| Vivo Capital, LLC |
| 1.39% | 0.9% | #4 | $1,526.4万 | 315.4万股 | $1,078.5万 | 315.4万股 | 00.00% | 持仓不变 |
| Commodore Capital LP |
| 0.85% | 0.46% | #5 | $1,419.9万 | 293.4万股 | $798.1万 | 233.4万股 | +60.0万股+25.71% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $1,122.2万 | 231.9万股 | $760.1万 | 222.3万股 | +9.6万股+4.33% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #34 | $806.1万 | 166.5万股 | $109.0万 | 31.9万股 | +134.7万股+422.48% | 加仓 |
| Spruce Street Capital LP |
| 1.58% | 1.34% | #3 | $804.0万 | 166.1万股 | $557.6万 | 166.1万股 | 00.00% | 持仓不变 |
| Almitas Capital LLC |
| 1.66% | 1.14% | #2 | $711.1万 | 146.9万股 | $505.9万 | 147.9万股 | -1.0万股-0.68% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #32 | $599.5万 | 123.9万股 | $345.8万 | 101.1万股 | +22.8万股+22.51% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #16 | $484.0万 | 100.0万股 | $342.0万 | 100.0万股 | 00.00% | 持仓不变 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #23 | $460.8万 | 95.2万股 | $53.1万 | 15.5万股 | +79.7万股+513.25% | 加仓 |
| Boxer Capital Management, LLC |
| 0.27% | 0.34% | #9 | $362.5万 | 74.9万股 | $256.2万 | 74.9万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #31 | $337.9万 | 69.8万股 | $98.1万 | 28.7万股 | +41.1万股+143.52% | 加仓 |
| SummitTX 资本SummitTX Capital, L.P. |
| 0.07% | — | #12 | $289.2万 | 59.7万股 | $0 | 0股 | +59.7万股 | 新买入 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | — | #20 | $269.1万 | 55.6万股 | $0 | 0股 | +55.6万股 | 新买入 |
| Stonepine Capital Management, LLC |
| 0.41% | 0.98% | #7 | $267.0万 | 55.2万股 | $244.1万 | 71.4万股 | -16.2万股-22.72% | 减仓 |
| 阿默普莱斯金融AMERIPRISE FINANCIAL INC |
| <0.01% | <0.01% | #24 | $259.9万 | 53.7万股 | $238.1万 | 69.6万股 | -15.9万股-22.86% | 减仓 |
| Sio Capital Management, LLC |
| 0.42% | 0.32% | #6 | $256.5万 | 53.0万股 | $224.8万 | 65.7万股 | -12.7万股-19.37% | 减仓 |
| Ally Bridge Group (NY) LLC |
| 2.25% | 1.45% | #1 | $254.7万 | 52.6万股 | $180.0万 | 52.6万股 | 00.00% | 持仓不变 |
| Prosight Management, LP |
| 0.4% | 0.29% | #8 | $229.7万 | 47.5万股 | $176.4万 | 51.6万股 | -4.1万股-7.97% | 减仓 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | 0.01% | #15 | $222.5万 | 46.0万股 | $339.8万 | 99.4万股 | -53.4万股-53.73% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #42 | $150.8万 | 31.2万股 | $39.4万 | 11.5万股 | +19.6万股+170.48% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #33 | $104.0万 | 21.5万股 | $14.8万 | 4.3万股 | +17.2万股+397.55% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.17% | 0.22% | #10 | $101.1万 | 20.9万股 | $68.3万 | 20.0万股 | +9,245股+4.63% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #29 | $95.3万 | 19.7万股 | $47.1万 | 13.8万股 | +5.9万股+43.00% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #46 | $86.9万 | 18.0万股 | $0 | 0股 | +18.0万股 | 新买入 |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
| 0.05% | 0.06% | #13 | $81.0万 | 16.7万股 | $102.0万 | 29.8万股 | -13.1万股-43.84% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #41 | $70.6万 | 14.6万股 | $134.6万 | 39.4万股 | -24.8万股-62.97% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #22 | $62.8万 | 13.0万股 | $68.0万 | 19.9万股 | -6.9万股-34.76% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | — | #47 | $42.6万 | 8.8万股 | $0 | 0股 | +8.8万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #37 | $36.8万 | 7.6万股 | $0 | 0股 | +7.6万股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #40 | $35.9万 | 7.4万股 | $21.0万 | 6.1万股 | +1.3万股+20.68% | 加仓 |
| Walleye资本Walleye Capital LLC |
| <0.01% | — | #21 | $34.9万 | 7.2万股 | $0 | 0股 | +7.2万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #39 | $32.8万 | 6.8万股 | $0 | 0股 | +6.8万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #43 | $31.1万 | 6.4万股 | $0 | 0股 | +6.4万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #18 | $29.0万 | 6.0万股 | $20.5万 | 6.0万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.01% | <0.01% | #14 | $28.5万 | 5.9万股 | $4.7万 | 1.4万股 | +4.5万股+324.27% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #56 | $23.9万 | 4.9万股 | $24.2万 | 19.1万股 | -14.1万股-74.12% | 减仓 |
| CAPTRUST金融顾问CAPTRUST FINANCIAL ADVISORS |
| <0.01% | <0.01% | #27 | $19.4万 | 4.0万股 | $13.7万 | 4.0万股 | +165股+0.41% | 加仓 |
| Velan Capital Investment Management LP |
| 0.12% | — | #11 | $19.4万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #44 | $17.1万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #48 | $12.5万 | 2.6万股 | $0 | 0股 | +2.6万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #35 | $11.8万 | 2.4万股 | $0 | 0股 | +2.4万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #53 | $10.8万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #57 | $10.7万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | — | #38 | $7.7万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 景顺Invesco Ltd. |
| <0.01% | — | #59 | $6.7万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| LPL金融LPL Financial LLC |
| <0.01% | — | #55 | $6.0万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #52 | $5.9万 | 1.2万股 | $6.5万 | 1.9万股 | -6,821股-35.73% | 减仓 |
| 未来资产环球ETFMIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. |
| <0.01% | — | #36 | $5.9万 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | — | #62 | $5.5万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| Bronte Capital Management Pty Ltd. |
| 0.01% | — | #17 | $5.3万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
