| 奥比梅德顾问ORBIMED ADVISORS LLC |
| 1.38% | 0.74% | #1 | $7,315.2万 | 1,372.5万股 | $3,731.0万 | 1,090.9万股 | +281.5万股+25.81% | 加仓 |
| 贝克兄弟顾问BAKER BROS. ADVISORS LP |
| 0.27% | 0.2% | #6 | $5,396.0万 | 1,012.4万股 | $3,462.3万 | 1,012.4万股 | 00.00% | 持仓不变 |
| RA资本管理RA CAPITAL MANAGEMENT, L.P. |
| 0.3% | — | #5 | $3,451.6万 | 647.6万股 | $0 | 0股 | +647.6万股 | 新买入 |
| Soleus 资本管理Soleus Capital Management, L.P. |
| 0.62% | — | #4 | $1,800.7万 | 337.8万股 | $0 | 0股 | +337.8万股 | 新买入 |
| Kynam Capital Management, LP |
| 0.71% | 0.34% | #2 | $1,287.2万 | 241.5万股 | $544.7万 | 159.3万股 | +82.3万股+51.65% | 加仓 |
| 先锋领航VANGUARD CAPITAL MANAGEMENT LLC |
| <0.01% | <0.01% | #33 | $1,071.0万 | 200.9万股 | $420.8万 | 123.0万股 | +77.9万股+63.32% | 加仓 |
| 贝莱德BlackRock, Inc. |
| <0.01% | <0.01% | #38 | $958.1万 | 179.8万股 | $110.1万 | 32.2万股 | +147.6万股+458.43% | 加仓 |
| SPHERA FUNDS MANAGEMENT LTD. |
| 0.71% | 0.3% | #3 | $543.6万 | 102.0万股 | $191.0万 | 55.8万股 | +46.1万股+82.65% | 加仓 |
| Two Sigma投资TWO SIGMA INVESTMENTS, LP |
| <0.01% | <0.01% | #16 | $529.5万 | 99.3万股 | $315.9万 | 92.4万股 | +7.0万股+7.55% | 加仓 |
| ADAR1 Capital Management, LLC |
| 0.22% | 0.03% | #7 | $480.2万 | 90.1万股 | $52.3万 | 15.3万股 | +74.8万股+489.50% | 加仓 |
| 千禧管理MILLENNIUM MANAGEMENT LLC |
| <0.01% | <0.01% | #19 | $450.4万 | 84.5万股 | $130.9万 | 38.3万股 | +46.2万股+120.78% | 加仓 |
| Geode资本管理GEODE CAPITAL MANAGEMENT, LLC |
| <0.01% | <0.01% | #31 | $448.8万 | 84.2万股 | $103.5万 | 30.2万股 | +53.9万股+178.34% | 加仓 |
| Adage资本合伙人ADAGE CAPITAL PARTNERS GP, L.L.C. |
| 0.01% | — | #12 | $408.3万 | 76.6万股 | $0 | 0股 | +76.6万股 | 新买入 |
| ACADIAN ASSET MANAGEMENT LLC |
| <0.01% | <0.01% | #15 | $325.9万 | 61.1万股 | $174.7万 | 51.2万股 | +10.0万股+19.52% | 加仓 |
| 摩根士丹利MORGAN STANLEY |
| <0.01% | <0.01% | #37 | $268.6万 | 50.4万股 | $40.9万 | 28.4万股 | +22.0万股+77.29% | 加仓 |
| 道富集团STATE STREET CORP |
| <0.01% | <0.01% | #46 | $228.5万 | 42.9万股 | $47.3万 | 13.8万股 | +29.1万股+210.20% | 加仓 |
| 瑞银集团UBS Group AG |
| <0.01% | <0.01% | #34 | $169.9万 | 31.9万股 | $22.1万 | 6.5万股 | +25.4万股+394.22% | 加仓 |
| 先锋信托VANGUARD FIDUCIARY TRUST CO |
| <0.01% | <0.01% | #28 | $151.8万 | 28.5万股 | $53.8万 | 15.7万股 | +12.8万股+81.02% | 加仓 |
| 文艺复兴科技RENAISSANCE TECHNOLOGIES LLC |
| <0.01% | <0.01% | #18 | $149.9万 | 28.1万股 | $94.1万 | 27.5万股 | +6,000股+2.18% | 加仓 |
| 北方信托NORTHERN TRUST CORP |
| <0.01% | <0.01% | #36 | $128.2万 | 24.1万股 | $17.1万 | 5.0万股 | +19.0万股+380.05% | 加仓 |
| 先锋领航组合管理VANGUARD PORTFOLIO MANAGEMENT LLC |
| <0.01% | — | #52 | $103.4万 | 19.4万股 | $0 | 0股 | +19.4万股 | 新买入 |
| 马歇尔·韦斯MARSHALL WACE, LLP |
| <0.01% | <0.01% | #21 | $101.6万 | 19.1万股 | $122.7万 | 35.9万股 | -16.8万股-46.87% | 减仓 |
| 萨斯奎汉纳国际集团SUSQUEHANNA INTERNATIONAL GROUP, LLP |
| <0.01% | <0.01% | #45 | $93.1万 | 17.5万股 | $98.8万 | 28.9万股 | -11.4万股-39.51% | 减仓 |
| Connor Clark & Lunn投资管理Connor, Clark & Lunn Investment Management Ltd. |
| <0.01% | <0.01% | #20 | $66.9万 | 12.6万股 | $37.3万 | 10.9万股 | +1.7万股+15.15% | 加仓 |
| 高盛集团GOLDMAN SACHS GROUP INC |
| <0.01% | <0.01% | #49 | $64.4万 | 12.1万股 | $80.9万 | 23.6万股 | -11.6万股-48.90% | 减仓 |
| 简街集团JANE STREET GROUP, LLC |
| <0.01% | <0.01% | #56 | $44.9万 | 8.4万股 | $66.0万 | 19.3万股 | -10.9万股-56.36% | 减仓 |
| Hillsdale Investment Management Inc. |
| 0.01% | — | #10 | $43.4万 | 8.1万股 | $0 | 0股 | +8.1万股 | 新买入 |
| 城堡顾问CITADEL ADVISORS LLC |
| <0.01% | <0.01% | #54 | $37.3万 | 7.0万股 | $42.5万 | 12.4万股 | -5.4万股-43.76% | 减仓 |
| 纽约梅隆银行Bank of New York Mellon Corp |
| <0.01% | — | #48 | $36.3万 | 6.8万股 | $0 | 0股 | +6.8万股 | 新买入 |
| 嘉信理财CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
| <0.01% | — | #50 | $36.0万 | 6.8万股 | $0 | 0股 | +6.8万股 | 新买入 |
| 桥道资本管理BRIDGEWAY CAPITAL MANAGEMENT, LLC |
| 0.01% | <0.01% | #11 | $34.4万 | 6.5万股 | $18.3万 | 5.4万股 | +1.1万股+20.56% | 加仓 |
| SquarepointSquarepoint Ops LLC |
| <0.01% | — | #26 | $31.7万 | 6.0万股 | $0 | 0股 | +6.0万股 | 新买入 |
| PanAgora资产管理PANAGORA ASSET MANAGEMENT INC |
| <0.01% | — | #22 | $25.4万 | 4.8万股 | $0 | 0股 | +4.8万股 | 新买入 |
| MarinerMariner, LLC |
| <0.01% | — | #30 | $24.1万 | 4.5万股 | $0 | 0股 | +4.5万股 | 新买入 |
| 纽文Nuveen, LLC |
| <0.01% | — | #51 | $19.7万 | 3.7万股 | $0 | 0股 | +3.7万股 | 新买入 |
| 维度基金顾问DIMENSIONAL FUND ADVISORS LP |
| <0.01% | <0.01% | #57 | $18.7万 | 3.5万股 | $12.0万 | 3.5万股 | 00.00% | 持仓不变 |
| 景顺Invesco Ltd. |
| <0.01% | — | #63 | $18.5万 | 3.5万股 | $0 | 0股 | +3.5万股 | 新买入 |
| Cerity合伙人Cerity Partners LLC |
| <0.01% | <0.01% | #35 | $17.5万 | 3.3万股 | $11.2万 | 3.3万股 | 00.00% | 持仓不变 |
| State of Wyoming |
| 0.02% | — | #9 | $17.5万 | 3.3万股 | $0 | 0股 | +3.3万股 | 新买入 |
| 格雷厄姆资本管理Graham Capital Management, L.P. |
| <0.01% | <0.01% | #17 | $15.9万 | 3.0万股 | $3.9万 | 1.1万股 | +1.8万股+162.45% | 加仓 |
| DEUTSCHE 银行 AG\DEUTSCHE BANK AG\ |
| <0.01% | — | #53 | $14.8万 | 2.8万股 | $0 | 0股 | +2.8万股 | 新买入 |
| 富国银行WELLS FARGO & COMPANY/MN |
| <0.01% | — | #62 | $13.5万 | 2.5万股 | $0 | 0股 | +2.5万股 | 新买入 |
| Simplex交易SIMPLEX TRADING, LLC |
| <0.01% | <0.01% | #44 | $13.2万 | 2.5万股 | $2,394 | 700股 | +2.4万股+3,442.86% | 加仓 |
| 美国银行BANK OF AMERICA CORP /DE/ |
| <0.01% | <0.01% | #71 | $12.7万 | 2.4万股 | $19.3万 | 5.7万股 | -3.3万股-57.76% | 减仓 |
| 普信集团PRICE T ROWE ASSOCIATES INC /MD/ |
| <0.01% | — | #67 | $12.1万 | 2.3万股 | $0 | 0股 | +2.3万股 | 新买入 |
| RhumbLine顾问RHUMBLINE ADVISERS |
| <0.01% | — | #42 | $11.8万 | 2.2万股 | $0 | 0股 | +2.2万股 | 新买入 |
| 先锋环球顾问Vanguard Global Advisers, LLC |
| <0.01% | <0.01% | #55 | $8.6万 | 1.6万股 | $1.6万 | 4,636股 | +1.2万股+249.65% | 加仓 |
| ExodusPoint资本ExodusPoint Capital Management, LP |
| <0.01% | — | #23 | $8.2万 | 1.5万股 | $0 | 0股 | +1.5万股 | 新买入 |
| 巴克莱BARCLAYS PLC |
| <0.01% | <0.01% | #64 | $7.7万 | 1.5万股 | $2.9万 | 8,600股 | +5,929股+68.94% | 加仓 |
| 纽约州共同退休基金NEW YORK STATE COMMON RETIREMENT FUND |
| <0.01% | — | #41 | $7.6万 | 1.4万股 | $0 | 0股 | +1.4万股 | 新买入 |
