| TANG CAPITAL MANAGEMENT LLC |
| 1.29% | — | #4 | $2,850.5万 | 155.0万股 | $0 | 0股 | +155.0万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #39 | $1,841.4万 | 100.1万股 | $590.9万 | 76.4万股 | +23.7万股+30.98% | 加仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.28% | — | #9 | $1,839.0万 | 100.0万股 | $0 | 0股 | +100.0万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.63% | — | #6 | $1,839.0万 | 100.0万股 | $0 | 0股 | +100.0万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $1,604.5万 | 87.2万股 | $510.1万 | 66.0万股 | +21.3万股+32.22% | 加仓 |
| IRIDIAN ASSET MANAGEMENT LLC/CT |
| 4.91% | 2.04% | #1 | $1,429.0万 | 77.7万股 | $503.8万 | 65.2万股 | +12.5万股+19.23% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #33 | $795.1万 | 43.2万股 | $297.0万 | 38.4万股 | +4.8万股+12.54% | 加仓 |
| Occam Crest Management LP |
| 4.06% | 1.91% | #2 | $738.9万 | 35.7万股 | $314.7万 | 40.7万股 | -5.0万股-12.28% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.92% | — | #5 | $704.2万 | 38.3万股 | $0 | 0股 | +38.3万股 | 新买入 |
| BALDWIN WEALTH PARTNERS LLC/MA |
| 0.46% | 0.21% | #8 | $702.5万 | 38.2万股 | $292.7万 | 37.9万股 | +3,390股+0.90% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #32 | $570.8万 | 31.0万股 | $81.4万 | 10.5万股 | +20.5万股+194.80% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | — | #20 | $505.7万 | 27.5万股 | $0 | 0股 | +27.5万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #49 | $456.4万 | 24.8万股 | $128.7万 | 16.7万股 | +8.2万股+49.05% | 加仓 |
| Avidity Partners Management LP |
| 0.59% | — | #7 | $367.8万 | 20.0万股 | $0 | 0股 | +20.0万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #34 | $335.1万 | 18.2万股 | $60.6万 | 7.8万股 | +10.4万股+132.36% | 加仓 |
| Caption管理Caption Management, LLC |
| 0.01% | — | #19 | $294.8万 | 16.0万股 | $0 | 0股 | +16.0万股 | 新买入 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #38 | $269.8万 | 14.7万股 | $96.0万 | 12.4万股 | +2.3万股+18.12% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #30 | $234.6万 | 12.8万股 | $88.8万 | 11.5万股 | +1.3万股+11.07% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #44 | $228.6万 | 12.4万股 | $14.2万 | 1.8万股 | +10.6万股+575.45% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #53 | $217.5万 | 11.8万股 | $71.2万 | 9.2万股 | +2.6万股+28.37% | 加仓 |
| Kalehua Capital Management LLC |
| 1.32% | — | #3 | $183.9万 | 10.0万股 | $0 | 0股 | +10.0万股 | 新买入 |
| 奥本海默公司OPPENHEIMER & CO INC |
| 0.01% | 0.01% | #18 | $135.3万 | 7.4万股 | $56.9万 | 7.4万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #47 | $127.3万 | 6.9万股 | $29.8万 | 3.9万股 | +3.1万股+79.45% | 加仓 |
| FORBES J M & CO LLP |
| 0.09% | — | #12 | $108.5万 | 5.9万股 | $0 | 0股 | +5.9万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #48 | $105.1万 | 5.7万股 | $38.4万 | 5.0万股 | +7,488股+15.08% | 加仓 |
| CIBC美国CIBC Bancorp USA Inc. |
| <0.01% | <0.01% | #24 | $91.8万 | 6.7万股 | $19.8万 | 2.6万股 | +4.1万股+161.69% | 加仓 |
| Informed Momentum Co LLC |
| 0.08% | — | #14 | $86.7万 | 4.7万股 | $0 | 0股 | +4.7万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #45 | $75.1万 | 4.1万股 | $12.9万 | 1.7万股 | +2.4万股+143.73% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.11% | — | #11 | $73.6万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| Squadron Capital Management LLC |
| 0.22% | — | #10 | $71.2万 | 3.9万股 | $0 | 0股 | +3.9万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #51 | $67.6万 | 3.7万股 | $23.4万 | 3.0万股 | +6,455股+21.29% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | — | #42 | $58.6万 | 3.2万股 | $0 | 0股 | +3.2万股 | 新买入 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #35 | $57.7万 | 3.1万股 | $2.0万 | 2,596股 | +2.9万股+1,109.32% | 加仓 |
| SEI投资SEI INVESTMENTS CO |
| <0.01% | — | #31 | $51.4万 | 2.8万股 | $0 | 0股 | +2.8万股 | 新买入 |
| 俄亥俄州教师退休系统(STRS)STRS OHIO |
| <0.01% | — | #23 | $50.0万 | 2.7万股 | $0 | 0股 | +2.7万股 | 新买入 |
| Shay Capital LLC |
| 0.02% | — | #16 | $38.6万 | 2.1万股 | $0 | 0股 | +2.1万股 | 新买入 |
| Austin Wealth Management, LLC |
| 0.08% | 0.03% | #13 | $38.5万 | 2.0万股 | $15.4万 | 2.0万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #63 | $37.7万 | 2.0万股 | $31.8万 | 4.1万股 | -2.1万股-50.20% | 减仓 |
| DAFNA Capital Management LLC |
| 0.07% | — | #15 | $36.8万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #71 | $34.4万 | 1.9万股 | $11.1万 | 1.9万股 | +204股+1.10% | 加仓 |
| MARTINGALE ASSET MANAGEMENT L P |
| 0.01% | <0.01% | #21 | $33.1万 | 1.8万股 | $13.9万 | 1.8万股 | 00.00% | 持仓不变 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #40 | $31.8万 | 1.7万股 | $6.7万 | 8,657股 | +8,614股+99.50% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #55 | $31.0万 | 1.7万股 | $9.8万 | 1.3万股 | +4,202股+33.16% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #60 | $28.7万 | 1.6万股 | $4.3万 | 5,619股 | +9,975股+177.52% | 加仓 |
| Avalon Trust Co |
| 0.02% | 0.01% | #17 | $25.7万 | 1.4万股 | $10.8万 | 1.4万股 | 00.00% | 持仓不变 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #68 | $25.4万 | 1.4万股 | $9.4万 | 1.2万股 | +1,757股+14.58% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #74 | $21.8万 | 1.2万股 | $11.5万 | 1.5万股 | -2,977股-20.05% | 减仓 |
| Schonfeld战略顾问Schonfeld Strategic Advisors LLC |
| <0.01% | — | #27 | $21.6万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| 大都会人寿投资管理MetLife Investment Management, LLC |
| <0.01% | — | #25 | $17.8万 | 9,652股 | $0 | 0股 | +9,652股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #80 | $14.8万 | 8,061股 | $5.9万 | 7,568股 | +493股+6.51% | 加仓 |
