| EcoR1 Capital, LLC |
| 0.87% | 0.02% | #1 | $1,781.7万 | 155.2万股 | $47.1万 | 10.0万股 | +145.2万股+1,458.34% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | 0.01% | #4 | $975.8万 | 85.0万股 | $331.1万 | 70.0万股 | +15.0万股+21.43% | 加仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| 0.01% | <0.01% | #5 | $789.5万 | 68.8万股 | $91.9万 | 19.4万股 | +49.3万股+254.01% | 加仓 |
| Redmile Group, LLC |
| 0.34% | 0.14% | #2 | $507.1万 | 44.2万股 | $208.9万 | 44.2万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #15 | $283.6万 | 24.7万股 | $103.0万 | 21.8万股 | +2.9万股+13.40% | 加仓 |
| 麦肯齐金融MACKENZIE FINANCIAL CORP |
| <0.01% | <0.01% | #7 | $267.8万 | 23.3万股 | $148.3万 | 31.4万股 | -8.0万股-25.63% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #22 | $97.0万 | 8.4万股 | $37.4万 | 7.9万股 | +5,433股+6.88% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #17 | $86.3万 | 7.5万股 | $31.3万 | 6.6万股 | +8,982股+13.58% | 加仓 |
| STALEY CAPITAL ADVISERS INC |
| 0.02% | 0.01% | #3 | $57.4万 | 5.0万股 | $23.7万 | 5.0万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #14 | $49.4万 | 4.3万股 | $15.9万 | 3.4万股 | +9,415股+28.00% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #9 | $44.6万 | 3.9万股 | $61.7万 | 13.1万股 | -9.2万股-70.33% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #19 | $34.8万 | 3.0万股 | $16.0万 | 3.4万股 | -3,525股-10.41% | 减仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #24 | $30.4万 | 2.6万股 | $12.5万 | 2.6万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #21 | $19.0万 | 1.7万股 | $5.8万 | 1.2万股 | +4,251股+34.45% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #26 | $18.6万 | 1.6万股 | $7.7万 | 1.6万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #8 | $17.6万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #6 | $16.1万 | 1.4万股 | $15.5万 | 3.3万股 | -1.9万股-57.17% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #16 | $14.6万 | 1.3万股 | $22.6万 | 4.8万股 | -3.5万股-73.41% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #23 | $11.7万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #29 | $10.5万 | 9,178股 | $51.5万 | 3.6万股 | -2.7万股-74.46% | 减仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #25 | $5.5万 | 4,743股 | $2.0万 | 4,319股 | +424股+9.82% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #28 | $4.6万 | 3,979股 | $23.7万 | 5.0万股 | -4.6万股-92.05% | 减仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #27 | $1.7万 | 1,456股 | $6,887 | 1,456股 | 00.00% | 持仓不变 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #11 | $1.6万 | 1,404股 | $7,445 | 1,574股 | -170股-10.80% | 减仓 |
| 琼斯金融JONES FINANCIAL COMPANIES LLLP |
| <0.01% | <0.01% | #30 | $8,440 | 803股 | $3,227 | 703股 | +100股+14.22% | 加仓 |
| Caitong International Asset Management Co., Ltd |
| <0.01% | — | #10 | $3,570 | 311股 | $0 | 0股 | +311股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #31 | $3,490 | 304股 | $0 | 0股 | +304股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #32 | $2,881 | 251股 | $1,187 | 251股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #37 | $2,413 | 216股 | $933 | 216股 | 00.00% | 持仓不变 |
| 赖夫艾森国际银行Raiffeisen Bank International AG |
| <0.01% | <0.01% | #20 | $2,296 | 200股 | $946 | 200股 | 00.00% | 持仓不变 |
| Banque Transatlantique SA |
| <0.01% | <0.01% | #18 | $1,936 | 176股 | $906 | 176股 | 00.00% | 持仓不变 |
| 花旗集团CITIGROUP INC |
| <0.01% | <0.01% | #33 | $1,114 | 97股 | $5 | 1股 | +96股+9,600.00% | 加仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #34 | $528 | 46股 | $274 | 58股 | -12股-20.69% | 减仓 |
| PlanVest Financial, Inc |
| <0.01% | <0.01% | #13 | $321 | 28股 | $132 | 28股 | 00.00% | 持仓不变 |
| KERR FINANCIAL PLANNING Corp |
| <0.01% | <0.01% | #12 | $276 | 24股 | $116 | 24股 | 00.00% | 持仓不变 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #36 | $114 | 10股 | $47 | 10股 | 00.00% | 持仓不变 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #35 | $92 | 8股 | $38 | 8股 | 00.00% | 持仓不变 |
