| TANG CAPITAL MANAGEMENT LLC |
| 0.32% | 0.39% | #4 | $700.1万 | 614.1万股 | $774.0万 | 614.3万股 | -1,871股-0.03% | 减仓 |
| ADAR1 Capital Management, LLC |
| 0.29% | 0.19% | #6 | $628.1万 | 551.0万股 | $325.7万 | 258.5万股 | +292.5万股+113.13% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #47 | $278.2万 | 244.0万股 | $295.2万 | 234.3万股 | +9.7万股+4.15% | 加仓 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #29 | $275.5万 | 241.7万股 | $303.8万 | 241.7万股 | 00.00% | 持仓不变 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #32 | $258.0万 | 226.3万股 | $283.9万 | 225.3万股 | +9,694股+0.43% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #39 | $244.2万 | 214.2万股 | $411.2万 | 326.3万股 | -112.1万股-34.36% | 减仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #30 | $233.7万 | 205.0万股 | $233.5万 | 185.3万股 | +19.7万股+10.63% | 加仓 |
| Monaco Asset Management SAM |
| 0.18% | 0.45% | #10 | $221.0万 | 193.9万股 | $244.3万 | 193.9万股 | 00.00% | 持仓不变 |
| Lynx1 Capital Management LP |
| 0.4% | — | #3 | $205.0万 | 179.8万股 | $0 | 0股 | +179.8万股 | 新买入 |
| BML Capital Management, LLC |
| 1.01% | 1.25% | #2 | $176.3万 | 154.6万股 | $194.8万 | 154.6万股 | 00.00% | 持仓不变 |
| Prosight Management, LP |
| 0.27% | 0.34% | #7 | $156.2万 | 137.0万股 | $210.1万 | 166.8万股 | -29.7万股-17.83% | 减仓 |
| Peapod Lane Capital LLC |
| 1.01% | 1.3% | #1 | $149.2万 | 130.9万股 | $158.9万 | 128.9万股 | +2.0万股+1.59% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| <0.01% | 0.01% | #27 | $147.8万 | 129.7万股 | $210.0万 | 166.7万股 | -37.0万股-22.22% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #58 | $131.2万 | 115.1万股 | $138.2万 | 109.6万股 | +5.5万股+5.00% | 加仓 |
| Ikarian Capital, LLC |
| 0.12% | — | #11 | $114.0万 | 100.0万股 | $0 | 0股 | +100.0万股 | 新买入 |
| Eversept Partners, LP |
| 0.05% | 0.06% | #15 | $101.6万 | 89.1万股 | $112.3万 | 89.1万股 | 00.00% | 持仓不变 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #36 | $95.2万 | 83.5万股 | $125.5万 | 99.6万股 | -16.1万股-16.15% | 减仓 |
| Redmile Group, LLC |
| 0.06% | 0.06% | #14 | $88.0万 | 77.2万股 | $97.3万 | 77.2万股 | 00.00% | 持仓不变 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #52 | $78.4万 | 68.2万股 | $101.3万 | 86.2万股 | -18.0万股-20.91% | 减仓 |
| Jacobs Levy股票管理JACOBS LEVY EQUITY MANAGEMENT, INC |
| <0.01% | <0.01% | #31 | $73.3万 | 64.3万股 | $90.5万 | 71.9万股 | -7.5万股-10.50% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #53 | $66.0万 | 57.9万股 | $52.6万 | 41.7万股 | +16.1万股+38.66% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #45 | $65.2万 | 57.2万股 | $133.3万 | 105.8万股 | -48.6万股-45.96% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #40 | $63.8万 | 55.9万股 | $148.7万 | 118.1万股 | -62.1万股-52.61% | 减仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | 0.01% | #24 | $63.1万 | 55.4万股 | $69.8万 | 55.4万股 | 00.00% | 持仓不变 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #34 | $61.1万 | 53.6万股 | $65.2万 | 51.7万股 | +1.9万股+3.60% | 加仓 |
| BESSEMER GROUP INC |
| <0.01% | <0.01% | #35 | $60.7万 | 53.2万股 | $67.0万 | 53.2万股 | 00.00% | 持仓不变 |
| DAFNA Capital Management LLC |
| 0.11% | 0.14% | #12 | $55.5万 | 48.7万股 | $61.4万 | 48.7万股 | 00.00% | 持仓不变 |
| XTX资本XTX Topco Ltd |
| 0.01% | 0.01% | #25 | $50.3万 | 44.1万股 | $63.1万 | 50.1万股 | -6.0万股-11.98% | 减仓 |
| Laurion 资本管理Laurion Capital Management LP |
| 0.01% | 0.02% | #21 | $47.1万 | 41.3万股 | $52.0万 | 41.3万股 | 00.00% | 持仓不变 |
| TORNO 资本TORNO CAPITAL, LLC |
| 0.01% | 0.06% | #23 | $40.1万 | 35.1万股 | $44.1万 | 35.0万股 | +1,445股+0.41% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #44 | $39.0万 | 34.2万股 | $42.8万 | 34.0万股 | +2,211股+0.65% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | — | #26 | $34.5万 | 30.3万股 | $0 | 0股 | +30.3万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #60 | $34.1万 | 29.9万股 | $519.1万 | 350.7万股 | -320.8万股-91.48% | 减仓 |
| SEI投资SEI INVESTMENTS CO |
| <0.01% | <0.01% | #38 | $33.9万 | 29.7万股 | $37.5万 | 29.7万股 | 00.00% | 持仓不变 |
| Verdad Advisers, LP |
| 0.31% | 0.14% | #5 | $32.1万 | 28.1万股 | $12.4万 | 9.8万股 | +18.3万股+186.15% | 加仓 |
| ArrowMark Colorado Holdings LLC |
| 0.01% | 0.01% | #20 | $32.1万 | 28.1万股 | $35.4万 | 28.1万股 | 00.00% | 持仓不变 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.24% | 0.32% | #9 | $31.4万 | 27.5万股 | $34.7万 | 27.5万股 | 00.00% | 持仓不变 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #68 | $28.9万 | 25.3万股 | $31.9万 | 25.3万股 | 00.00% | 持仓不变 |
| Stonepine Capital Management, LLC |
| 0.04% | 0.11% | #17 | $26.3万 | 23.1万股 | $28.3万 | 22.5万股 | +5,888股+2.62% | 加仓 |
| Rangeley Capital, LLC |
| 0.24% | 0.28% | #8 | $25.7万 | 22.5万股 | $28.4万 | 22.5万股 | 00.00% | 持仓不变 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #56 | $23.8万 | 20.9万股 | $75.2万 | 59.7万股 | -38.8万股-65.05% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #59 | $23.3万 | 20.4万股 | $46.5万 | 36.9万股 | -16.5万股-44.77% | 减仓 |
| Marquette Asset Management, LLC |
| 0.03% | — | #19 | $19.9万 | 17.5万股 | $0 | 0股 | +17.5万股 | 新买入 |
| HighMark Wealth Management LLC |
| 0.06% | 0.09% | #13 | $18.9万 | 16.6万股 | $20.9万 | 16.6万股 | 00.00% | 持仓不变 |
| GSA CAPITAL PARTNERS LLP |
| 0.01% | 0.03% | #22 | $18.5万 | 16.2万股 | $50.7万 | 40.2万股 | -24.0万股-59.66% | 减仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | <0.01% | #70 | $17.5万 | 15.4万股 | $19.4万 | 15.4万股 | -98股-0.06% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #61 | $14.3万 | 12.5万股 | $19.4万 | 15.4万股 | -2.9万股-18.88% | 减仓 |
| Algert全球ALGERT GLOBAL LLC |
| <0.01% | <0.01% | #33 | $14.1万 | 12.3万股 | $10.6万 | 8.4万股 | +3.9万股+46.12% | 加仓 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #41 | $13.1万 | 11.5万股 | $14.5万 | 11.5万股 | 00.00% | 持仓不变 |
| 景顺Invesco Ltd. |
| <0.01% | <0.01% | #65 | $11.9万 | 10.5万股 | $14.5万 | 11.5万股 | -1.1万股-9.15% | 减仓 |
