| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.02% | 0.02% | #7 | $101.5万 | 120.3万股 | $110.8万 | 60.6万股 | +59.8万股+98.71% | 加仓 |
| Ally Bridge Group (NY) LLC |
| 0.59% | — | #1 | $66.3万 | 78.6万股 | $0 | 0股 | +78.6万股 | 新买入 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #10 | $61.6万 | 73.0万股 | $133.6万 | 73.0万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.02% | #6 | $50.4万 | 59.8万股 | $28.2万 | 15.4万股 | +44.4万股+287.89% | 加仓 |
| Lynx1 Capital Management LP |
| 0.09% | <0.01% | #2 | $47.2万 | 55.9万股 | $2.8万 | 1.5万股 | +54.4万股+3,610.51% | 加仓 |
| Ikarian Capital, LLC |
| 0.04% | 0.1% | #5 | $40.3万 | 47.8万股 | $124.1万 | 67.8万股 | -20.0万股-29.49% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.04% | — | #4 | $33.6万 | 39.8万股 | $0 | 0股 | +39.8万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #21 | $27.8万 | 33.0万股 | $10.1万 | 5.5万股 | +27.5万股+497.99% | 加仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #18 | $18.2万 | 21.6万股 | $3.9万 | 2.1万股 | +19.5万股+916.93% | 加仓 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| <0.01% | — | #11 | $13.9万 | 16.4万股 | $0 | 0股 | +16.4万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | <0.01% | #9 | $11.3万 | 13.4万股 | $35.6万 | 19.5万股 | -6.1万股-31.15% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $9.4万 | 11.1万股 | $14.1万 | 7.7万股 | +3.4万股+44.44% | 加仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | — | #14 | $7.7万 | 9.1万股 | $0 | 0股 | +9.1万股 | 新买入 |
| Kynam Capital Management, LP |
| <0.01% | — | #8 | $7.1万 | 8.4万股 | $0 | 0股 | +8.4万股 | 新买入 |
| Dauntless Investment Group, LLC |
| 0.05% | 0.51% | #3 | $6.8万 | 8.1万股 | $76.3万 | 41.7万股 | -33.6万股-80.68% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #19 | $4.6万 | 5.5万股 | $5.8万 | 3.2万股 | +2.3万股+71.40% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | — | #23 | $3.2万 | 3.7万股 | $0 | 0股 | +3.7万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #25 | $2.2万 | 2.6万股 | $4.7万 | 2.6万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #13 | $1.5万 | 1.8万股 | $0 | 0股 | +1.8万股 | 新买入 |
| SG Americas Securities, LLC |
| <0.01% | — | #20 | $1.2万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| Virtu Financial LLC |
| <0.01% | — | #12 | $1.1万 | 1.3万股 | $0 | 0股 | +1.3万股 | 新买入 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #28 | $8,383 | 9,941股 | $1.8万 | 9,956股 | -15股-0.15% | 减仓 |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #15 | $4,336 | 5,142股 | $7,254 | 3,964股 | +1,178股+29.72% | 加仓 |
| 亨廷顿国民银行HUNTINGTON NATIONAL BANK |
| <0.01% | — | #17 | $3,943 | 4,676股 | $0 | 0股 | +4,676股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #26 | $2,909 | 3,451股 | $7,417 | 4,053股 | -602股-14.85% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #27 | $1,642 | 1,947股 | $0 | 0股 | +1,947股 | 新买入 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #16 | $1,451 | 1,721股 | $234 | 128股 | +1,593股+1,244.53% | 加仓 |
| 魁北克Desjardins联合会Federation des caisses Desjardins du Quebec |
| <0.01% | — | #24 | $414 | 500股 | $0 | 0股 | +500股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #31 | $395 | 468股 | $1,330 | 719股 | -251股-34.91% | 减仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #30 | $221 | 262股 | $479 | 262股 | 00.00% | 持仓不变 |
| 卡萨迪财富管理Cassaday & Co Wealth Management LLC |
| <0.01% | <0.01% | #29 | $6 | 6股 | $21 | 11股 | -5股-45.45% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #33 | $2 | 2股 | $42 | 23股 | -21股-91.30% | 减仓 |
| 琼斯金融JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #33 | $2 | 2股 | $4 | 2股 | 00.00% | 持仓不变 |
| Integrated Wealth ConceptsIntegrated Wealth Concepts LLC |
| <0.01% | — | #32 | $2 | 2股 | $0 | 0股 | +2股 | 新买入 |
