| 富兰克林资源FRANKLIN RESOURCES INC |
| <0.01% | <0.01% | #17 | $722.8万 | 93.9万股 | $530.5万 | 93.9万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.14% | 0.14% | #7 | $693.6万 | 89.2万股 | $502.2万 | 89.2万股 | 00.00% | 持仓不变 |
| Vivo Capital, LLC |
| 0.58% | 0.38% | #3 | $632.6万 | 81.4万股 | $458.1万 | 81.4万股 | 00.00% | 持仓不变 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #15 | $530.8万 | 68.3万股 | $388.9万 | 69.1万股 | -8,078股-1.17% | 减仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.66% | 0.44% | #2 | $507.4万 | 65.3万股 | $275.4万 | 48.9万股 | +16.3万股+33.40% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #13 | $389.1万 | 50.0万股 | $281.7万 | 50.0万股 | 00.00% | 持仓不变 |
| Stonepine Capital Management, LLC |
| 0.57% | 0.23% | #4 | $372.3万 | 49.2万股 | $56.3万 | 10.0万股 | +39.2万股+391.62% | 加仓 |
| 蒙塔诺瓦资本MONTANOVA CAPITAL, LLC |
| 0.07% | 0.07% | #12 | $369.3万 | 47.5万股 | $267.4万 | 47.5万股 | 00.00% | 持仓不变 |
| Avidity Partners Management LP |
| 0.48% | 0.44% | #5 | $301.5万 | 38.8万股 | $218.3万 | 38.8万股 | 00.00% | 持仓不变 |
| Saturn V Capital Management LP |
| 0.39% | 0.36% | #6 | $272.1万 | 35.0万股 | $197.1万 | 35.0万股 | 00.00% | 持仓不变 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.08% | 0.09% | #10 | $244.4万 | 31.4万股 | $233.3万 | 41.4万股 | -10.0万股-24.13% | 减仓 |
| 683 Capital Management, LLC |
| 0.09% | 0.07% | #9 | $179.5万 | 23.1万股 | $130.0万 | 23.1万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.08% | 0.07% | #11 | $173.1万 | 22.3万股 | $125.3万 | 22.3万股 | 00.00% | 持仓不变 |
| AWM Investment Company, Inc. |
| 0.12% | — | #8 | $140.0万 | 18.0万股 | $0 | 0股 | +18.0万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $118.8万 | 15.3万股 | $168.0万 | 29.8万股 | -14.6万股-48.81% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #16 | $116.6万 | 15.0万股 | $214.1万 | 38.0万股 | -23.0万股-60.56% | 减仓 |
| Empery Asset Management, LP |
| 0.96% | 1.56% | #1 | $83.3万 | 10.7万股 | $129.5万 | 23.0万股 | -12.3万股-53.46% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #19 | $52.7万 | 6.8万股 | $23.9万 | 4.2万股 | +2.5万股+59.41% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | — | #21 | $20.0万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| China Universal Asset Management Co., Ltd. |
| 0.01% | <0.01% | #14 | $15.6万 | 2.0万股 | $3.6万 | 6,400股 | +1.4万股+212.50% | 加仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #20 | $12.4万 | 1.6万股 | $9.1万 | 1.6万股 | -382股-2.35% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #22 | $9.3万 | 1.2万股 | $6.7万 | 1.2万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #24 | $6,073 | 781股 | $158 | 28股 | +753股+2,689.29% | 加仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #26 | $2,485 | 315股 | $0 | 0股 | +315股 | 新买入 |
| 魁北克Desjardins联合会Federation des caisses Desjardins du Quebec |
| <0.01% | <0.01% | #25 | $143 | 19股 | $106 | 19股 | 00.00% | 持仓不变 |
| Caitong International Asset Management Co., Ltd |
| <0.01% | <0.01% | #23 | $8 | 1股 | $6 | 1股 | 00.00% | 持仓不变 |
