| JOHNSON & JOHNSON |
| 2.59% | 5.84% | #1 | $2,068.8万 | 402.5万股 | $3,807.5万 | 402.5万股 | 00.00% | 持仓不变 |
| NEA Management Company, LLC |
| 0.63% | 1.09% | #3 | $1,004.6万 | 195.4万股 | $1,916.7万 | 202.6万股 | -7.2万股-3.54% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #42 | $640.2万 | 124.5万股 | $971.1万 | 102.7万股 | +21.9万股+21.32% | 加仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #19 | $633.8万 | 123.3万股 | $668.8万 | 70.7万股 | +52.6万股+74.45% | 加仓 |
| GSK plc |
| 0.86% | 1.59% | #2 | $517.9万 | 100.8万股 | $953.2万 | 100.8万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #41 | $468.0万 | 91.1万股 | $862.1万 | 91.1万股 | -734股-0.08% | 减仓 |
| Silvercrest资产管理集团SILVERCREST ASSET MANAGEMENT GROUP LLC |
| 0.03% | 0.04% | #6 | $451.3万 | 87.8万股 | $541.1万 | 57.2万股 | +30.6万股+53.51% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #39 | $226.6万 | 44.1万股 | $404.2万 | 42.7万股 | +1.4万股+3.21% | 加仓 |
| PFM Health Sciences, LP |
| 0.16% | — | #4 | $190.0万 | 37.0万股 | $0 | 0股 | +37.0万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #49 | $188.3万 | 36.6万股 | $331.6万 | 35.1万股 | +1.6万股+4.51% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #15 | $118.2万 | 23.0万股 | $18.3万 | 1.9万股 | +21.1万股+1,091.71% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #35 | $115.3万 | 22.4万股 | $98.2万 | 10.4万股 | +12.0万股+116.00% | 加仓 |
| 都铎投资TUDOR INVESTMENT CORP ET AL |
| <0.01% | <0.01% | #16 | $105.7万 | 20.6万股 | $186.7万 | 19.7万股 | +8,344股+4.23% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #46 | $76.8万 | 15.0万股 | $190.2万 | 20.1万股 | -5.2万股-25.62% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #55 | $74.5万 | 14.5万股 | $348.3万 | 43.2万股 | -28.7万股-66.41% | 减仓 |
| Kestra顾问服务Kestra Advisory Services, LLC |
| <0.01% | <0.01% | #13 | $68.1万 | 13.2万股 | $45.3万 | 4.8万股 | +8.5万股+176.41% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #21 | $68.1万 | 13.2万股 | $108.0万 | 11.4万股 | +1.8万股+15.97% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $66.3万 | 12.9万股 | $120.9万 | 12.8万股 | +1,194股+0.93% | 加仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #40 | $66.0万 | 12.8万股 | $49.7万 | 5.3万股 | +7.5万股+143.10% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #44 | $64.1万 | 12.5万股 | $142.0万 | 15.0万股 | -2.5万股-16.89% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #60 | $54.4万 | 10.6万股 | $89.7万 | 9.5万股 | +1.1万股+11.67% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $54.3万 | 10.6万股 | $85.0万 | 9.0万股 | +1.6万股+17.47% | 加仓 |
| Cresset资产管理Cresset Asset Management, LLC |
| <0.01% | <0.01% | #14 | $53.4万 | 10.4万股 | $100.6万 | 10.6万股 | -2,500股-2.35% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #29 | $50.0万 | 9.7万股 | $93.3万 | 9.9万股 | -1,361股-1.38% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #51 | $46.5万 | 9.0万股 | $57.8万 | 6.1万股 | +2.9万股+47.91% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | <0.01% | #20 | $42.3万 | 8.2万股 | $109.6万 | 11.6万股 | -3.3万股-28.91% | 减仓 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | — | #12 | $39.8万 | 7.8万股 | $0 | 0股 | +7.8万股 | 新买入 |
| GSA CAPITAL PARTNERS LLP |
| 0.02% | 0.03% | #7 | $25.9万 | 5.0万股 | $54.4万 | 5.8万股 | -7,180股-12.48% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #47 | $25.5万 | 5.0万股 | $40.4万 | 4.3万股 | +6,797股+15.90% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | 0.01% | #11 | $21.0万 | 4.1万股 | $51.1万 | 5.4万股 | -1.3万股-24.26% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #56 | $19.9万 | 3.9万股 | $36.5万 | 3.9万股 | +104股+0.27% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #61 | $18.2万 | 3.5万股 | $38.6万 | 4.1万股 | -5,423股-13.28% | 减仓 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #34 | $13.8万 | 2.7万股 | $0 | 0股 | +2.7万股 | 新买入 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #54 | $11.7万 | 2.3万股 | $12.5万 | 1.8万股 | +5,800股+33.03% | 加仓 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #17 | $11.2万 | 2.2万股 | $21.0万 | 2.2万股 | -404股-1.82% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #74 | $11.0万 | 1.9万股 | $6.0万 | 6,738股 | +1.2万股+174.67% | 加仓 |
| Jain GlobalJain Global LLC |
| <0.01% | — | #24 | $10.9万 | 2.1万股 | $0 | 0股 | +2.1万股 | 新买入 |
| 三菱UFJ资产管理Mitsubishi UFJ Asset Management Co., Ltd. |
| <0.01% | <0.01% | #48 | $10.7万 | 2.1万股 | $10.9万 | 1.1万股 | +9,233股+80.34% | 加仓 |
| RBF Capital, LLC |
| <0.01% | 0.01% | #10 | $10.3万 | 2.0万股 | $18.9万 | 2.0万股 | 00.00% | 持仓不变 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #72 | $10.2万 | 2.0万股 | $29.3万 | 3.1万股 | -1.1万股-35.87% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #45 | $9.7万 | 1.9万股 | $17.4万 | 1.8万股 | +433股+2.36% | 加仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #69 | $8.6万 | 1.7万股 | $8.1万 | 8,522股 | +8,170股+95.87% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #57 | $8.4万 | 1.6万股 | $12.9万 | 1.4万股 | +2,773股+20.30% | 加仓 |
| PHILADELPHIA TRUST CO |
| <0.01% | 0.01% | #9 | $7.7万 | 1.5万股 | $14.2万 | 1.5万股 | 00.00% | 持仓不变 |
| 格雷厄姆资本管理Graham Capital Management, L.P. |
| <0.01% | — | #18 | $7.7万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #75 | $6.9万 | 1.4万股 | $10.5万 | 1.1万股 | +2,400股+21.62% | 加仓 |
| R Squared Ltd |
| 0.04% | 0.05% | #5 | $6.9万 | 1.3万股 | $10.0万 | 1.1万股 | +2,855股+27.06% | 加仓 |
| Arax顾问Arax Advisory Partners |
| <0.01% | <0.01% | #23 | $6.8万 | 1.3万股 | $10.9万 | 1.1万股 | +1,693股+14.75% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #65 | $6.2万 | 1.2万股 | $32.3万 | 3.4万股 | -2.2万股-64.44% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #73 | $6.2万 | 1.2万股 | $11.5万 | 1.2万股 | 00.00% | 持仓不变 |
