| 安本标准投资Aberdeen Group plc |
| 0.02% | 0.01% | #12 | $1,267.1万 | 82.4万股 | $915.1万 | 824.4万股 | -742.0万股-90.00% | 减仓 |
| BVF INC/IL |
| 0.3% | 0.27% | #5 | $1,176.3万 | 76.5万股 | $849.5万 | 765.3万股 | -688.8万股-90.00% | 减仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #18 | $1,137.9万 | 74.0万股 | $419.6万 | 378.0万股 | -304.0万股-80.41% | 减仓 |
| Avidity Partners Management LP |
| 1.65% | 1.51% | #3 | $1,029.7万 | 67.0万股 | $743.6万 | 669.9万股 | -602.9万股-90.00% | 减仓 |
| BRAIDWELL LP |
| 0.37% | — | #4 | $991.4万 | 64.5万股 | $0 | 0股 | +64.5万股 | 新买入 |
| Laurion 资本管理Laurion Capital Management LP |
| 0.24% | 0.19% | #6 | $938.1万 | 61.0万股 | $430.9万 | 388.2万股 | -327.2万股-84.28% | 减仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #31 | $878.5万 | 57.2万股 | $570.4万 | 513.8万股 | -456.7万股-88.88% | 减仓 |
| Jones Hill Capital LP |
| 1.76% | — | #2 | $829.7万 | 54.0万股 | $0 | 0股 | +54.0万股 | 新买入 |
| Woodline合伙人Woodline Partners LP |
| 0.02% | <0.01% | #11 | $724.7万 | 47.2万股 | $107.4万 | 96.7万股 | -49.6万股-51.25% | 减仓 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.24% | 0.2% | #7 | $691.7万 | 45.0万股 | $499.5万 | 450.0万股 | -405.0万股-90.00% | 减仓 |
| Propel Bio Management, LLC |
| 2.61% | 1.65% | #1 | $499.6万 | 32.5万股 | $262.0万 | 234.5万股 | -202.0万股-86.14% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #29 | $399.1万 | 26.0万股 | $122.5万 | 110.4万股 | -84.4万股-76.47% | 减仓 |
| Nantahala 资本管理Nantahala Capital Management, LLC |
| 0.13% | 0.1% | #8 | $385.2万 | 25.1万股 | $278.2万 | 250.6万股 | -225.6万股-90.00% | 减仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #28 | $270.1万 | 17.6万股 | $58.0万 | 52.3万股 | -34.7万股-66.38% | 减仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #34 | $262.4万 | 17.1万股 | $169.4万 | 152.6万股 | -135.5万股-88.81% | 减仓 |
| 683 Capital Management, LLC |
| 0.11% | 0.14% | #9 | $226.3万 | 14.7万股 | $272.0万 | 245.0万股 | -230.3万股-93.99% | 减仓 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #23 | $215.0万 | 14.0万股 | $16.7万 | 15.1万股 | -1.1万股-7.10% | 减仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| <0.01% | <0.01% | #19 | $215.0万 | 14.0万股 | $155.2万 | 139.9万股 | -125.9万股-90.00% | 减仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #41 | $204.1万 | 13.3万股 | $107.0万 | 96.4万股 | -83.1万股-86.23% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #35 | $161.4万 | 10.5万股 | $89.5万 | 80.7万股 | -70.2万股-86.99% | 减仓 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #24 | $161.1万 | 10.5万股 | $105.8万 | 95.3万股 | -84.8万股-89.00% | 减仓 |
| 杰富瑞金融集团Jefferies Financial Group Inc. |
| 0.01% | — | #14 | $130.5万 | 8.5万股 | $0 | 0股 | +8.5万股 | 新买入 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #30 | $126.1万 | 8.2万股 | $82.2万 | 74.1万股 | -65.9万股-88.92% | 减仓 |
| Ikarian Capital, LLC |
| 0.11% | 0.06% | #10 | $103.7万 | 6.7万股 | $74.9万 | 67.5万股 | -60.7万股-90.00% | 减仓 |
| 正交资本Quadrature Capital Ltd |
| <0.01% | <0.01% | #17 | $58.1万 | 3.8万股 | $3.3万 | 3.0万股 | +8,159股+27.54% | 加仓 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #37 | $54.4万 | 3.5万股 | $29.0万 | 26.1万股 | -22.6万股-86.46% | 减仓 |
| 简化资产管理Simplify Asset Management Inc. |
| 0.01% | 0.01% | #15 | $47.2万 | 3.1万股 | $48.7万 | 43.9万股 | -40.8万股-93.00% | 减仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #40 | $47.2万 | 3.1万股 | $29.2万 | 26.3万股 | -23.3万股-88.33% | 减仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #44 | $36.5万 | 2.4万股 | $273.6万 | 310.3万股 | -307.9万股-99.23% | 减仓 |
| Brevan Howard资本管理Brevan Howard Capital Management LP |
| <0.01% | <0.01% | #21 | $35.6万 | 2.3万股 | $5.1万 | 4.6万股 | -2.3万股-49.43% | 减仓 |
| 法国巴黎银行金融市场BNP PARIBAS FINANCIAL MARKETS |
| <0.01% | <0.01% | #33 | $35.2万 | 2.3万股 | $13.5万 | 12.2万股 | -9.9万股-81.20% | 减仓 |
| Belvedere交易Belvedere Trading LLC |
| <0.01% | — | #27 | $31.4万 | 2.1万股 | $0 | 0股 | +2.1万股 | 新买入 |
| LPL金融LPL Financial LLC |
| <0.01% | <0.01% | #38 | $26.8万 | 1.7万股 | $18.8万 | 16.9万股 | -15.2万股-89.70% | 减仓 |
| MML投资者服务MML INVESTORS SERVICES, LLC |
| <0.01% | <0.01% | #26 | $22.5万 | 1.5万股 | $10.1万 | 9.1万股 | -7.6万股-83.82% | 减仓 |
| ALPS顾问ALPS ADVISORS INC |
| <0.01% | — | #25 | $21.2万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
| 布斯湾基金管理BOOTHBAY FUND MANAGEMENT, LLC |
| <0.01% | — | #20 | $20.1万 | 1.3万股 | $0 | 0股 | +1.3万股 | 新买入 |
| Point72资产管理Point72 Asset Management, L.P. |
| <0.01% | — | #32 | $16.6万 | 1.1万股 | $0 | 0股 | +1.1万股 | 新买入 |
| Strategies Wealth Advisors, LLC |
| 0.01% | 0.01% | #13 | $15.4万 | 1.0万股 | $11.1万 | 10.0万股 | -9.0万股-90.00% | 减仓 |
| China Universal Asset Management Co., Ltd. |
| 0.01% | — | #16 | $9.8万 | 6,400股 | $0 | 0股 | +6,400股 | 新买入 |
| 花旗集团CITIGROUP INC |
| <0.01% | — | #42 | $7.0万 | 4,569股 | $0 | 0股 | +4,569股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #43 | $4.9万 | 3,186股 | $3.5万 | 3.2万股 | -2.9万股-90.00% | 减仓 |
| OSAIC控股OSAIC HOLDINGS, INC. |
| <0.01% | <0.01% | #45 | $1.5万 | 1,000股 | $2.2万 | 2.0万股 | -1.9万股-95.00% | 减仓 |
| 加拿大皇家银行ROYAL BANK OF CANADA |
| <0.01% | <0.01% | #51 | $1.5万 | 1,000股 | $3,000 | 3,005股 | -2,005股-66.72% | 减仓 |
| Providence Capital Advisors, LLC |
| <0.01% | — | #22 | $1.0万 | 682股 | $0 | 0股 | +682股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #52 | $7,593 | 494股 | $2,695 | 2,428股 | -1,934股-79.65% | 减仓 |
| SBI Securities Co., Ltd. |
| <0.01% | <0.01% | #36 | $5,733 | 373股 | $4,179 | 3,765股 | -3,392股-90.09% | 减仓 |
| 西北互惠财富管理NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO |
| <0.01% | <0.01% | #53 | $2,306 | 150股 | $1,671 | 1,505股 | -1,355股-90.03% | 减仓 |
| Group One交易GROUP ONE TRADING LLC |
| <0.01% | <0.01% | #49 | $2,229 | 145股 | $1,889 | 1,702股 | -1,557股-91.48% | 减仓 |
| 富达投资FMR LLC |
| <0.01% | <0.01% | #55 | $1,968 | 128股 | $505 | 455股 | -327股-71.87% | 减仓 |
| 洛克菲勒资本管理Rockefeller Capital Management L.P. |
| <0.01% | <0.01% | #50 | $1,537 | 100股 | $1,110 | 1,000股 | -900股-90.00% | 减仓 |
