| Samsara BioCapital, LLC |
| 0.65% | 0.61% | #1 | $788.5万 | 1,036.9万股 | $624.6万 | 850.0万股 | +186.9万股+21.99% | 加仓 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.06% | 0.07% | #5 | $646.3万 | 850.0万股 | $624.6万 | 850.0万股 | 00.00% | 持仓不变 |
| AWM Investment Company, Inc. |
| 0.49% | 0.53% | #2 | $570.3万 | 750.0万股 | $477.6万 | 650.0万股 | +100.0万股+15.38% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #35 | $346.8万 | 456.3万股 | $339.8万 | 462.3万股 | -6.0万股-1.29% | 减仓 |
| Longaeva 合伙人Longaeva Partners L.P. |
| 0.04% | 0.06% | #6 | $177.1万 | 232.9万股 | $171.2万 | 232.9万股 | 00.00% | 持仓不变 |
| 极地资产管理Polar Asset Management Partners Inc. |
| 0.03% | — | #8 | $176.3万 | 231.9万股 | $0 | 0股 | +231.9万股 | 新买入 |
| Siren, L.L.C. |
| 0.03% | 0.04% | #7 | $152.1万 | 200.0万股 | $147.0万 | 200.0万股 | 00.00% | 持仓不变 |
| HEIGHTS CAPITAL MANAGEMENT, INC |
| 0.16% | — | #4 | $71.1万 | 93.5万股 | $0 | 0股 | +93.5万股 | 新买入 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $67.8万 | 89.1万股 | $66.4万 | 90.3万股 | -1.3万股-1.40% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #38 | $50.0万 | 65.8万股 | $20.3万 | 27.7万股 | +38.1万股+137.81% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | — | #26 | $44.6万 | 58.6万股 | $0 | 0股 | +58.6万股 | 新买入 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #42 | $37.8万 | 49.7万股 | $24.5万 | 33.4万股 | +16.3万股+48.92% | 加仓 |
| Nan Fung Group Holdings Ltd |
| 0.29% | 0.3% | #3 | $37.5万 | 49.4万股 | $36.3万 | 49.4万股 | 00.00% | 持仓不变 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #34 | $34.8万 | 45.8万股 | $33.4万 | 45.5万股 | +3,076股+0.68% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #25 | $32.8万 | 43.1万股 | $0 | 0股 | +43.1万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #50 | $28.4万 | 37.3万股 | $27.4万 | 37.3万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #54 | $26.0万 | 34.2万股 | $40.9万 | 55.7万股 | -21.5万股-38.57% | 减仓 |
| UNITED SERVICES AUTOMOBILE ASSOCIATION |
| 0.02% | 0.03% | #9 | $23.0万 | 30.3万股 | $22.2万 | 30.3万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #43 | $22.6万 | 29.7万股 | $16.7万 | 22.7万股 | +7.0万股+30.83% | 加仓 |
| Kestra私人财富KESTRA PRIVATE WEALTH SERVICES, LLC |
| <0.01% | <0.01% | #18 | $21.5万 | 28.2万股 | $19.5万 | 26.5万股 | +1.7万股+6.48% | 加仓 |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | <0.01% | #10 | $19.0万 | 25.0万股 | $7.1万 | 9.7万股 | +15.3万股+157.44% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #46 | $13.0万 | 17.0万股 | $12.5万 | 17.0万股 | 00.00% | 持仓不变 |
| CWA Asset Management 集团CWA Asset Management Group, LLC |
| <0.01% | <0.01% | #14 | $11.4万 | 15.0万股 | $11.0万 | 15.0万股 | 00.00% | 持仓不变 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #20 | $8.7万 | 11.5万股 | $8.4万 | 11.5万股 | 00.00% | 持仓不变 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #52 | $6.0万 | 7.9万股 | $105.1万 | 143.8万股 | -135.9万股-94.49% | 减仓 |
| King Luther资本管理KING LUTHER CAPITAL MANAGEMENT CORP |
| <0.01% | <0.01% | #29 | $4.4万 | 5.8万股 | $4.3万 | 5.8万股 | 00.00% | 持仓不变 |
| Well Done, LLC |
| 0.01% | 0.01% | #11 | $4.0万 | 5.2万股 | $3.8万 | 5.2万股 | 00.00% | 持仓不变 |
| Janney Montgomery Scott LLC |
| <0.01% | <0.01% | #37 | $3.7万 | 4.9万股 | $3.6万 | 4.9万股 | 00.00% | 持仓不变 |
| MOTCO |
| <0.01% | <0.01% | #17 | $3.7万 | 4.8万股 | $3.5万 | 4.8万股 | 00.00% | 持仓不变 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #41 | $3.2万 | 4.2万股 | $1.2万 | 1.6万股 | +2.6万股+155.48% | 加仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #48 | $2.4万 | 3.2万股 | $2.3万 | 3.2万股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $2.3万 | 3.0万股 | $3,374 | 6,750股 | +2.4万股+351.64% | 加仓 |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #24 | $2.3万 | 3.0万股 | $9,051 | 1.2万股 | +1.7万股+141.46% | 加仓 |
| Lafayette Investments, Inc. |
| <0.01% | <0.01% | #16 | $1.7万 | 2.3万股 | $1.7万 | 2.3万股 | 00.00% | 持仓不变 |
| TRAPHAGEN INVESTMENT ADVISORS LLC |
| <0.01% | <0.01% | #22 | $1.7万 | 2.2万股 | $1.6万 | 2.2万股 | 00.00% | 持仓不变 |
| 法伦资本FARALLON CAPITAL MANAGEMENT, L.L.C. |
| <0.01% | <0.01% | #36 | $1.6万 | 2.1万股 | $5.7万 | 7.8万股 | -5.7万股-73.46% | 减仓 |
| Cerity合伙人Cerity Partners LLC |
| <0.01% | <0.01% | #45 | $1.5万 | 1.9万股 | $1.4万 | 1.9万股 | 00.00% | 持仓不变 |
| 苏黎世州银行Zurcher Kantonalbank (Zurich Cantonalbank) |
| <0.01% | <0.01% | #44 | $1.4万 | 1.9万股 | $7,717 | 1.1万股 | +8,549股+81.40% | 加仓 |
| China Universal Asset Management Co., Ltd. |
| <0.01% | <0.01% | #23 | $1.4万 | 1.8万股 | $1.3万 | 1.7万股 | +576股+3.33% | 加仓 |
| J·萨夫拉·萨拉辛控股J. Safra Sarasin Holding AG |
| <0.01% | — | #28 | $1.3万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | — | #31 | $1.3万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #27 | $1.2万 | 1.6万股 | $1.1万 | 1.4万股 | +1,159股+8.08% | 加仓 |
| ACT Advisors, LLC. |
| <0.01% | <0.01% | #13 | $1.1万 | 1.5万股 | $1.1万 | 1.5万股 | 00.00% | 持仓不变 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | <0.01% | #58 | $1.1万 | 1.4万股 | $1.0万 | 1.4万股 | 00.00% | 持仓不变 |
| Farther金融顾问Farther Finance Advisors, LLC |
| <0.01% | <0.01% | #33 | $1.0万 | 1.4万股 | $1.1万 | 1.4万股 | 00.00% | 持仓不变 |
| CLEAR WAVE WEALTH MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $1.0万 | 1.3万股 | $9,720 | 1.3万股 | 00.00% | 持仓不变 |
| Disciplined Investors, L.L.C. |
| <0.01% | 0.01% | #12 | $9,277 | 1.2万股 | $8,965 | 1.2万股 | 00.00% | 持仓不变 |
| Sanctuary顾问Sanctuary Advisors, LLC |
| <0.01% | <0.01% | #39 | $9,135 | 1.2万股 | $8,828 | 1.2万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #62 | $8,927 | 1.2万股 | $8,690 | 1.2万股 | -86股-0.73% | 减仓 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| <0.01% | — | #47 | $8,779 | 1.2万股 | $0 | 0股 | +1.2万股 | 新买入 |
