| Affinity Asset Advisors, LLC |
| 0.32% | 0.3% | #5 | $701.4万 | 400.8万股 | $590.4万 | 310.7万股 | +90.1万股+28.99% | 加仓 |
| Cormorant Asset Management, LP |
| 0.32% | — | #4 | $624.8万 | 357.0万股 | $0 | 0股 | +357.0万股 | 新买入 |
| SILVERARC CAPITAL MANAGEMENT, LLC |
| 0.64% | 0.04% | #1 | $616.1万 | 352.0万股 | $42.9万 | 22.6万股 | +329.4万股+1,457.74% | 加仓 |
| Vestal Point 资本Vestal Point Capital, LP |
| 0.11% | — | #8 | $455.0万 | 260.0万股 | $0 | 0股 | +260.0万股 | 新买入 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $367.2万 | 209.8万股 | $206.8万 | 108.8万股 | +101.0万股+92.79% | 加仓 |
| Frazier Life Sciences 管理Frazier Life Sciences Management, L.P. |
| 0.07% | 0.1% | #10 | $341.9万 | 195.3万股 | $371.2万 | 195.3万股 | 00.00% | 持仓不变 |
| Ensign Peak顾问Ensign Peak Advisors, Inc |
| 0.01% | — | #19 | $320.7万 | 183.2万股 | $0 | 0股 | +183.2万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.01% | — | #16 | $310.9万 | 177.7万股 | $0 | 0股 | +177.7万股 | 新买入 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #25 | $289.0万 | 165.1万股 | $294.5万 | 155.0万股 | +10.2万股+6.56% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #29 | $242.2万 | 138.4万股 | $181.7万 | 95.6万股 | +42.8万股+44.71% | 加仓 |
| Balyasny资产管理BALYASNY ASSET MANAGEMENT L.P. |
| <0.01% | <0.01% | #21 | $204.9万 | 117.1万股 | $192.1万 | 101.1万股 | +16.0万股+15.82% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #31 | $196.3万 | 112.1万股 | $55.2万 | 29.0万股 | +83.1万股+286.17% | 加仓 |
| Ikarian Capital, LLC |
| 0.18% | 0.15% | #7 | $167.5万 | 95.7万股 | $181.8万 | 95.7万股 | 00.00% | 持仓不变 |
| Sio Capital Management, LLC |
| 0.26% | 0.25% | #6 | $158.2万 | 90.4万股 | $171.8万 | 90.4万股 | 00.00% | 持仓不变 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #24 | $158.2万 | 90.4万股 | $117.9万 | 62.1万股 | +28.4万股+45.69% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $87.7万 | 50.1万股 | $73.7万 | 38.8万股 | +11.3万股+29.22% | 加仓 |
| Walleye资本Walleye Capital LLC |
| <0.01% | <0.01% | #20 | $87.6万 | 50.0万股 | $73.8万 | 38.9万股 | +11.2万股+28.78% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #26 | $87.3万 | 49.9万股 | $0 | 0股 | +49.9万股 | 新买入 |
| NOESIS CAPITAL MANGEMENT CORP |
| 0.09% | 0.09% | #9 | $70.9万 | 40.5万股 | $59.2万 | 31.2万股 | +9.4万股+30.02% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #27 | $70.1万 | 40.1万股 | $77.7万 | 40.9万股 | -8,191股-2.00% | 减仓 |
| Ally Bridge Group (NY) LLC |
| 0.6% | — | #2 | $68.3万 | 39.0万股 | $0 | 0股 | +39.0万股 | 新买入 |
| ADAR1 Capital Management, LLC |
| 0.03% | 0.05% | #13 | $65.7万 | 37.6万股 | $89.3万 | 47.0万股 | -9.4万股-20.08% | 减仓 |
| Verdad Advisers, LP |
| 0.5% | 0.12% | #3 | $52.3万 | 29.9万股 | $10.7万 | 5.6万股 | +24.3万股+430.78% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #32 | $50.2万 | 28.7万股 | $39.0万 | 20.5万股 | +8.2万股+39.93% | 加仓 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| 0.01% | 0.01% | #18 | $44.5万 | 25.4万股 | $48.3万 | 25.4万股 | 00.00% | 持仓不变 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #39 | $42.4万 | 24.2万股 | $24.9万 | 13.1万股 | +11.1万股+84.44% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | — | #28 | $35.5万 | 20.3万股 | $0 | 0股 | +20.3万股 | 新买入 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #35 | $35.1万 | 20.0万股 | $38.0万 | 20.0万股 | +243股+0.12% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #37 | $29.9万 | 17.1万股 | $26.8万 | 14.1万股 | +3.0万股+20.96% | 加仓 |
| DAFNA Capital Management LLC |
| 0.06% | 0.08% | #11 | $29.8万 | 17.0万股 | $36.8万 | 19.4万股 | -2.4万股-12.18% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #36 | $19.5万 | 11.1万股 | $14.7万 | 7.7万股 | +3.4万股+43.96% | 加仓 |
| Atom Investors LP |
| 0.02% | — | #14 | $17.8万 | 10.2万股 | $0 | 0股 | +10.2万股 | 新买入 |
| XTX资本XTX Topco Ltd |
| <0.01% | <0.01% | #23 | $10.1万 | 5.8万股 | $11.9万 | 6.2万股 | -4,609股-7.38% | 减仓 |
| Headlands Technologies LLC |
| 0.01% | <0.01% | #17 | $8.3万 | 4.7万股 | $2.1万 | 1.1万股 | +3.6万股+333.00% | 加仓 |
| TWO SIGMA SECURITIES, LLC |
| <0.01% | — | #22 | $2.8万 | 1.6万股 | $0 | 0股 | +1.6万股 | 新买入 |
| Innovative Asset Advisors Group, LLC |
| 0.01% | — | #15 | $2.6万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| Spark Investment Management LLC |
| 0.05% | — | #12 | $2.4万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #41 | $1.9万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| 摩根大通JPMORGAN CHASE & CO |
| <0.01% | <0.01% | #49 | $1.0万 | 5,897股 | $3 | 2股 | +5,895股+294,750.00% | 加仓 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #40 | $9,555 | 5,460股 | $1.0万 | 5,460股 | 00.00% | 持仓不变 |
| 巴克莱BARCLAYS PLC |
| <0.01% | — | #46 | $5,696 | 3,255股 | $0 | 0股 | +3,255股 | 新买入 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #50 | $877 | 501股 | $4,129 | 2,173股 | -1,672股-76.94% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | — | #51 | $757 | 433股 | $0 | 0股 | +433股 | 新买入 |
| Fortitude Family Office, LLC |
| <0.01% | <0.01% | #30 | $754 | 431股 | $1,212 | 638股 | -207股-32.45% | 减仓 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #47 | $665 | 380股 | $1,110 | 584股 | -204股-34.93% | 减仓 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | <0.01% | #52 | $177 | 101股 | $2 | 1股 | +100股+10,000.00% | 加仓 |
| SHP Wealth Management |
| <0.01% | <0.01% | #38 | $105 | 60股 | $114 | 60股 | 00.00% | 持仓不变 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #44 | $74 | 42股 | $42 | 22股 | +20股+90.91% | 加仓 |
| SOA Wealth Advisors, LLC. |
| <0.01% | <0.01% | #43 | $23 | 13股 | $25 | 13股 | 00.00% | 持仓不变 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #55 | $18 | 10股 | $47 | 57股 | -47股-82.46% | 减仓 |
