| MPM BioImpact LLC |
| 3.67% | 8.41% | #1 | $6,012.7万 | 366.6万股 | $1.09亿 | 521.3万股 | -154.7万股-29.68% | 减仓 |
| Siren, L.L.C. |
| 0.62% | 1.08% | #10 | $3,046.1万 | 185.7万股 | $3,880.0万 | 185.7万股 | 00.00% | 持仓不变 |
| Vivo Capital, LLC |
| 2.76% | 4.63% | #2 | $3,025.4万 | 184.5万股 | $5,572.6万 | 266.8万股 | -82.3万股-30.84% | 减仓 |
| 洞察顾问PERCEPTIVE ADVISORS LLC |
| 0.41% | 0.39% | #13 | $2,711.5万 | 165.3万股 | $2,014.6万 | 96.4万股 | +68.9万股+71.44% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.12% | 0.18% | #17 | $2,396.7万 | 146.1万股 | $3,052.9万 | 146.1万股 | 00.00% | 持仓不变 |
| 工匠合伙人Artisan Partners Limited Partnership |
| 0.04% | 0.07% | #23 | $2,251.5万 | 137.3万股 | $4,636.3万 | 221.9万股 | -84.7万股-38.14% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #32 | $2,154.0万 | 131.3万股 | $166.2万 | 8.0万股 | +123.4万股+1,551.36% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #41 | $1,566.0万 | 95.5万股 | $8.5万 | 8,464股 | +94.6万股+11,181.99% | 加仓 |
| Logos Global Management LP |
| 0.65% | — | #9 | $1,500.6万 | 91.5万股 | $0 | 0股 | +91.5万股 | 新买入 |
| Patient Square Capital LP |
| 2.31% | 2.57% | #3 | $1,491.5万 | 90.9万股 | $1,448.8万 | 69.4万股 | +21.6万股+31.14% | 加仓 |
| Octagon Capital Advisors LP |
| 0.85% | 1.33% | #8 | $941.7万 | 57.4万股 | $1,199.5万 | 57.4万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.4% | 1.25% | #14 | $866.4万 | 52.8万股 | $2,115.9万 | 101.3万股 | -48.5万股-47.84% | 减仓 |
| Ikarian Capital, LLC |
| 0.89% | 0.18% | #7 | $840.0万 | 52.5万股 | $219.9万 | 52.5万股 | 00.00% | 持仓不变 |
| Redmile Group, LLC |
| 0.45% | 0.68% | #12 | $673.1万 | 41.0万股 | $1,026.4万 | 49.1万股 | -8.1万股-16.47% | 减仓 |
| 杜肯家族办公室Duquesne Family Office LLC |
| 0.12% | 0.24% | #16 | $628.7万 | 38.3万股 | $800.8万 | 38.3万股 | 00.00% | 持仓不变 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #38 | $620.7万 | 37.8万股 | $483.4万 | 23.1万股 | +14.7万股+63.56% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #36 | $439.2万 | 26.8万股 | $666.3万 | 31.9万股 | -5.1万股-16.04% | 减仓 |
| Elmind Capital, LP |
| 1.09% | 1.57% | #5 | $434.6万 | 26.5万股 | $553.6万 | 26.5万股 | 00.00% | 持仓不变 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #48 | $367.2万 | 22.4万股 | $23.6万 | 1.1万股 | +21.3万股+1,884.18% | 加仓 |
| Ishara Investments LP |
| 2.19% | 2.03% | #4 | $302.6万 | 18.5万股 | $214.1万 | 10.3万股 | +8.2万股+80.00% | 加仓 |
| Yiheng Capital Management, L.P. |
| 1.03% | 1.54% | #6 | $279.0万 | 17.0万股 | $355.4万 | 17.0万股 | 00.00% | 持仓不变 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.04% | 0.04% | #22 | $268.0万 | 16.3万股 | $341.3万 | 16.3万股 | 00.00% | 持仓不变 |
| GREAT POINT PARTNERS LLC |
| 0.49% | — | #11 | $257.3万 | 15.7万股 | $0 | 0股 | +15.7万股 | 新买入 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | <0.01% | #30 | $248.0万 | 15.1万股 | $50.3万 | 2.4万股 | +12.7万股+527.76% | 加仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | <0.01% | #33 | $195.7万 | 11.9万股 | $351.3万 | 16.8万股 | -4.9万股-29.04% | 减仓 |
| Envestnet资产管理ENVESTNET ASSET MANAGEMENT INC |
| <0.01% | <0.01% | #45 | $186.7万 | 11.4万股 | $199.9万 | 9.6万股 | +1.8万股+18.92% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | 0.02% | #25 | $149.6万 | 9.1万股 | $87.9万 | 4.2万股 | +4.9万股+116.86% | 加仓 |
| 罗素投资集团Russell Investments Group, Ltd. |
| <0.01% | <0.01% | #39 | $138.1万 | 8.4万股 | $268.6万 | 12.9万股 | -4.4万股-34.51% | 减仓 |
| 多元化财富管理DIVERSIFY WEALTH MANAGEMENT, LLC |
| 0.01% | 0.02% | #26 | $124.7万 | 9.0万股 | $129.3万 | 6.4万股 | +2.6万股+40.87% | 加仓 |
| Dorsey Wright & Associates |
| 0.2% | 0.27% | #15 | $119.9万 | 7.3万股 | $214.2万 | 10.3万股 | -2.9万股-28.70% | 减仓 |
| Polymer Capital Management (HK) LTD |
| 0.05% | 0.12% | #21 | $105.8万 | 6.5万股 | $134.7万 | 6.5万股 | 00.00% | 持仓不变 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #49 | $97.2万 | 5.9万股 | $0 | 0股 | +5.9万股 | 新买入 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #51 | $88.2万 | 5.4万股 | $116.7万 | 5.6万股 | -2,120股-3.79% | 减仓 |
| AdvisorShares Investments LLC |
| 0.09% | 0.19% | #19 | $71.6万 | 4.4万股 | $105.2万 | 5.0万股 | -6,677股-13.26% | 减仓 |
| Cetera投资顾问Cetera Investment Advisers |
| <0.01% | <0.01% | #44 | $57.8万 | 3.5万股 | $53.0万 | 2.5万股 | +9,899股+39.04% | 加仓 |
| 工程师之门Engineers Gate Manager LP |
| 0.01% | 0.01% | #29 | $53.2万 | 3.2万股 | $69.0万 | 3.3万股 | -601股-1.82% | 减仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #46 | $47.2万 | 2.9万股 | $78.2万 | 3.7万股 | -8,622股-23.04% | 减仓 |
| Stifel金融STIFEL FINANCIAL CORP |
| <0.01% | <0.01% | #47 | $45.3万 | 2.8万股 | $64.2万 | 3.1万股 | -3,128股-10.18% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #61 | $37.4万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| Burns Matteson Capital Management, LLC |
| 0.11% | 0.17% | #18 | $35.8万 | 2.2万股 | $47.3万 | 2.3万股 | -813股-3.59% | 减仓 |
| Atria投资Atria Investments, Inc |
| <0.01% | <0.01% | #31 | $31.0万 | 1.9万股 | $44.2万 | 2.1万股 | -2,233股-10.57% | 减仓 |
| Persistent Asset Partners Ltd |
| 0.08% | 0.09% | #20 | $25.6万 | 1.6万股 | $23.8万 | 1.1万股 | +4,238股+37.20% | 加仓 |
| PERSONAL CFO SOLUTIONS, LLC |
| 0.03% | 0.04% | #24 | $21.2万 | 1.3万股 | $26.4万 | 1.3万股 | +297股+2.35% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #50 | $19.9万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #53 | $19.1万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | — | #71 | $19.0万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| SEI投资SEI INVESTMENTS CO |
| <0.01% | <0.01% | #52 | $17.7万 | 1.1万股 | $35.0万 | 1.7万股 | -5,955股-35.52% | 减仓 |
| Integrated Wealth ConceptsIntegrated Wealth Concepts LLC |
| <0.01% | <0.01% | #40 | $17.0万 | 1.0万股 | $22.1万 | 1.1万股 | -213股-2.01% | 减仓 |
| China Universal Asset Management Co., Ltd. |
| 0.01% | 0.01% | #28 | $13.1万 | 8,000股 | $10.4万 | 5,000股 | +3,000股+60.00% | 加仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #66 | $11.8万 | 7,198股 | $16.9万 | 8,079股 | -881股-10.90% | 减仓 |
