| Squadron Capital Management LLC |
| 6.21% | 3.46% | #2 | $2,001.1万 | 412.6万股 | $943.3万 | 403.1万股 | +9.5万股+2.36% | 加仓 |
| 5AM Venture Management, LLC |
| 6.65% | 2.56% | #1 | $1,914.7万 | 394.8万股 | $923.8万 | 394.8万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #67 | $1,820.5万 | 375.4万股 | $297.1万 | 127.0万股 | +248.4万股+195.59% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #29 | $1,467.1万 | 302.5万股 | $691.8万 | 295.7万股 | +6.8万股+2.31% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #66 | $1,375.3万 | 283.6万股 | $540.7万 | 231.1万股 | +52.5万股+22.72% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.02% | 0.01% | #26 | $1,300.7万 | 268.2万股 | $665.8万 | 284.8万股 | -16.6万股-5.84% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #45 | $1,133.8万 | 233.8万股 | $411.0万 | 175.6万股 | +58.2万股+33.11% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #28 | $780.4万 | 160.9万股 | $453.5万 | 193.8万股 | -32.9万股-16.98% | 减仓 |
| Opaleye Management Inc. |
| 0.62% | 0.44% | #7 | $685.1万 | 141.3万股 | $330.6万 | 141.3万股 | 00.00% | 持仓不变 |
| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 0.13% | — | #13 | $674.4万 | 139.1万股 | $0 | 0股 | +139.1万股 | 新买入 |
| Decheng Capital LLC |
| 0.88% | 0.47% | #5 | $641.8万 | 132.3万股 | $309.7万 | 132.3万股 | 00.00% | 持仓不变 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #64 | $623.0万 | 128.4万股 | $145.4万 | 62.1万股 | +66.3万股+106.77% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #63 | $540.6万 | 111.5万股 | $265.0万 | 113.2万股 | -1.8万股-1.56% | 减仓 |
| Ishara Investments LP |
| 3.59% | 2.72% | #3 | $497.1万 | 102.5万股 | $287.8万 | 123.0万股 | -20.5万股-16.67% | 减仓 |
| PRIMECAP管理PRIMECAP MANAGEMENT CO/CA/ |
| <0.01% | <0.01% | #36 | $464.3万 | 95.7万股 | $224.0万 | 95.7万股 | 00.00% | 持仓不变 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.16% | — | #11 | $460.8万 | 95.0万股 | $0 | 0股 | +95.0万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #81 | $430.4万 | 88.7万股 | $58.4万 | 25.0万股 | +63.8万股+255.41% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #76 | $392.1万 | 80.9万股 | $84.4万 | 36.1万股 | +44.8万股+124.22% | 加仓 |
| PFIZER INC |
| 2.26% | 0.84% | #4 | $385.3万 | 95.4万股 | $200.3万 | 95.4万股 | 00.00% | 持仓不变 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| 0.01% | <0.01% | #32 | $367.6万 | 75.8万股 | $185.3万 | 79.2万股 | -3.4万股-4.29% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $322.2万 | 66.4万股 | $301.8万 | 129.0万股 | -62.6万股-48.50% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.15% | 0.02% | #12 | $316.6万 | 65.3万股 | $33.8万 | 14.5万股 | +50.8万股+351.31% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #40 | $286.9万 | 59.1万股 | $91.9万 | 39.3万股 | +19.9万股+50.64% | 加仓 |
| Qube研究科技Qube Research & Technologies Ltd |
| <0.01% | <0.01% | #37 | $278.8万 | 57.5万股 | $149.1万 | 63.7万股 | -6.2万股-9.78% | 减仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #46 | $265.1万 | 54.7万股 | $347.3万 | 148.4万股 | -93.8万股-63.17% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #58 | $263.0万 | 54.3万股 | $63.4万 | 27.2万股 | +27.1万股+99.55% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #82 | $228.6万 | 47.1万股 | $212.6万 | 140.8万股 | -93.7万股-66.53% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #70 | $188.3万 | 38.8万股 | $27.7万 | 11.8万股 | +27.0万股+228.55% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.11% | 0.09% | #16 | $181.5万 | 37.4万股 | $145.2万 | 62.0万股 | -24.6万股-39.68% | 减仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #77 | $180.7万 | 37.3万股 | $108.3万 | 46.3万股 | -9.0万股-19.48% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #62 | $163.4万 | 33.7万股 | $71.2万 | 30.4万股 | +3.2万股+10.66% | 加仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #94 | $150.5万 | 31.0万股 | $66.4万 | 28.4万股 | +2.6万股+9.28% | 加仓 |
| Seven Fleet Capital Management LP |
| 0.24% | 0.08% | #9 | $145.1万 | 31.8万股 | $25.7万 | 11.0万股 | +20.8万股+188.73% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #75 | $144.2万 | 29.7万股 | $36.4万 | 15.6万股 | +14.2万股+90.99% | 加仓 |
| XTX资本XTX Topco Ltd |
| 0.02% | 0.01% | #24 | $140.5万 | 29.0万股 | $75.5万 | 32.3万股 | -3.3万股-10.17% | 减仓 |
| Creative Planning财富管理Creative Planning |
| <0.01% | <0.01% | #50 | $138.2万 | 28.5万股 | $66.7万 | 28.5万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #86 | $130.5万 | 26.9万股 | $144.3万 | 61.7万股 | -34.8万股-56.37% | 减仓 |
| SEI投资SEI INVESTMENTS CO |
| <0.01% | <0.01% | #48 | $124.2万 | 25.6万股 | $44.8万 | 19.2万股 | +6.5万股+33.69% | 加仓 |
| Peapod Lane Capital LLC |
| 0.66% | 0.68% | #6 | $98.4万 | 20.3万股 | $83.5万 | 36.7万股 | -16.4万股-44.70% | 减仓 |
| CDC Financial, Inc. |
| 0.36% | 0.42% | #8 | $86.2万 | 17.8万股 | $66.4万 | 28.4万股 | -10.6万股-37.36% | 减仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #84 | $83.4万 | 17.2万股 | $12.0万 | 5.1万股 | +12.1万股+236.51% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #95 | $78.4万 | 16.2万股 | $29.4万 | 12.6万股 | +3.6万股+28.54% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.12% | 0.25% | #14 | $78.4万 | 16.2万股 | $63.0万 | 26.9万股 | -10.8万股-39.95% | 减仓 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #78 | $77.0万 | 15.9万股 | $138.3万 | 59.1万股 | -43.2万股-73.13% | 减仓 |
| Informed Momentum Co LLC |
| 0.05% | — | #19 | $61.5万 | 12.7万股 | $0 | 0股 | +12.7万股 | 新买入 |
| Quarry LP |
| 0.05% | 0.06% | #21 | $60.7万 | 12.5万股 | $35.1万 | 15.0万股 | -2.5万股-16.59% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #87 | $59.2万 | 12.2万股 | $0 | 0股 | +12.2万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #98 | $55.1万 | 11.4万股 | $114.7万 | 49.0万股 | -37.7万股-76.83% | 减仓 |
| 萨斯奎汉纳组合策略Susquehanna Portfolio Strategies, LLC |
| 0.01% | — | #31 | $54.4万 | 11.2万股 | $0 | 0股 | +11.2万股 | 新买入 |
| BARR E S & CO |
| 0.03% | 0.02% | #23 | $53.4万 | 11.0万股 | $25.7万 | 11.0万股 | 00.00% | 持仓不变 |
