| BVF INC/IL |
| 0.17% | 0.18% | #8 | $654.9万 | 111.0万股 | $555.0万 | 111.0万股 | 00.00% | 持仓不变 |
| Blue Owl Capital Holdings LP |
| 0.79% | 1.29% | #4 | $541.4万 | 91.8万股 | $479.7万 | 95.9万股 | -4.2万股-4.34% | 减仓 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.1% | 0.04% | #10 | $536.5万 | 90.9万股 | $189.3万 | 37.9万股 | +53.1万股+140.19% | 加仓 |
| Cable Car 资本Cable Car Capital, LP |
| 1.23% | 1.25% | #3 | $377.4万 | 75.5万股 | $377.4万 | 75.5万股 | 00.00% | 持仓不变 |
| Omega Fund Management, LLC |
| 1.45% | 1.4% | #2 | $268.7万 | 45.5万股 | $227.7万 | 45.5万股 | 00.00% | 持仓不变 |
| RTW投资RTW INVESTMENTS, LP |
| 0.02% | 0.02% | #14 | $197.3万 | 33.4万股 | $167.2万 | 33.4万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #23 | $189.1万 | 32.1万股 | $162.6万 | 32.5万股 | -4,637股-1.43% | 减仓 |
| Trails Edge Capital Partners, LP |
| 0.26% | — | #6 | $166.4万 | 28.2万股 | $0 | 0股 | +28.2万股 | 新买入 |
| BML Capital Management, LLC |
| 0.68% | 0.64% | #5 | $118.4万 | 20.1万股 | $100.4万 | 20.1万股 | 00.00% | 持仓不变 |
| Monashee Investment Management LLC |
| 1.9% | — | #1 | $113.5万 | 19.2万股 | $0 | 0股 | +19.2万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #28 | $79.7万 | 13.5万股 | $64.6万 | 12.9万股 | +5,876股+4.55% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.08% | — | #11 | $53.9万 | 9.6万股 | $0 | 0股 | +9.6万股 | 新买入 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #17 | $51.3万 | 8.7万股 | $40.8万 | 8.2万股 | +5,234股+6.41% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #18 | $39.3万 | 6.7万股 | $33.3万 | 6.7万股 | 00.00% | 持仓不变 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #24 | $32.8万 | 5.6万股 | $62.2万 | 12.4万股 | -6.9万股-55.28% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #26 | $31.6万 | 5.4万股 | $30.0万 | 6.0万股 | -6,417股-10.71% | 减仓 |
| NEA Management Company, LLC |
| 0.02% | 0.01% | #13 | $29.5万 | 5.0万股 | $25.0万 | 5.0万股 | 00.00% | 持仓不变 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.23% | 0.14% | #7 | $29.5万 | 5.0万股 | $15.0万 | 3.0万股 | +2.0万股+66.67% | 加仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #21 | $20.8万 | 3.4万股 | $16.6万 | 3.5万股 | -656股-1.88% | 减仓 |
| Sofinnova Investments, Inc. |
| 0.01% | 0.01% | #15 | $18.8万 | 3.2万股 | $15.9万 | 3.2万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #25 | $16.2万 | 2.7万股 | $13.6万 | 2.7万股 | +189股+0.69% | 加仓 |
| Rangeley Capital, LLC |
| 0.11% | 0.16% | #9 | $11.9万 | 2.0万股 | $16.3万 | 3.3万股 | -1.3万股-38.36% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #22 | $11.7万 | 2.0万股 | $0 | 0股 | +2.0万股 | 新买入 |
| Aldebaran Capital, LLC |
| 0.08% | 0.07% | #12 | $10.7万 | 1.8万股 | $9.3万 | 1.9万股 | -442股-2.38% | 减仓 |
| Shay Capital LLC |
| 0.01% | 0.01% | #16 | $10.7万 | 1.8万股 | $9.6万 | 1.9万股 | -1,050股-5.49% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #31 | $9.8万 | 1.7万股 | $1.0万 | 1,286股 | +1.5万股+1,196.89% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #29 | $9.1万 | 1.5万股 | $5.7万 | 1.1万股 | +4,027股+35.15% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #30 | $6.6万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #27 | $6.4万 | 1.1万股 | $5.5万 | 1.1万股 | -162股-1.48% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #32 | $4.1万 | 6,879股 | $2.7万 | 5,428股 | +1,451股+26.73% | 加仓 |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #20 | $3,983 | 675股 | $5,055 | 1,011股 | -336股-33.23% | 减仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #34 | $3,552 | 602股 | $3,010 | 602股 | 00.00% | 持仓不变 |
| Caitong International Asset Management Co., Ltd |
| <0.01% | <0.01% | #19 | $2,738 | 464股 | $10 | 2股 | +462股+23,100.00% | 加仓 |
| NewEdge顾问NewEdge Advisors, LLC |
| <0.01% | <0.01% | #33 | $944 | 160股 | $800 | 160股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #36 | $425 | 70股 | $1,465 | 293股 | -223股-76.11% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #35 | $142 | 24股 | $120 | 24股 | 00.00% | 持仓不变 |
