — | #9 | $1,080.0万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #38 | $1,014.3万 | 18.8万股 | $110.7万 | 1.7万股 | +17.1万股+1,008.96% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #21 | $869.3万 | 16.1万股 | $731.2万 | 11.2万股 | +4.9万股+43.88% | 加仓 |
| AWM Investment Company, Inc. |
| 0.69% | — | #3 | $793.7万 | 14.7万股 | $0 | 0股 | +14.7万股 | 新买入 |
| Ikarian Capital, LLC |
| 0.7% | 0.64% | #2 | $655.3万 | 12.1万股 | $793.1万 | 12.1万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | — | #40 | $644.4万 | 11.9万股 | $0 | 0股 | +11.9万股 | 新买入 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #19 | $441.0万 | 8.2万股 | $337.7万 | 5.2万股 | +3.0万股+58.06% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $381.0万 | 7.1万股 | $84.3万 | 1.3万股 | +5.8万股+447.35% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.17% | 0.23% | #11 | $365.7万 | 6.8万股 | $383.0万 | 5.9万股 | +9,117股+15.56% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #29 | $280.3万 | 5.2万股 | $457.4万 | 7.0万股 | -1.8万股-25.85% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #44 | $272.4万 | 5.0万股 | $35.3万 | 5,400股 | +4.5万股+834.26% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.03% | 0.04% | #16 | $227.2万 | 4.2万股 | $275.0万 | 4.2万股 | 00.00% | 持仓不变 |
| STEMPOINT CAPITAL LP |
| 0.32% | 0.08% | #5 | $223.5万 | 4.1万股 | $41.6万 | 6,360股 | +3.5万股+550.75% | 加仓 |
| Eversept Partners, LP |
| 0.11% | — | #13 | $216.0万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 凯雷集团Carlyle Group Inc. |
| 0.02% | 0.02% | #17 | $208.5万 | 3.9万股 | $252.4万 | 3.9万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #37 | $174.7万 | 3.2万股 | $36.0万 | 5,506股 | +2.7万股+487.50% | 加仓 |
| Affinity Asset Advisors, LLC |
| 0.07% | — | #14 | $162.0万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| DIADEMA PARTNERS LP |
| 0.2% | 0.11% | #10 | $162.0万 | 3.0万股 | $65.4万 | 1.0万股 | +2.0万股+200.00% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.24% | — | #8 | $155.5万 | 2.9万股 | $0 | 0股 | +2.9万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #22 | $152.7万 | 2.8万股 | $0 | 0股 | +2.8万股 | 新买入 |
| Quinn Opportunity Partners LLC |
| 0.07% | 0.09% | #15 | $144.8万 | 2.7万股 | $175.2万 | 2.7万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #36 | $126.3万 | 2.3万股 | $25.6万 | 3,919股 | +1.9万股+496.61% | 加仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| 0.01% | — | #20 | $118.8万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #41 | $113.8万 | 2.1万股 | $0 | 0股 | +2.1万股 | 新买入 |
| Rosalind Advisors, Inc. |
| 0.26% | — | #7 | $108.0万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| Knott David M Jr |
| 0.58% | — | #4 | $108.0万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | — | #33 | $101.7万 | 1.9万股 | $0 | 0股 | +1.9万股 | 新买入 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #47 | $99.9万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | — | #32 | $99.1万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #23 | $65.5万 | 1.2万股 | $261.4万 | 4.0万股 | -2.8万股-69.66% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #43 | $47.7万 | 8,813股 | $0 | 0股 | +8,813股 | 新买入 |
| Persistent Asset Partners Ltd |
| 0.13% | 0.06% | #12 | $41.5万 | 7,677股 | $16.5万 | 2,528股 | +5,149股+203.68% | 加仓 |
| 佛罗里达州退休系统STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
| <0.01% | — | #24 | $38.8万 | 7,182股 | $0 | 0股 | +7,182股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #46 | $36.6万 | 6,779股 | $0 | 0股 | +6,779股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #48 | $31.8万 | 5,896股 | $0 | 0股 | +5,896股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #27 | $25.4万 | 4,700股 | $0 | 0股 | +4,700股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #53 | $23.8万 | 4,411股 | $878 | 98股 | +4,313股+4,401.02% | 加仓 |
| Pale Fire Capital SE |
| 0.01% | — | #18 | $20.6万 | 3,818股 | $0 | 0股 | +3,818股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #39 | $19.0万 | 3,519股 | $0 | 0股 | +3,519股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #49 | $14.3万 | 2,652股 | $0 | 0股 | +2,652股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #52 | $12.6万 | 2,329股 | $0 | 0股 | +2,329股 | 新买入 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #42 | $10.3万 | 1,900股 | $0 | 0股 | +1,900股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #51 | $6.8万 | 1,265股 | $6.1万 | 939股 | +326股+34.72% | 加仓 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #45 | $6.8万 | 1,252股 | $0 | 0股 | +1,252股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #58 | $6.3万 | 1,127股 | $0 | 0股 | +1,127股 | 新买入 |
| Lion Point Capital, LP |
| 0.26% | 0.39% | #6 | $5.4万 | 1,000股 | $6.5万 | 1,000股 | 00.00% | 持仓不变 |
| 新泽西州警察消防退休系统Police & Firemen's Retirement System of New Jersey |
| <0.01% | — | #26 | $4.7万 | 864股 | $0 | 0股 | +864股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #57 | $3.6万 | 674股 | $0 | 0股 | +674股 | 新买入 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | — | #54 | $2.4万 | 453股 | $0 | 0股 | +453股 | 新买入 |
