| Samsara BioCapital, LLC |
| 4.31% | 7.26% | #1 | $5,242.6万 | 1,288.1万股 | $7,471.0万 | 1,294.8万股 | -6.7万股-0.52% | 减仓 |
| RTW投资RTW INVESTMENTS, LP |
| 0.05% | 0.07% | #6 | $529.1万 | 130.0万股 | $750.1万 | 130.0万股 | 00.00% | 持仓不变 |
| Alyeska投资集团Alyeska Investment Group, L.P. |
| 0.01% | 0.01% | #14 | $233.1万 | 57.3万股 | $327.5万 | 57.3万股 | 00.00% | 持仓不变 |
| Siren, L.L.C. |
| 0.04% | 0.07% | #9 | $177.4万 | 43.6万股 | $251.5万 | 43.6万股 | 00.00% | 持仓不变 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #39 | $162.3万 | 39.9万股 | $147.3万 | 25.5万股 | +14.3万股+56.14% | 加仓 |
| Ikarian Capital, LLC |
| 0.16% | 0.17% | #4 | $146.5万 | 36.0万股 | $207.7万 | 36.0万股 | 00.00% | 持仓不变 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #31 | $106.7万 | 26.2万股 | $3.6万 | 6,184股 | +25.6万股+4,138.86% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #23 | $60.8万 | 14.9万股 | $38.2万 | 6.6万股 | +8.3万股+125.77% | 加仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #26 | $56.7万 | 13.9万股 | $39.2万 | 6.8万股 | +7.1万股+105.07% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #40 | $46.4万 | 11.4万股 | $50.5万 | 8.8万股 | +2.6万股+30.26% | 加仓 |
| Woodline合伙人Woodline Partners LP |
| <0.01% | <0.01% | #21 | $40.7万 | 10.0万股 | $57.7万 | 10.0万股 | 00.00% | 持仓不变 |
| ADAR1 Capital Management, LLC |
| 0.02% | 0.03% | #10 | $40.7万 | 10.0万股 | $57.7万 | 10.0万股 | 00.00% | 持仓不变 |
| WHI TRUST Co LLC |
| 0.26% | 0.42% | #3 | $39.7万 | 9.7万股 | $56.3万 | 9.7万股 | 00.00% | 持仓不变 |
| 雷蒙德詹姆斯金融RAYMOND JAMES FINANCIAL INC |
| <0.01% | <0.01% | #32 | $39.5万 | 9.7万股 | $68.6万 | 11.9万股 | -2.2万股-18.27% | 减仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | — | #38 | $39.0万 | 9.6万股 | $0 | 0股 | +9.6万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #16 | $37.6万 | 9.2万股 | $53.2万 | 9.2万股 | 00.00% | 持仓不变 |
| Verdad Advisers, LP |
| 0.31% | — | #2 | $32.7万 | 8.0万股 | $0 | 0股 | +8.0万股 | 新买入 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #41 | $29.4万 | 7.2万股 | $14.4万 | 2.5万股 | +4.7万股+190.26% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #36 | $26.9万 | 6.6万股 | $21.2万 | 3.7万股 | +2.9万股+80.24% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #47 | $22.2万 | 5.4万股 | $20.8万 | 3.6万股 | +1.8万股+51.05% | 加仓 |
| Belpointe 资产管理Belpointe Asset Management LLC |
| 0.01% | 0.01% | #15 | $16.3万 | 4.0万股 | $23.1万 | 4.0万股 | 00.00% | 持仓不变 |
| Fortis Capital Advisors, LLC |
| 0.02% | 0.03% | #12 | $16.3万 | 4.0万股 | $23.1万 | 4.0万股 | 00.00% | 持仓不变 |
| Pale Fire Capital SE |
| 0.01% | — | #13 | $16.1万 | 4.0万股 | $0 | 0股 | +4.0万股 | 新买入 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | <0.01% | #30 | $15.8万 | 3.9万股 | $22.9万 | 4.0万股 | -998股-2.51% | 减仓 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #18 | $13.2万 | 3.3万股 | $13.0万 | 2.3万股 | +1.0万股+44.44% | 加仓 |
| Stonepine Capital Management, LLC |
| 0.02% | 0.05% | #11 | $12.3万 | 3.0万股 | $11.8万 | 2.0万股 | +9,722股+47.66% | 加仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #29 | $12.2万 | 3.0万股 | $7.9万 | 1.4万股 | +1.6万股+119.75% | 加仓 |
| Trexquant投资Trexquant Investment LP |
| <0.01% | — | #24 | $12.1万 | 3.0万股 | $0 | 0股 | +3.0万股 | 新买入 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #48 | $10.8万 | 2.7万股 | $15.3万 | 2.7万股 | 00.00% | 持仓不变 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #42 | $10.5万 | 2.6万股 | $8.3万 | 1.4万股 | +1.1万股+78.83% | 加仓 |
| Velan Capital Investment Management LP |
| 0.06% | 0.07% | #5 | $10.2万 | 2.5万股 | $10.4万 | 1.8万股 | +7,000股+38.89% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #35 | $9.7万 | 2.4万股 | $17.7万 | 3.1万股 | -6,803股-22.20% | 减仓 |
| WealthTrust Asset Management, LLC |
| 0.04% | 0.04% | #7 | $8.3万 | 2.0万股 | $7.2万 | 1.2万股 | +8,000股+64.43% | 加仓 |
| Independent Advisor Alliance |
| <0.01% | <0.01% | #19 | $7.4万 | 1.8万股 | $8.2万 | 1.4万股 | +3,895股+27.37% | 加仓 |
| RBF Capital, LLC |
| <0.01% | <0.01% | #17 | $7.1万 | 1.7万股 | $10.0万 | 1.7万股 | 00.00% | 持仓不变 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | — | #25 | $6.7万 | 1.7万股 | $0 | 0股 | +1.7万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #44 | $6.5万 | 1.6万股 | $63.8万 | 11.1万股 | -9.4万股-85.47% | 减仓 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | — | #43 | $6.5万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #45 | $5.8万 | 1.4万股 | $30.4万 | 5.3万股 | -3.8万股-73.01% | 减仓 |
| HRT金融HRT FINANCIAL LP |
| <0.01% | <0.01% | #33 | $5.6万 | 1.4万股 | $6.7万 | 1.2万股 | +2,106股+18.13% | 加仓 |
| NANO CAP NEW MILLENNIUM GROWTH FUND L P |
| 0.04% | 0.02% | #8 | $5.1万 | 1.3万股 | $2.3万 | 4,000股 | +8,500股+212.50% | 加仓 |
| Virtu Financial LLC |
| <0.01% | — | #20 | $4.4万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| Sigma Planning Corp |
| <0.01% | — | #22 | $4.1万 | 1.0万股 | $0 | 0股 | +1.0万股 | 新买入 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #50 | $3.2万 | 7,806股 | $4.5万 | 7,806股 | 00.00% | 持仓不变 |
| Integrated Wealth ConceptsIntegrated Wealth Concepts LLC |
| <0.01% | — | #34 | $2.0万 | 5,000股 | $0 | 0股 | +5,000股 | 新买入 |
| Tower Research Capital LLC (TRC) |
| <0.01% | <0.01% | #27 | $1.0万 | 2,560股 | $802 | 139股 | +2,421股+1,741.73% | 加仓 |
| Steward合伙人投资顾问Steward Partners Investment Advisory, LLC |
| <0.01% | <0.01% | #37 | $9,015 | 2,215股 | $1.3万 | 2,215股 | 00.00% | 持仓不变 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #51 | $2,951 | 725股 | $4,183 | 725股 | 00.00% | 持仓不变 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #54 | $1,233 | 303股 | $3.0万 | 5,280股 | -4,977股-94.26% | 减仓 |
| Strengthening Families & Communities, LLC |
| <0.01% | <0.01% | #28 | $1,091 | 268股 | $1,546 | 268股 | 00.00% | 持仓不变 |
