| 贝莱德BlackRock, Inc. |
| 0.03% | 0.02% | #182 | $17.12亿 | 2,009.4万股 | $10.91亿 | 1,654.8万股 | +354.6万股+21.43% | 加仓 |
| 普信投资管理T. Rowe Price Investment Management, Inc. |
| 1.05% | 0.8% | #35 | $15.95亿 | 1,871.8万股 | $11.55亿 | 1,752.4万股 | +119.5万股+6.82% | 加仓 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| 0.1% | 0.1% | #106 | $5.91亿 | 693.2万股 | $5.28亿 | 800.9万股 | -107.8万股-13.46% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| 0.03% | 0.02% | #178 | $5.72亿 | 671.2万股 | $3.85亿 | 584.4万股 | +86.8万股+14.85% | 加仓 |
| 道富集团STATE STREET CORP |
| 0.02% | 0.01% | #213 | $5.53亿 | 649.4万股 | $3.79亿 | 574.5万股 | +74.9万股+13.04% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| 0.01% | 0.01% | #243 | $5.21亿 | 611.8万股 | $3.62亿 | 548.9万股 | +62.9万股+11.46% | 加仓 |
| 富达投资FMR LLC |
| 0.02% | 0.04% | #205 | $4.29亿 | 503.2万股 | $7.07亿 | 1,072.3万股 | -569.1万股-53.08% | 减仓 |
| Avoro资本顾问Avoro Capital Advisors LLC |
| 3.82% | 2.16% | #10 | $4.26亿 | 500.0万股 | $2.20亿 | 333.3万股 | +166.7万股+50.00% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| 0.03% | 0.01% | #181 | $3.95亿 | 463.6万股 | $2.06亿 | 312.5万股 | +151.0万股+48.32% | 加仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| 0.02% | 0.02% | #185 | $3.18亿 | 373.0万股 | $1.47亿 | 222.3万股 | +150.7万股+67.79% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| 0.02% | 0.01% | #211 | $3.16亿 | 371.3万股 | $2.12亿 | 321.5万股 | +49.7万股+15.46% | 加仓 |
| RTW投资RTW INVESTMENTS, LP |
| 2.08% | 1.78% | #21 | $2.44亿 | 286.2万股 | $1.79亿 | 272.1万股 | +14.1万股+5.18% | 加仓 |
| 停战资本ARMISTICE CAPITAL, LLC |
| 2.85% | 3.12% | #14 | $2.33亿 | 273.1万股 | $1.76亿 | 266.5万股 | +6.7万股+2.51% | 加仓 |
| 极地资本控股Polar Capital Holdings Plc |
| 0.45% | 0.39% | #54 | $1.92亿 | 225.4万股 | $1.09亿 | 166.1万股 | +59.2万股+35.66% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| 0.02% | 0.02% | #203 | $1.68亿 | 196.7万股 | $1.02亿 | 155.4万股 | +41.2万股+26.53% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| 0.02% | 0.01% | #212 | $1.67亿 | 195.9万股 | $1.04亿 | 158.4万股 | +37.5万股+23.65% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| 0.01% | 0.02% | #229 | $1.53亿 | 179.5万股 | $1.62亿 | 245.6万股 | -66.1万股-26.92% | 减仓 |
| 资本研究全球投资者Capital Research Global Investors |
| 0.02% | 0.01% | #196 | $1.44亿 | 168.7万股 | $5,081.7万 | 77.1万股 | +91.6万股+118.76% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| 0.02% | 0.01% | #214 | $1.40亿 | 164.7万股 | $9,501.8万 | 144.2万股 | +20.6万股+14.27% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| 0.01% | <0.01% | #281 | $1.39亿 | 158.9万股 | $5,691.3万 | 90.4万股 | +68.5万股+75.80% | 加仓 |
| 威廉·布莱尔投资管理WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC |
| 0.41% | 0.24% | #59 | $1.37亿 | 160.3万股 | $7,168.3万 | 108.8万股 | +51.6万股+47.43% | 加仓 |
| Integral Health 资产管理Integral Health Asset Management, LLC |
| 5.38% | 8.2% | #6 | $1.36亿 | 160.0万股 | $1.71亿 | 260.0万股 | -100.0万股-38.46% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.15% | 0.06% | #94 | $1.35亿 | 158.8万股 | $4,356.7万 | 66.1万股 | +92.7万股+140.29% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| 0.02% | 0.01% | #208 | $1.33亿 | 156.6万股 | $9,207.9万 | 139.7万股 | +16.9万股+12.08% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| 0.01% | 0.01% | #288 | $1.29亿 | 151.0万股 | $8,360.4万 | 152.1万股 | -1.1万股-0.71% | 减仓 |
| 信安金融集团PRINCIPAL FINANCIAL GROUP INC |
| 0.05% | 0.04% | #140 | $1.12亿 | 131.2万股 | $7,207.2万 | 109.3万股 | +21.8万股+19.95% | 加仓 |
| 资本国际投资者Capital International Investors |
| 0.02% | 0.02% | #189 | $1.11亿 | 130.6万股 | $8,824.1万 | 133.9万股 | -3.3万股-2.46% | 减仓 |
| 景顺Invesco Ltd. |
| 0.01% | <0.01% | #274 | $1.05亿 | 123.5万股 | $3,196.5万 | 48.5万股 | +75.0万股+154.72% | 加仓 |
| 瑞银集团UBS Group AG |
| 0.01% | 0.02% | #232 | $9,978.2万 | 117.1万股 | $1.39亿 | 210.2万股 | -93.1万股-44.28% | 减仓 |
| 百达资产管理Pictet Asset Management Holding SA |
| 0.09% | 0.05% | #109 | $9,903.8万 | 116.0万股 | $4,929.7万 | 75.1万股 | +41.0万股+54.53% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 2.15% | 1.97% | #17 | $9,881.0万 | 116.0万股 | $7,644.8万 | 116.0万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| 0.02% | 0.01% | #216 | $9,802.8万 | 115.1万股 | $6,631.8万 | 100.6万股 | +14.5万股+14.36% | 加仓 |
| Holocene顾问Holocene Advisors, LP |
| 0.22% | — | #78 | $9,750.7万 | 114.5万股 | $0 | 0股 | +114.5万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.29% | 0.25% | #72 | $9,376.9万 | 110.1万股 | $6,593.8万 | 100.0万股 | +10.0万股+10.02% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| 0.04% | 0.03% | #149 | $8,928.8万 | 104.8万股 | $4,925.7万 | 74.7万股 | +30.1万股+40.25% | 加仓 |
| 挪威央行投资管理NORGES BANK |
| 0.01% | 0.01% | #271 | $8,651.2万 | 101.6万股 | $4,730.0万 | 117.7万股 | -16.1万股-13.71% | 减仓 |
| Royalty Pharma Sub-Manager, LLC |
| 34.52% | 37.4% | #1 | $8,352.0万 | 98.0万股 | $6,461.8万 | 98.0万股 | 00.00% | 持仓不变 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| 0.12% | 0.01% | #100 | $8,193.7万 | 96.2万股 | $319.6万 | 4.8万股 | +91.3万股+1,883.82% | 加仓 |
| GW&K Investment Management, LLC |
| 0.61% | 0.29% | #48 | $7,804.3万 | 91.6万股 | $3,260.0万 | 49.5万股 | +42.1万股+85.21% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| 0.02% | 0.01% | #209 | $7,721.8万 | 90.6万股 | $5,270.3万 | 80.0万股 | +10.7万股+13.36% | 加仓 |
| 富兰克林资源FRANKLIN RESOURCES INC |
| 0.02% | 0.01% | #217 | $7,591.2万 | 89.1万股 | $2,700.9万 | 41.0万股 | +48.1万股+117.45% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| 0.01% | <0.01% | #299 | $7,288.7万 | 85.6万股 | $2,121.0万 | 32.2万股 | +53.4万股+165.88% | 加仓 |
| 法国巴黎银行资产管理BNP Paribas Asset Management Holding S.A. |
| 0.07% | — | #128 | $7,052.1万 | 82.8万股 | $0 | 0股 | +82.8万股 | 新买入 |
| Melqart Asset Management (UK) Ltd |
| 6.22% | 5.48% | #5 | $6,538.5万 | 76.8万股 | $5,562.5万 | 84.4万股 | -7.6万股-9.06% | 减仓 |
| Siren, L.L.C. |
| 1.31% | 1.12% | #30 | $6,465.5万 | 75.9万股 | $4,046.6万 | 61.4万股 | +14.5万股+23.62% | 加仓 |
| Group One交易GROUP ONE TRADING LLC |
| 0.09% | 0.05% | #116 | $6,402.0万 | 75.2万股 | $2,399.1万 | 36.4万股 | +38.8万股+106.46% | 加仓 |
| 费雪资产管理Fisher Asset Management, LLC |
| 0.02% | 0.02% | #204 | $6,335.6万 | 74.4万股 | $5,063.6万 | 76.8万股 | -2.5万股-3.20% | 减仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| 0.08% | 0.09% | #124 | $6,228.0万 | 73.1万股 | $7,237.9万 | 109.8万股 | -36.7万股-33.43% | 减仓 |
| Foresite Capital Management IV, LLC |
| 20.98% | 13.99% | #2 | $6,088.5万 | 71.5万股 | $3,317.2万 | 50.3万股 | +21.1万股+42.00% | 加仓 |
| 深轨资本Deep Track Capital, LP |
| 0.87% | 1.48% | #41 | $5,963.3万 | 70.0万股 | $9,058.1万 | 137.4万股 | -67.4万股-49.07% | 减仓 |
