| 富达投资FMR LLC |
| <0.01% | <0.01% | #25 | $5,581.9万 | 1,200.4万股 | $6,429.5万 | 1,195.1万股 | +5.3万股+0.45% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #43 | $4,054.8万 | 872.0万股 | $4,538.3万 | 843.5万股 | +28.5万股+3.37% | 加仓 |
| BML Capital Management, LLC |
| 18.44% | 24.38% | #1 | $3,232.8万 | 695.2万股 | $3,797.6万 | 705.9万股 | -10.6万股-1.51% | 减仓 |
| TANG CAPITAL MANAGEMENT LLC |
| 1.02% | 1.32% | #4 | $2,238.8万 | 481.5万股 | $2,590.3万 | 481.5万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #61 | $1,378.7万 | 296.5万股 | $1,746.4万 | 324.6万股 | -28.1万股-8.66% | 减仓 |
| Bain Capital Life Sciences Investors, LLC |
| 0.57% | 1.15% | #5 | $965.2万 | 207.6万股 | $1,270.0万 | 236.1万股 | -28.5万股-12.07% | 减仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| 0.01% | 0.01% | #13 | $946.4万 | 203.5万股 | $850.8万 | 158.3万股 | +45.2万股+28.58% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #47 | $910.9万 | 195.8万股 | $940.5万 | 174.8万股 | +21.1万股+12.06% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #63 | $768.4万 | 165.2万股 | $911.7万 | 169.5万股 | -4.2万股-2.49% | 减仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| 0.01% | 0.01% | #21 | $700.6万 | 150.7万股 | $1,002.9万 | 186.4万股 | -35.7万股-19.18% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #33 | $604.2万 | 130.0万股 | $675.3万 | 125.5万股 | +4.4万股+3.51% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| 0.01% | 0.01% | #19 | $526.0万 | 113.1万股 | $627.5万 | 116.6万股 | -3.5万股-3.02% | 减仓 |
| Rosalind Advisors, Inc. |
| 1.18% | 2.53% | #2 | $497.8万 | 107.1万股 | $630.5万 | 117.2万股 | -10.1万股-8.64% | 减仓 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #62 | $436.1万 | 94.6万股 | $477.6万 | 94.0万股 | +5,761股+0.61% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #52 | $351.2万 | 75.5万股 | $314.7万 | 58.5万股 | +17.0万股+29.10% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #68 | $334.6万 | 72.0万股 | $130.7万 | 45.1万股 | +26.9万股+59.69% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #77 | $293.0万 | 63.0万股 | $300.0万 | 55.8万股 | +7.3万股+13.02% | 加仓 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | <0.01% | #56 | $283.9万 | 61.1万股 | $321.0万 | 59.7万股 | +1.4万股+2.33% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #65 | $246.8万 | 53.1万股 | $316.6万 | 58.8万股 | -5.8万股-9.79% | 减仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #48 | $218.5万 | 47.0万股 | $260.8万 | 48.5万股 | -1.5万股-3.07% | 减仓 |
| CM Management, LLC |
| 1.05% | 1.6% | #3 | $165.1万 | 35.5万股 | $191.0万 | 35.5万股 | 00.00% | 持仓不变 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #60 | $162.1万 | 34.9万股 | $86.6万 | 16.1万股 | +18.8万股+116.63% | 加仓 |
| D.E.肖D. E. Shaw & Co., Inc. |
| <0.01% | <0.01% | #38 | $160.5万 | 34.5万股 | $204.1万 | 37.9万股 | -3.4万股-9.00% | 减仓 |
| 百达银行BANQUE PICTET & CIE SA |
| 0.01% | 0.01% | #15 | $160.5万 | 34.5万股 | $185.7万 | 34.5万股 | 00.00% | 持仓不变 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #49 | $141.6万 | 30.5万股 | $188.3万 | 35.0万股 | -4.5万股-12.95% | 减仓 |
| 纽文Nuveen, LLC |
| <0.01% | <0.01% | #59 | $132.2万 | 28.4万股 | $130.8万 | 24.3万股 | +4.1万股+16.94% | 加仓 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #81 | $124.2万 | 26.7万股 | $71.7万 | 13.3万股 | +13.4万股+100.32% | 加仓 |
| AQR资本管理AQR CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #54 | $115.2万 | 24.8万股 | $24.8万 | 4.6万股 | +20.2万股+437.23% | 加仓 |
| Quantinno资本管理Quantinno Capital Management LP |
| <0.01% | <0.01% | #31 | $112.7万 | 24.2万股 | $8.6万 | 1.6万股 | +22.6万股+1,419.13% | 加仓 |
| Opaleye Management Inc. |
| 0.1% | 0.23% | #11 | $109.3万 | 23.5万股 | $173.6万 | 32.3万股 | -8.8万股-27.15% | 减仓 |
| 汇丰控股HSBC HOLDINGS PLC |
| <0.01% | <0.01% | #51 | $102.3万 | 22.1万股 | $138.0万 | 25.9万股 | -3.8万股-14.66% | 减仓 |
| 箭街资本ARROWSTREET CAPITAL, LIMITED PARTNERSHIP |
| <0.01% | <0.01% | #50 | $97.9万 | 21.1万股 | $113.3万 | 21.1万股 | 00.00% | 持仓不变 |
| 惠灵顿管理集团WELLINGTON MANAGEMENT GROUP LLP |
| <0.01% | <0.01% | #71 | $96.2万 | 20.7万股 | $30.7万 | 5.7万股 | +15.0万股+262.72% | 加仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #74 | $88.1万 | 18.9万股 | $100.0万 | 18.6万股 | +3,647股+1.96% | 加仓 |
| Auour Investments LLC |
| 0.24% | 0.3% | #7 | $82.3万 | 17.7万股 | $95.2万 | 17.7万股 | 00.00% | 持仓不变 |
| 美国世纪投资AMERICAN CENTURY COMPANIES INC |
| <0.01% | <0.01% | #57 | $79.4万 | 17.1万股 | $90.0万 | 16.7万股 | +3,427股+2.05% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #86 | $73.1万 | 15.7万股 | $37.6万 | 7.0万股 | +8.7万股+125.25% | 加仓 |
| 联博ALLIANCEBERNSTEIN L.P. |
| <0.01% | <0.01% | #64 | $66.8万 | 12.4万股 | $43.3万 | 12.1万股 | +2,900股+2.39% | 加仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.02% | #14 | $60.9万 | 13.1万股 | $79.8万 | 14.8万股 | -1.8万股-11.79% | 减仓 |
| 威斯康星州投资委员会STATE OF WISCONSIN INVESTMENT BOARD |
| <0.01% | <0.01% | #32 | $55.2万 | 11.9万股 | $53.7万 | 10.0万股 | +1.9万股+18.99% | 加仓 |
| 俄亥俄州教师退休系统(STRS)STRS OHIO |
| <0.01% | <0.01% | #27 | $54.7万 | 11.8万股 | $51.9万 | 9.6万股 | +2.1万股+22.10% | 加仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | <0.01% | #96 | $53.9万 | 11.6万股 | $57.4万 | 10.7万股 | +9,246股+8.68% | 加仓 |
| 跳跃金融Jump Financial, LLC |
| <0.01% | 0.01% | #23 | $47.6万 | 10.2万股 | $50.2万 | 9.3万股 | +9,174股+9.84% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #94 | $43.9万 | 9.5万股 | $59.2万 | 11.0万股 | -1.5万股-14.05% | 减仓 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | <0.01% | #58 | $42.4万 | 9.1万股 | $47.9万 | 8.9万股 | +2,070股+2.32% | 加仓 |
| Aldebaran Capital, LLC |
| 0.31% | 0.37% | #6 | $41.0万 | 8.8万股 | $48.4万 | 9.0万股 | -1,766股-1.96% | 减仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #104 | $38.0万 | 8.2万股 | $56.8万 | 10.6万股 | -2.4万股-22.63% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #69 | $36.6万 | 7.9万股 | $84.1万 | 15.6万股 | -7.8万股-49.66% | 减仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | <0.01% | #83 | $32.7万 | 7.0万股 | $35.3万 | 6.6万股 | +4,714股+7.18% | 加仓 |
| 野村资产管理国际NOMURA ASSET MANAGEMENT INTERNATIONAL INC. |
| <0.01% | <0.01% | #46 | $32.6万 | 7.0万股 | $37.7万 | 7.0万股 | 00.00% | 持仓不变 |
